Gene: ENSG00000125965 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125965
Transcript Identifier
ENST00000374372
Gene Type
Coding gene
Location
20 : 35433909-35437928 : negative

Family Information

Homologous gene family
HOM03P001000
(62 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P063370
(2 genes in 2 species)
specific family

Descriptions

gene_descr
growth differentiation factor 5

Identifiers

Type Value
pidENSP00000363492
HGNC4220
UniprotP43026
UniprotF1T0J1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002062
IEA
Genome Projectchondrocyte differentiation
GO:0007178
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030326
IEA
Genome Projectembryonic limb morphogenesis
GO:0032332
IDA
IEA
Genome Projectpositive regulation of chondrocyte differentiation
GO:0035136
IEA
Genome Projectforelimb morphogenesis
GO:0035137
IEA
Genome Projecthindlimb morphogenesis
GO:0040007
IEA
Genome Projectgrowth
GO:0040014
IEA
Genome Projectregulation of multicellular organism growth
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045666
IEA
Genome Projectpositive regulation of neuron differentiation
GO:2001054
IEA
Genome Projectnegative regulation of mesenchymal cell apoptotic process
GO:0007179
TAS
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007184
IDA
Genome ProjectSMAD protein import into nucleus
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0010862
IBA
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030509
IBA
Genome ProjectBMP signaling pathway
GO:0030513
IDA
Genome Projectpositive regulation of BMP signaling pathway
GO:0032331
IDA
Genome Projectnegative regulation of chondrocyte differentiation
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0043408
IBA
Genome Projectregulation of MAPK cascade
GO:0048468
IBA
Genome Projectcell development
GO:0050680
IDA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0051216
IEA
Genome Projectcartilage development
GO:0060395
IDA
Genome ProjectSMAD protein signal transduction
GO:0060591
IDA
Genome Projectchondroblast differentiation
GO:0098779
IGI
Genome Projectmitophagy in response to mitochondrial depolarization

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
IEA
Genome Projectreceptor binding
GO:0008083
TAS, IEA
Genome Projectgrowth factor activity
GO:0005125
IBA
IEA
Genome Projectcytokine activity
GO:0005160
IBA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0036122
IPI
Genome ProjectBMP binding
GO:0042802
IPI
Genome Projectidentical protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IBA
IEA
Genome Projectextracellular space
GO:0005622
IDA
Genome Projectintracellular
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR015615Transforming growth factor-beta-related
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.