Gene: ENSG00000127191 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000127191
Transcript Identifier
ENST00000247668
Gene Type
Coding gene
Location
9 : 136898741-136925901 : positive

Family Information

Homologous gene family
HOM03P005260
(17 genes in 6 species)
specific family
Orthologous gene family
ORTHO03P073636
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
TNF receptor-associated factor 2

Identifiers

Type Value
pidENSP00000247668
HGNC12032
UniprotQ12933
UniprotA0A024R8H5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006461
TAS, IEA
Genome Projectprotein complex assembly
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007250
IMP
IEA
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0030163
IEA
Genome Projectprotein catabolic process
GO:0033209
IDA
TAS, IEA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034351
IEA
Genome Projectnegative regulation of glial cell apoptotic process
GO:0042981
IDA
IEA
Genome Projectregulation of apoptotic process
GO:0043123
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043623
ISS
IEA
Genome Projectcellular protein complex assembly
GO:0046328
IEA
Genome Projectregulation of JNK cascade
GO:0051023
IEA
Genome Projectregulation of immunoglobulin secretion
GO:0051092
IDA, IMP
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0051865
IDA
TAS, IEA
Genome Projectprotein autoubiquitination
GO:0071732
IEA
Genome Projectcellular response to nitric oxide
GO:0097300
TAS, IEA
Genome Projectprogrammed necrotic cell death
GO:1903265
IEA
Genome Projectpositive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903721
IEA
Genome Projectpositive regulation of I-kappaB phosphorylation
GO:0002726
IMP
Genome Projectpositive regulation of T cell cytokine production
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0010939
TAS
Genome Projectregulation of necrotic cell death
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0016567
IEA
Genome Projectprotein ubiquitination
GO:0032743
IMP
Genome Projectpositive regulation of interleukin-2 production
GO:0034976
NAS
Genome Projectresponse to endoplasmic reticulum stress
GO:0043154
TAS
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043507
IDA
Genome Projectpositive regulation of JUN kinase activity
GO:0045087
TAS
Genome Projectinnate immune response
GO:0050870
IC
Genome Projectpositive regulation of T cell activation
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0070059
TAS
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070207
IPI
Genome Projectprotein homotrimerization
GO:0070266
TAS
Genome Projectnecroptotic process
GO:0070534
IDA
Genome Projectprotein K63-linked ubiquitination
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0090073
IMP
Genome Projectpositive regulation of protein homodimerization activity
GO:0097191
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1901215
TAS
Genome Projectnegative regulation of neuron death
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IDA
IEA
Genome Projectubiquitin-protein transferase activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005174
ISS
IEA
Genome ProjectCD40 receptor binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0019901
IPI
IEA
Genome Projectprotein kinase binding
GO:0031435
IEA
Genome Projectmitogen-activated protein kinase kinase kinase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0004871
NAS
Genome Projectsignal transducer activity
GO:0005164
IPI
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031996
IPI
Genome Projectthioesterase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0046625
IDA
Genome Projectsphingolipid binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005938
IEA
Genome Projectcell cortex
GO:0009898
ISS
IEA
Genome Projectcytoplasmic side of plasma membrane
GO:0012506
IEA
Genome Projectvesicle membrane
GO:0035631
ISS
IEA
Genome ProjectCD40 receptor complex
GO:0043234
IEA
Genome Projectprotein complex
GO:0045121
IEA
Genome Projectmembrane raft
GO:1990597
IEA
Genome ProjectAIP1-IRE1 complex
GO:0000151
IPI
Genome Projectubiquitin ligase complex
GO:0097057
IDA
Genome ProjectTRAF2-GSTP1 complex
GO:1990604
IDA
Genome ProjectIRE1-TRAF2-ASK1 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001293Zinc finger, TRAF-type
IPR001841Zinc finger, RING-type
IPR002083MATH/TRAF domain
IPR008974TRAF-like
IPR012227TNF receptor-associated factor TRAF
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR017907Zinc finger, RING-type, conserved site
IPR018957Zinc finger, C3HC4 RING-type
IPR027133TNF receptor-associated factor 2
IPR032070TNF receptor-associated factor, BIRC3 binding domain

No MapMan annotations defined for this gene.