Gene: ENSG00000130203 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000130203
Transcript Identifier
ENST00000252486
Gene Type
Coding gene
Location
19 : 44906625-44909250 : positive

Family Information

Homologous gene family
HOM03P039089
(2 genes in 2 species)
specific family

Descriptions

gene_descr
apolipoprotein E

Identifiers

Type Value
pidENSP00000252486
HGNC613
UniprotP02649

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000302
NAS
Genome Projectresponse to reactive oxygen species
GO:0001523
TAS
Genome Projectretinoid metabolic process
GO:0001937
IDA
Genome Projectnegative regulation of endothelial cell proliferation
GO:0002021
IEA
Genome Projectresponse to dietary excess
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006641
IDA, IMP
Genome Projecttriglyceride metabolic process
GO:0006695
IBA
Genome Projectcholesterol biosynthetic process
GO:0006707
IBA
IEA
Genome Projectcholesterol catabolic process
GO:0006810
IEA
Genome Projecttransport
GO:0006869
IEA
Genome Projectlipid transport
GO:0006874
IEA
Genome Projectcellular calcium ion homeostasis
GO:0006898
IDA
TAS
Genome Projectreceptor-mediated endocytosis
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007010
TAS
Genome Projectcytoskeleton organization
GO:0007186
IDA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007263
IDA
Genome Projectnitric oxide mediated signal transduction
GO:0007271
TAS
Genome Projectsynaptic transmission, cholinergic
GO:0007603
TAS
Genome Projectphototransduction, visible light
GO:0008202
IEA
Genome Projectsteroid metabolic process
GO:0008203
IDA, IMP
IEA
Genome Projectcholesterol metabolic process
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010544
IDA
Genome Projectnegative regulation of platelet activation
GO:0010873
IDA
Genome Projectpositive regulation of cholesterol esterification
GO:0010875
IDA, IGI
Genome Projectpositive regulation of cholesterol efflux
GO:0015909
IDA
Genome Projectlong-chain fatty acid transport
GO:0017038
IDA
Genome Projectprotein import
GO:0019068
IMP
Genome Projectvirion assembly
GO:0019433
IBA
Genome Projecttriglyceride catabolic process
GO:0019934
IDA
Genome ProjectcGMP-mediated signaling
GO:0030195
IDA
Genome Projectnegative regulation of blood coagulation
GO:0030516
TAS
Genome Projectregulation of axon extension
GO:0030828
IDA
Genome Projectpositive regulation of cGMP biosynthetic process
GO:0031102
IBA
Genome Projectneuron projection regeneration
GO:0032489
IDA
Genome Projectregulation of Cdc42 protein signal transduction
GO:0032805
IDA
Genome Projectpositive regulation of low-density lipoprotein particle receptor catabolic process
GO:0033344
IDA
Genome Projectcholesterol efflux
GO:0033700
IDA
Genome Projectphospholipid efflux
GO:0034372
IDA, IGI
Genome Projectvery-low-density lipoprotein particle remodeling
GO:0034374
IEA
Genome Projectlow-density lipoprotein particle remodeling
GO:0034375
IGI
Genome Projecthigh-density lipoprotein particle remodeling
GO:0034380
IDA
Genome Projecthigh-density lipoprotein particle assembly
GO:0034382
IMP
Genome Projectchylomicron remnant clearance
GO:0034384
IDA
Genome Projecthigh-density lipoprotein particle clearance
GO:0034447
IDA, IMP
Genome Projectvery-low-density lipoprotein particle clearance
GO:0042157
TAS, IEA
Genome Projectlipoprotein metabolic process
GO:0042158
IEA
Genome Projectlipoprotein biosynthetic process
GO:0042159
IBA
IEA
Genome Projectlipoprotein catabolic process
GO:0042311
IEA
Genome Projectvasodilation
GO:0042632
IDA
Genome Projectcholesterol homeostasis
GO:0043407
IDA
Genome Projectnegative regulation of MAP kinase activity
GO:0043524
IBA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043537
IDA
Genome Projectnegative regulation of blood vessel endothelial cell migration
GO:0043691
IDA
Genome Projectreverse cholesterol transport
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0044794
IMP
Genome Projectpositive regulation by host of viral process
GO:0045541
IDA
Genome Projectnegative regulation of cholesterol biosynthetic process
GO:0046889
IDA
Genome Projectpositive regulation of lipid biosynthetic process
GO:0046907
TAS
Genome Projectintracellular transport
GO:0048168
TAS
Genome Projectregulation of neuronal synaptic plasticity
GO:0048844
IEA
Genome Projectartery morphogenesis
GO:0050728
IC, IEA
Genome Projectnegative regulation of inflammatory response
GO:0051000
IDA
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051044
IDA
Genome Projectpositive regulation of membrane protein ectodomain proteolysis
GO:0051055
IDA
Genome Projectnegative regulation of lipid biosynthetic process
GO:0051651
IEA
Genome Projectmaintenance of location in cell
GO:0055088
IEA
Genome Projectlipid homeostasis
GO:0055089
IDA
Genome Projectfatty acid homeostasis
GO:0060999
IDA
Genome Projectpositive regulation of dendritic spine development
GO:0061000
IDA
Genome Projectnegative regulation of dendritic spine development
GO:0072358
IEA
Genome Projectcardiovascular system development
GO:0090370
IDA
Genome Projectnegative regulation of cholesterol efflux
GO:0097113
IDA
Genome ProjectAMPA glutamate receptor clustering
GO:0097114
IDA
Genome ProjectNMDA glutamate receptor clustering
GO:1900221
IDA
Genome Projectregulation of beta-amyloid clearance
GO:1901214
IDA
Genome Projectregulation of neuron death
GO:1901215
IDA
Genome Projectnegative regulation of neuron death
GO:1901216
IDA
Genome Projectpositive regulation of neuron death
GO:1901627
IDA
Genome Projectnegative regulation of postsynaptic membrane organization
GO:1901628
IDA
Genome Projectpositive regulation of postsynaptic membrane organization
GO:1901630
IDA
Genome Projectnegative regulation of presynaptic membrane organization
GO:1901631
IDA
Genome Projectpositive regulation of presynaptic membrane organization
GO:1902004
IDA
Genome Projectpositive regulation of beta-amyloid formation
GO:1902430
IDA
Genome Projectnegative regulation of beta-amyloid formation
GO:1902947
IDA
Genome Projectregulation of tau-protein kinase activity
GO:1902951
IDA
Genome Projectnegative regulation of dendritic spine maintenance
GO:1902952
IDA
Genome Projectpositive regulation of dendritic spine maintenance
GO:1902995
IDA
Genome Projectpositive regulation of phospholipid efflux
GO:1902998
IDA
Genome Projectpositive regulation of neurofibrillary tangle assembly
GO:1902999
IDA
Genome Projectnegative regulation of phospholipid efflux
GO:1903001
IDA
Genome Projectnegative regulation of lipid transport across blood brain barrier
GO:1903002
IDA
Genome Projectpositive regulation of lipid transport across blood brain barrier

