Gene: ENSG00000131323 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000131323
Transcript Identifier
ENST00000392745
Gene Type
Coding gene
Location
14 : 102870202-102905784 : positive

Family Information

Homologous gene family
HOM03P005260
(17 genes in 6 species)
specific family

Descriptions

gene_descr
TNF receptor-associated factor 3

Identifiers

Type Value
pidENSP00000376500
HGNC12033
UniprotQ13114

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001817
ISS
IEA
Genome Projectregulation of cytokine production
GO:0002224
ISS
TAS, IEA
Genome Projecttoll-like receptor signaling pathway
GO:0002376
IEA
Genome Projectimmune system process
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0008063
IEA
Genome ProjectToll signaling pathway
GO:0016567
IEA
Genome Projectprotein ubiquitination
GO:0030162
IMP
Genome Projectregulation of proteolysis
GO:0032088
IMP
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032480
TAS
Genome Projectnegative regulation of type I interferon production
GO:0032648
ISS
IEA
Genome Projectregulation of interferon-beta production
GO:0033209
IMP
IEA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0050688
ISS
IEA
Genome Projectregulation of defense response to virus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IEA
Genome Projectubiquitin-protein transferase activity
GO:0004871
TAS
Genome Projectsignal transducer activity
GO:0005164
IPI
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031996
IPI
Genome Projectthioesterase binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005768
IEA
Genome Projectendosome
GO:0005829
TAS
Genome Projectcytosol
GO:0009898
ISS
IEA
Genome Projectcytoplasmic side of plasma membrane
GO:0035631
ISS
IEA
Genome ProjectCD40 receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001293Zinc finger, TRAF-type
IPR001841Zinc finger, RING-type
IPR002083MATH/TRAF domain
IPR008974TRAF-like
IPR012227TNF receptor-associated factor TRAF
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR013323SIAH-type domain
IPR017907Zinc finger, RING-type, conserved site
IPR027128TNF receptor-associated factor 3

No MapMan annotations defined for this gene.