Gene: ENSG00000128052 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000128052
Transcript Identifier
ENST00000263923
Gene Type
Coding gene
Location
4 : 55079941-55125293 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P018477
(5 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
kinase insert domain receptor

Identifiers

Type Value
pidENSP00000263923
HGNC6307
UniprotP35968
UniprotA0A024RD88

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001541
IEA
Genome Projectovarian follicle development
GO:0001570
ISS
IEA
Genome Projectvasculogenesis
GO:0001945
IEA
Genome Projectlymph vessel development
GO:0002053
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IEA
Genome Projectcell migration
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030097
IEA
Genome Projecthemopoiesis
GO:0030324
IEA
Genome Projectlung development
GO:0038084
IDA
IEA
Genome Projectvascular endothelial growth factor signaling pathway
GO:0043129
IEA
Genome Projectsurfactant homeostasis
GO:0045165
IEA
Genome Projectcell fate commitment
GO:0045446
IEA
Genome Projectendothelial cell differentiation
GO:0045601
IEA
Genome Projectregulation of endothelial cell differentiation
GO:0048010
IDA, IMP
TAS, IEA
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048286
IEA
Genome Projectlung alveolus development
GO:0048469
IEA
Genome Projectcell maturation
GO:0048754
IEA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0050679
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0055074
IEA
Genome Projectcalcium ion homeostasis
GO:1901532
IEA
Genome Projectregulation of hematopoietic progenitor cell differentiation
GO:0001525
TAS, IEA
Genome Projectangiogenesis
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
IMP
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002042
ISS
Genome Projectcell migration involved in sprouting angiogenesis
GO:0003158
ISS
Genome Projectendothelium development
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008284
IDA, IMP
Genome Projectpositive regulation of cell proliferation
GO:0008360
IDA
Genome Projectregulation of cell shape
GO:0010595
IMP
Genome Projectpositive regulation of endothelial cell migration
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032
IEA
Genome Projectviral process
GO:0023014
TAS
Genome Projectsignal transduction by protein phosphorylation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030335
IDA, IMP
Genome Projectpositive regulation of cell migration
GO:0035162
ISS
Genome Projectembryonic hemopoiesis
GO:0035584
IMP
Genome Projectcalcium-mediated signaling using intracellular calcium source
GO:0035924
IDA, IMP
Genome Projectcellular response to vascular endothelial growth factor stimulus
GO:0038083
ISS
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0050927
IDA
Genome Projectpositive regulation of positive chemotaxis
GO:0051770
IDA, IMP
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0051894
IDA
Genome Projectpositive regulation of focal adhesion assembly
GO:0070374
IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:2000352
IDA
Genome Projectnegative regulation of endothelial cell apoptotic process
GO:2001214
ISS
Genome Projectpositive regulation of vasculogenesis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
EXP, IDA
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005021
IDA
IEA
Genome Projectvascular endothelial growth factor-activated receptor activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019838
IPI
IEA
Genome Projectgrowth factor binding
GO:0004716
TAS
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0005178
IPI
Genome Projectintegrin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0038085
IPI
Genome Projectvascular endothelial growth factor binding
GO:0051879
TAS
Genome ProjectHsp90 protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0071944
IEA
Genome Projectcell periphery
GO:0005576
IEA
Genome Projectextracellular region
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005768
IDA
IEA
Genome Projectendosome
GO:0005769
ISS
IEA
Genome Projectearly endosome
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005886
IDA
ISS
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
TAS
Genome Projectintegral component of plasma membrane
GO:0016023
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0030054
ISS
IEA
Genome Projectcell junction
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0045121
IDA
Genome Projectmembrane raft
GO:0097443
ISS
Genome Projectsorting endosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001824Tyrosine-protein kinase, receptor class III, conserved site
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR009136Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR011009Protein kinase-like domain
IPR013098Immunoglobulin I-set
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.