Gene: ENSG00000128342 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000128342
Transcript Identifier
ENST00000249075
Gene Type
Coding gene
Location
22 : 30243651-30246695 : negative

Family Information

Homologous gene family
HOM03P038977
(2 genes in 2 species)
specific family

Descriptions

gene_descr
leukemia inhibitory factor

Identifiers

Type Value
pidENSP00000249075
HGNC6596
UniprotP15018

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0006955
IEA
Genome Projectimmune response
GO:0007275
TAS
Genome Projectmulticellular organismal development
GO:0007566
IEA
Genome Projectembryo implantation
GO:0008284
IDA
TAS
Genome Projectpositive regulation of cell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010976
IEA
Genome Projectpositive regulation of neuron projection development
GO:0016525
IEA
Genome Projectnegative regulation of angiogenesis
GO:0019827
IEA
Genome Projectstem cell population maintenance
GO:0030324
IEA
Genome Projectlung development
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033141
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042503
IEA
Genome Projecttyrosine phosphorylation of Stat3 protein
GO:0042511
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0045595
IEA
Genome Projectregulation of cell differentiation
GO:0045651
IDA
Genome Projectpositive regulation of macrophage differentiation
GO:0045835
IEA
Genome Projectnegative regulation of meiotic nuclear division
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046697
IEA
Genome Projectdecidualization
GO:0046888
IDA
Genome Projectnegative regulation of hormone secretion
GO:0048286
IEA
Genome Projectlung alveolus development
GO:0048644
IEA
Genome Projectmuscle organ morphogenesis
GO:0048666
IEA
Genome Projectneuron development
GO:0048708
IEA
Genome Projectastrocyte differentiation
GO:0048711
IEA
Genome Projectpositive regulation of astrocyte differentiation
GO:0048861
IDA
Genome Projectleukemia inhibitory factor signaling pathway
GO:0048863
IEA
Genome Projectstem cell differentiation
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051461
IEA
Genome Projectpositive regulation of corticotropin secretion
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0060135
IEA
Genome Projectmaternal process involved in female pregnancy
GO:0060290
IEA
Genome Projecttransdifferentiation
GO:0060426
IEA
Genome Projectlung vasculature development
GO:0060463
IEA
Genome Projectlung lobe morphogenesis
GO:0060707
IEA
Genome Projecttrophoblast giant cell differentiation
GO:0060708
IEA
Genome Projectspongiotrophoblast differentiation
GO:0070373
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0072108
IDA
Genome Projectpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072307
IDA
Genome Projectregulation of metanephric nephron tubule epithelial cell differentiation
GO:1900182
IDA
Genome Projectpositive regulation of protein localization to nucleus
GO:1901676
IDA
Genome Projectpositive regulation of histone H3-K27 acetylation
GO:1903025
IEA
Genome Projectregulation of RNA polymerase II regulatory region sequence-specific DNA binding

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001135
IDA
Genome Projecttranscription factor activity, RNA polymerase II transcription factor recruiting
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005125
IDA
IEA
Genome Projectcytokine activity
GO:0005146
IDA, IPI
IEA
Genome Projectleukemia inhibitory factor receptor binding
GO:0008083
IDA
IEA
Genome Projectgrowth factor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IC, IEA
Genome Projectextracellular space
GO:0005737
IDA
Genome Projectcytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001581Leukemia inhibitory factor /oncostatin
IPR003624Leukemia inhibitory factor
IPR009079Four-helical cytokine-like, core
IPR012351Four-helical cytokine, core
IPR019827Leukemia inhibitory factor /oncostatin, conserved site

No MapMan annotations defined for this gene.