Gene: ENSG00000125845 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125845
Transcript Identifier
ENST00000378827
Gene Type
Coding gene
Location
20 : 6770127-6779089 : positive

Family Information

Homologous gene family
HOM03P001000
(62 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P038850
(3 genes in 3 species)
specific family

Descriptions

gene_descr
bone morphogenetic protein 2

Identifiers

Type Value
pidENSP00000368104
HGNC1069
UniprotP12643
UniprotC8C060

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001658
ISS
IEA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001666
ISS
IEA
Genome Projectresponse to hypoxia
GO:0001701
ISS
IEA
Genome Projectin utero embryonic development
GO:0003181
ISS
IEA
Genome Projectatrioventricular valve morphogenesis
GO:0003203
ISS
IEA
Genome Projectendocardial cushion morphogenesis
GO:0006029
IEA
Genome Projectproteoglycan metabolic process
GO:0006954
ISS
IEA
Genome Projectinflammatory response
GO:0007219
ISS
IEA
Genome ProjectNotch signaling pathway
GO:0007507
ISS
IEA
Genome Projectheart development
GO:0009887
ISS
IEA
Genome Projectorgan morphogenesis
GO:0010629
IEA
Genome Projectnegative regulation of gene expression
GO:0021978
ISS
IEA
Genome Projecttelencephalon regionalization
GO:0030177
ISS
IEA
Genome Projectpositive regulation of Wnt signaling pathway
GO:0030282
ISS
IEA
Genome Projectbone mineralization
GO:0030335
ISS
IEA
Genome Projectpositive regulation of cell migration
GO:0031648
IEA
Genome Projectprotein destabilization
GO:0033690
ISS
IEA
Genome Projectpositive regulation of osteoblast proliferation
GO:0035054
ISS
IEA
Genome Projectembryonic heart tube anterior/posterior pattern specification
GO:0040007
IEA
Genome Projectgrowth
GO:0042475
ISS
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0042482
ISS
IEA
Genome Projectpositive regulation of odontogenesis
GO:0042487
IEA
Genome Projectregulation of odontogenesis of dentin-containing tooth
GO:0045165
ISS
IEA
Genome Projectcell fate commitment
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0045600
ISS
IEA
Genome Projectpositive regulation of fat cell differentiation
GO:0045666
ISS
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0045778
IDA
IEA
Genome Projectpositive regulation of ossification
GO:0048711
ISS
IEA
Genome Projectpositive regulation of astrocyte differentiation
GO:0048839
ISS
IEA
Genome Projectinner ear development
GO:0055008
ISS
IEA
Genome Projectcardiac muscle tissue morphogenesis
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0060039
ISS
IEA
Genome Projectpericardium development
GO:0060128
ISS
IEA
Genome Projectcorticotropin hormone secreting cell differentiation
GO:0060129
ISS
IEA
Genome Projectthyroid-stimulating hormone-secreting cell differentiation
GO:0060804
ISS
IEA
Genome Projectpositive regulation of Wnt signaling pathway by BMP signaling pathway
GO:0061036
IDA
IEA
Genome Projectpositive regulation of cartilage development
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0072138
ISS
IEA
Genome Projectmesenchymal cell proliferation involved in ureteric bud development
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000187
IDA
Genome Projectactivation of MAPK activity
GO:0001501
TAS
Genome Projectskeletal system development
GO:0001503
IEA
Genome Projectossification
GO:0001649
IDA
Genome Projectosteoblast differentiation
GO:0001837
IDA
Genome Projectepithelial to mesenchymal transition
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
IDA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002062
IDA
Genome Projectchondrocyte differentiation
GO:0003130
IDA
Genome ProjectBMP signaling pathway involved in heart induction
GO:0003308
IDA
Genome Projectnegative regulation of Wnt signaling pathway involved in heart development
GO:0006355
IDA
Genome Projectregulation of transcription, DNA-templated
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0009790
ISS
Genome Projectembryo development
GO:0010628
IDA
Genome Projectpositive regulation of gene expression
GO:0010718
IDA
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0010862
IDA, IMP
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894
IDA
Genome Projectnegative regulation of steroid biosynthetic process
GO:0010922
IDA
Genome Projectpositive regulation of phosphatase activity
GO:0021537
IDA
Genome Projecttelencephalon development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030501
IDA
Genome Projectpositive regulation of bone mineralization
GO:0030509
IDA, IMP, IEP
TAS
Genome ProjectBMP signaling pathway
GO:0032092
IDA
Genome Projectpositive regulation of protein binding
GO:0032348
IDA
Genome Projectnegative regulation of aldosterone biosynthetic process
GO:0035051
IDA, IMP
Genome Projectcardiocyte differentiation
GO:0035630
IDA
Genome Projectbone mineralization involved in bone maturation
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0043569
IDA
Genome Projectnegative regulation of insulin-like growth factor receptor signaling pathway
GO:0045669
IDA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045786
IDA
Genome Projectnegative regulation of cell cycle
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048468
IBA
Genome Projectcell development
GO:0048762
IDA
Genome Projectmesenchymal cell differentiation
GO:0051042
IDA
Genome Projectnegative regulation of calcium-independent cell-cell adhesion
GO:0051216
IEA
Genome Projectcartilage development
GO:0055007
IMP
Genome Projectcardiac muscle cell differentiation
GO:0060317
IDA
Genome Projectcardiac epithelial to mesenchymal transition
GO:0060389
IDA
Genome Projectpathway-restricted SMAD protein phosphorylation
GO:0060395
IDA
Genome ProjectSMAD protein signal transduction
GO:0060485
IMP
Genome Projectmesenchyme development
GO:0070374
IDA, IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071773
IDA, IMP
Genome Projectcellular response to BMP stimulus
GO:0090090
IEP
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:1900745
IDA
Genome Projectpositive regulation of p38MAPK cascade
GO:1901522
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065
IDA
Genome Projectnegative regulation of cortisol biosynthetic process
GO:2000726
IDA
Genome Projectnegative regulation of cardiac muscle cell differentiation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004745
ISS
IEA
Genome Projectretinol dehydrogenase activity
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0005102
TAS
Genome Projectreceptor binding
GO:0005125
IBA
IEA
Genome Projectcytokine activity
GO:0005160
IBA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019211
IDA
Genome Projectphosphatase activator activity
GO:0039706
IPI
Genome Projectco-receptor binding
GO:0046332
IDA
Genome ProjectSMAD binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0070700
IDA
Genome ProjectBMP receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
IBA
IEA
Genome Projectextracellular space
GO:0009986
IDA
Genome Projectcell surface
GO:0070724
IDA
Genome ProjectBMP receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR002405Inhibin, alpha subunit
IPR015615Transforming growth factor-beta-related
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.