Gene: ENSG00000130758 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000130758
Transcript Identifier
ENST00000253055
Gene Type
Coding gene
Location
19 : 40192032-40215292 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P011954
(7 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase kinase kinase 10

Identifiers

Type Value
pidENSP00000253055
HGNC6849
UniprotQ02779

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
IEA
Genome Projectactivation of MAPKK activity
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
TAS
Genome Projectapoptotic process
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007224
IMP
Genome Projectsmoothened signaling pathway
GO:0007254
TAS
Genome ProjectJNK cascade
GO:0007256
ISS
Genome Projectactivation of JNKK activity
GO:0007257
ISS
Genome Projectactivation of JUN kinase activity
GO:0008219
IEA
Genome Projectcell death
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
IDA
Genome Projectpeptidyl-threonine phosphorylation
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043433
IMP
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507
IMP
Genome Projectpositive regulation of JUN kinase activity
GO:0045892
IMP
ISS
Genome Projectnegative regulation of transcription, DNA-templated
GO:0046330
IMP
Genome Projectpositive regulation of JNK cascade
GO:0046777
ISS
Genome Projectprotein autophosphorylation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003714
ISS
IEA
Genome Projecttranscription corepressor activity
GO:0004672
TAS, IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004706
ISS
Genome ProjectJUN kinase kinase kinase activity
GO:0004709
IEA
Genome ProjectMAP kinase kinase kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0042803
ISS
Genome Projectprotein homodimerization activity
GO:0043425
IPI
Genome ProjectbHLH transcription factor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR015785Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR016231Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.