Gene: ENSG00000128602 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000128602
Transcript Identifier
ENST00000249373
Gene Type
Coding gene
Location
7 : 129189152-129212451 : positive

Family Information

Homologous gene family
HOM03P002165
(40 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P039462
(3 genes in 3 species)
specific family

Descriptions

gene_descr
smoothened, frizzled class receptor

Identifiers

Type Value
pidENSP00000249373
HGNC11119
UniprotQ99835

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001503
IEA
Genome Projectossification
GO:0001570
IEA
Genome Projectvasculogenesis
GO:0001649
IEA
Genome Projectosteoblast differentiation
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001708
IEA
Genome Projectcell fate specification
GO:0001755
IEA
Genome Projectneural crest cell migration
GO:0001947
ISS
IEA
Genome Projectheart looping
GO:0002052
IEA
Genome Projectpositive regulation of neuroblast proliferation
GO:0002053
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0003007
IEA
Genome Projectheart morphogenesis
GO:0003140
ISS
IEA
Genome Projectdetermination of left/right asymmetry in lateral mesoderm
GO:0003323
IEA
Genome Projecttype B pancreatic cell development
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007166
IEA
Genome Projectcell surface receptor signaling pathway
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007224
IMP, IEP
IEA
Genome Projectsmoothened signaling pathway
GO:0007228
ISS
IEA
Genome Projectpositive regulation of hh target transcription factor activity
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007368
IEA
Genome Projectdetermination of left/right symmetry
GO:0007371
ISS
IEA
Genome Projectventral midline determination
GO:0007389
IEA
Genome Projectpattern specification process
GO:0007417
IEA
Genome Projectcentral nervous system development
GO:0007494
ISS
IEA
Genome Projectmidgut development
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0009953
IEA
Genome Projectdorsal/ventral pattern formation
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010628
ISS
IEA
Genome Projectpositive regulation of gene expression
GO:0010629
ISS
IEA
Genome Projectnegative regulation of gene expression
GO:0021696
IEA
Genome Projectcerebellar cortex morphogenesis
GO:0021794
IEA
Genome Projectthalamus development
GO:0021904
IEA
Genome Projectdorsal/ventral neural tube patterning
GO:0021910
IEA
Genome Projectsmoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938
IEA
Genome Projectsmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953
IEA
Genome Projectcentral nervous system neuron differentiation
GO:0021987
IEA
Genome Projectcerebral cortex development
GO:0030857
IEA
Genome Projectnegative regulation of epithelial cell differentiation
GO:0031069
IEA
Genome Projecthair follicle morphogenesis
GO:0034504
IEA
Genome Projectprotein localization to nucleus
GO:0035264
IEA
Genome Projectmulticellular organism growth
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0042307
IEA
Genome Projectpositive regulation of protein import into nucleus
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043392
ISS
IEA
Genome Projectnegative regulation of DNA binding
GO:0045880
IEA
Genome Projectpositive regulation of smoothened signaling pathway
GO:0045892
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046622
IEA
Genome Projectpositive regulation of organ growth
GO:0048143
IEA
Genome Projectastrocyte activation
GO:0048468
IEA
Genome Projectcell development
GO:0048565
IEA
Genome Projectdigestive tract development
GO:0048568
IEA
Genome Projectembryonic organ development
GO:0048589
IEA
Genome Projectdevelopmental growth
GO:0048741
IEA
Genome Projectskeletal muscle fiber development
GO:0048853
ISS
IEA
Genome Projectforebrain morphogenesis
GO:0048873
IEA
Genome Projecthomeostasis of number of cells within a tissue
GO:0050679
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050821
IEA
Genome Projectprotein stabilization
GO:0051451
IEA
Genome Projectmyoblast migration
GO:0051799
IEA
Genome Projectnegative regulation of hair follicle development
GO:0060248
IMP
Genome Projectdetection of cell density by contact stimulus involved in contact inhibition
GO:0060413
IEA
Genome Projectatrial septum morphogenesis
GO:0060644
IEA
Genome Projectmammary gland epithelial cell differentiation
GO:0060684
IEA
Genome Projectepithelial-mesenchymal cell signaling
GO:0061053
ISS
IEA
Genome Projectsomite development
GO:0061113
IEA
Genome Projectpancreas morphogenesis
GO:0070986
IEA
Genome Projectleft/right axis specification
GO:0071397
ISS
IEA
Genome Projectcellular response to cholesterol
GO:0072001
IEP
Genome Projectrenal system development
GO:0072285
ISS
IEA
Genome Projectmesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190
ISS
IEA
Genome Projectpositive regulation of branching involved in ureteric bud morphogenesis
GO:2000036
IEA
Genome Projectregulation of stem cell population maintenance
GO:2000826
ISS
IEA
Genome Projectregulation of heart morphogenesis
GO:0035567
IBA
Genome Projectnon-canonical Wnt signaling pathway
GO:0060070
IBA
Genome Projectcanonical Wnt signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0004930
IBA
IEA
Genome ProjectG-protein coupled receptor activity
GO:0005113
IPI
Genome Projectpatched binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008144
IDA
Genome Projectdrug binding
GO:0017147
IBA
Genome ProjectWnt-protein binding
GO:0042813
IBA
Genome ProjectWnt-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005929
IEA
Genome Projectcilium
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IBA
IEA
Genome Projectintegral component of membrane
GO:0030666
TAS
Genome Projectendocytic vesicle membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0060170
TAS, IEA
Genome Projectciliary membrane
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0072372
TAS, IEA
Genome Projectprimary cilium
GO:0097542
TAS
Genome Projectciliary tip
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005901
IDA
Genome Projectcaveola

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000539Frizzled protein
IPR015526Frizzled/secreted frizzled-related protein
IPR017981GPCR, family 2-like
IPR020067Frizzled domain
IPR026544Smoothened

No MapMan annotations defined for this gene.