Gene: ENSG00000125818 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125818
Transcript Identifier
ENST00000335877
Gene Type
Coding gene
Location
20 : 1118774-1165080 : positive

Family Information

Homologous gene family
HOM03P016465
(5 genes in 4 species)
specific family

Descriptions

gene_descr
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Identifiers

Type Value
pidENSP00000338039
HGNC9571
UniprotQ92530

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000082
TAS
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000209
TAS
Genome Projectprotein polyubiquitination
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002474
TAS
Genome Projectantigen processing and presentation of peptide antigen via MHC class I
GO:0002479
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006511
IDA
Genome Projectubiquitin-dependent protein catabolic process
GO:0006521
TAS
Genome Projectregulation of cellular amino acid metabolic process
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006977
TAS
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467
TAS
Genome Projectgene expression
GO:0010951
NAS
Genome Projectnegative regulation of endopeptidase activity
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0016032
TAS
Genome Projectviral process
GO:0031145
TAS
Genome Projectanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641
TAS
Genome Projectcellular nitrogen compound metabolic process
GO:0042590
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0051436
TAS
Genome Projectnegative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437
TAS
Genome Projectpositive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0051439
TAS
Genome Projectregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0090090
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090263
TAS
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1901799
IDA
Genome Projectnegative regulation of proteasomal protein catabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004866
NAS
Genome Projectendopeptidase inhibitor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0070628
IDA
Genome Projectproteasome binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000502
IEA
Genome Projectproteasome complex
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005839
NAS
Genome Projectproteasome core complex
GO:0016020
IDA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR013886PI31 proteasome regulator, C-terminal
IPR021625PI31 proteasome regulator, N-terminal

No MapMan annotations defined for this gene.