Gene: ENSG00000126581 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000126581
Transcript Identifier
ENST00000590099
Gene Type
Coding gene
Location
17 : 42810760-42823877 : negative

Family Information

Homologous gene family
HOM03P001927
(43 genes in 32 species)
specific family

Descriptions

gene_descr
beclin 1, autophagy related

Identifiers

Type Value
pidENSP00000465364
HGNC1034
UniprotQ14457
UniprotA0A024R1X5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006914
IMP
IEA
Genome Projectautophagy
GO:0007040
IEA
Genome Projectlysosome organization
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0016236
ISS
IEA
Genome Projectmacroautophagy
GO:0016239
IEA
Genome Projectpositive regulation of macroautophagy
GO:0042149
ISS
IEA
Genome Projectcellular response to glucose starvation
GO:0043066
TAS, IEA
Genome Projectnegative regulation of apoptotic process
GO:0043652
IEA
Genome Projectengulfment of apoptotic cell
GO:0048666
IEA
Genome Projectneuron development
GO:0050435
IEA
Genome Projectbeta-amyloid metabolic process
GO:0050790
IEA
Genome Projectregulation of catalytic activity
GO:0051707
IEA
Genome Projectresponse to other organism
GO:2000378
IEA
Genome Projectnegative regulation of reactive oxygen species metabolic process
GO:0000045
ISS, IBA
Genome Projectautophagosome assembly
GO:0000910
IMP
Genome Projectcytokinesis
GO:0006897
IEA
Genome Projectendocytosis
GO:0006968
TAS
Genome Projectcellular defense response
GO:0006995
IBA
Genome Projectcellular response to nitrogen starvation
GO:0007049
IEA
Genome Projectcell cycle
GO:0007080
IMP
Genome Projectmitotic metaphase plate congression
GO:0010508
IMP
Genome Projectpositive regulation of autophagy
GO:0016032
IEA
Genome Projectviral process
GO:0032258
IBA
Genome ProjectCVT pathway
GO:0032465
IMP
Genome Projectregulation of cytokinesis
GO:0032801
IMP
Genome Projectreceptor catabolic process
GO:0044804
IBA
Genome Projectnucleophagy
GO:0045324
IBA
Genome Projectlate endosome to vacuole transport
GO:0051301
IEA
Genome Projectcell division
GO:0051607
IEA
Genome Projectdefense response to virus
GO:0098779
IMP
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1902425
IMP
Genome Projectpositive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903599
IMP
Genome Projectpositive regulation of mitophagy

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0043548
IPI
Genome Projectphosphatidylinositol 3-kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005802
IEA
Genome Projecttrans-Golgi network
GO:0016023
IBA
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0035032
ISS
IEA
Genome Projectphosphatidylinositol 3-kinase complex, class III
GO:0043234
IEA
Genome Projectprotein complex
GO:0045335
IEA
Genome Projectphagocytic vesicle
GO:0000407
IBA
Genome Projectpre-autophagosomal structure
GO:0005739
IMP
IEA
Genome Projectmitochondrion
GO:0005768
IDA
IEA
Genome Projectendosome
GO:0005776
IEA
Genome Projectautophagosome
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0010008
IEA
Genome Projectendosome membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0019898
IDA
Genome Projectextrinsic component of membrane
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0031966
IEA
Genome Projectmitochondrial membrane
GO:0034271
IBA
Genome Projectphosphatidylinositol 3-kinase complex, class III, type I
GO:0034272
IBA
Genome Projectphosphatidylinositol 3-kinase complex, class III, type II

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR007243Atg6/Beclin
IPR029318Beclin-1, BH3 domain

No MapMan annotations defined for this gene.