Gene: ENSG00000127831 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000127831
Transcript Identifier
ENST00000248444
Gene Type
Coding gene
Location
2 : 218423779-218449336 : positive

Family Information

Homologous gene family
HOM03P000775
(73 genes in 23 species)
specific family
Orthologous gene family
ORTHO03P000870
(42 genes in 21 species)
specific family

Descriptions

gene_descr
villin 1

Identifiers

Type Value
pidENSP00000248444
HGNC12690
UniprotP09327

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001951
IEA
Genome Projectintestinal D-glucose absorption
GO:0006461
TAS
Genome Projectprotein complex assembly
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007010
IEA
Genome Projectcytoskeleton organization
GO:0007173
IDA
Genome Projectepidermal growth factor receptor signaling pathway
GO:0008360
IDA
Genome Projectregulation of cell shape
GO:0009617
IDA
Genome Projectresponse to bacterium
GO:0010634
IDA, IMP, IGI
Genome Projectpositive regulation of epithelial cell migration
GO:0030041
IDA
Genome Projectactin filament polymerization
GO:0030042
IDA
Genome Projectactin filament depolymerization
GO:0030335
IDA
Genome Projectpositive regulation of cell migration
GO:0030836
IMP
Genome Projectpositive regulation of actin filament depolymerization
GO:0030855
IEP
Genome Projectepithelial cell differentiation
GO:0032233
IDA
Genome Projectpositive regulation of actin filament bundle assembly
GO:0032532
IEA
Genome Projectregulation of microvillus length
GO:0035729
IEA
Genome Projectcellular response to hepatocyte growth factor stimulus
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0043154
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045010
IEA
Genome Projectactin nucleation
GO:0051014
IDA
TAS, IEA
Genome Projectactin filament severing
GO:0051016
IMP
Genome Projectbarbed-end actin filament capping
GO:0051125
IDA
Genome Projectregulation of actin nucleation
GO:0051693
IDA
IEA
Genome Projectactin filament capping
GO:0060327
IDA
Genome Projectcytoplasmic actin-based contraction involved in cell motility
GO:0061041
ISS
IEA
Genome Projectregulation of wound healing
GO:0071364
IDA
Genome Projectcellular response to epidermal growth factor stimulus
GO:0090004
IEA
Genome Projectpositive regulation of establishment of protein localization to plasma membrane
GO:1902896
IEA
Genome Projectterminal web assembly
GO:2000392
ISS
IEA
Genome Projectregulation of lamellipodium morphogenesis
GO:2000394
IMP, IGI
Genome Projectpositive regulation of lamellipodium morphogenesis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003779
IEA
Genome Projectactin binding
GO:0005509
IDA, IMP
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005546
IDA
IEA
Genome Projectphosphatidylinositol-4,5-bisphosphate binding
GO:0035727
IDA
Genome Projectlysophosphatidic acid binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0043027
ISS
IEA
Genome Projectcysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0051015
IDA
IEA
Genome Projectactin filament binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001726
IDA
IEA
Genome Projectruffle
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005902
IDA
IEA
Genome Projectmicrovillus
GO:0005903
ISS
Genome Projectbrush border
GO:0030027
IDA
IEA
Genome Projectlamellipodium
GO:0030175
IDA
IEA
Genome Projectfilopodium
GO:0032432
IDA
Genome Projectactin filament bundle
GO:0032433
ISS
IEA
Genome Projectfilopodium tip
GO:0042995
IEA
Genome Projectcell projection
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003128Villin headpiece
IPR007122Villin/Gelsolin
IPR007123Gelsolin-like domain
IPR029006ADF-H/Gelsolin-like domain
IPR030007Villin

No MapMan annotations defined for this gene.