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001540
IDA
Genome Projectbeta-amyloid binding
GO:0005319
IDA
Genome Projectlipid transporter activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005543
IDA
Genome Projectphospholipid binding
GO:0008201
IDA
IEA
Genome Projectheparin binding
GO:0008289
IDA
IEA
Genome Projectlipid binding
GO:0015485
IBA
Genome Projectcholesterol binding
GO:0016209
IDA
Genome Projectantioxidant activity
GO:0017127
IBA
IEA
Genome Projectcholesterol transporter activity
GO:0042802
IDA
Genome Projectidentical protein binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0046911
IDA
Genome Projectmetal chelating activity
GO:0048156
IPI
Genome Projecttau protein binding
GO:0050750
IDA, IPI
Genome Projectlow-density lipoprotein particle receptor binding
GO:0060228
IDA
Genome Projectphosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070326
IDA, IPI
Genome Projectvery-low-density lipoprotein particle receptor binding
GO:0071813
IEA
Genome Projectlipoprotein particle binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005634
IDA
Genome Projectnucleus
GO:0005737
TAS, NAS
Genome Projectcytoplasm
GO:0005769
TAS
Genome Projectearly endosome
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005886
TAS
Genome Projectplasma membrane
GO:0016020
IDA
Genome Projectmembrane
GO:0030425
NAS
Genome Projectdendrite
GO:0031012
IDA
Genome Projectextracellular matrix
GO:0034361
IDA
IEA
Genome Projectvery-low-density lipoprotein particle
GO:0034362
IDA
Genome Projectlow-density lipoprotein particle
GO:0034363
IDA
Genome Projectintermediate-density lipoprotein particle
GO:0034364
IDA
IEA
Genome Projecthigh-density lipoprotein particle
GO:0042627
IDA
IEA
Genome Projectchylomicron
GO:0043025
NAS
Genome Projectneuronal cell body
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0071682
TAS
Genome Projectendocytic vesicle lumen
GO:0072562
IDA
Genome Projectblood microparticle
GO:1903561
IDA
Genome Projectextracellular vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000074Apolipoprotein A/E

No MapMan annotations defined for this gene.