Gene: ENSG00000125538 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125538
Transcript Identifier
ENST00000263341
Gene Type
Coding gene
Location
2 : 112830361-112836229 : negative

Family Information

Homologous gene family
HOM03P038064
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 1, beta

Identifiers

Type Value
pidENSP00000263341
HGNC5992
UniprotP01584

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000165
IMP
Genome ProjectMAPK cascade
GO:0000187
IDA
Genome Projectactivation of MAPK activity
GO:0001660
IBA
IEA
Genome Projectfever generation
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001934
IDA
NAS
Genome Projectpositive regulation of protein phosphorylation
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002437
IBA
Genome Projectinflammatory response to antigenic stimulus
GO:0002439
IEA
Genome Projectchronic inflammatory response to antigenic stimulus
GO:0002711
IC
Genome Projectpositive regulation of T cell mediated immunity
GO:0006144
IEA
Genome Projectpurine nucleobase metabolic process
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006954
IDA
NAS, IEA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007204
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007566
TAS
Genome Projectembryo implantation
GO:0007568
IEA
Genome Projectaging
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0007611
IEA
Genome Projectlearning or memory
GO:0007613
IEA
Genome Projectmemory
GO:0008210
IEA
Genome Projectestrogen metabolic process
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0009100
IEA
Genome Projectglycoprotein metabolic process
GO:0009408
IEA
Genome Projectresponse to heat
GO:0009743
IEA
Genome Projectresponse to carbohydrate
GO:0010193
IEA
Genome Projectresponse to ozone
GO:0010243
IEA
Genome Projectresponse to organonitrogen compound
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010575
IDA
ISS
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010628
IDA
IEA
Genome Projectpositive regulation of gene expression
GO:0010629
IEA
Genome Projectnegative regulation of gene expression
GO:0010829
ISS
IEA
Genome Projectnegative regulation of glucose transport
GO:0010942
IEA
Genome Projectpositive regulation of cell death
GO:0014050
IEA
Genome Projectnegative regulation of glutamate secretion
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0014805
NAS
Genome Projectsmooth muscle adaptation
GO:0019221
IDA
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0019742
IEA
Genome Projectpentacyclic triterpenoid metabolic process
GO:0030213
IDA
Genome Projecthyaluronan biosynthetic process
GO:0030593
IEA
Genome Projectneutrophil chemotaxis
GO:0030638
IEA
Genome Projectpolyketide metabolic process
GO:0030728
IEA
Genome Projectovulation
GO:0030730
IDA
Genome Projectsequestering of triglyceride
GO:0030949
IC
Genome Projectpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031622
ISS
IEA
Genome Projectpositive regulation of fever generation
GO:0031663
IDA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032308
ISS
IEA
Genome Projectpositive regulation of prostaglandin secretion
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032611
IEA
Genome Projectinterleukin-1 beta production
GO:0032725
IDA
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729
IDA
Genome Projectpositive regulation of interferon-gamma production
GO:0032755
TAS, IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0032874
IEA
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0033092
IEA
Genome Projectpositive regulation of immature T cell proliferation in thymus
GO:0033129
NAS
Genome Projectpositive regulation of histone phosphorylation
GO:0033198
IEA
Genome Projectresponse to ATP
GO:0033280
IEA
Genome Projectresponse to vitamin D
GO:0033591
IEA
Genome Projectresponse to L-ascorbic acid
GO:0034116
IDA
NAS
Genome Projectpositive regulation of heterotypic cell-cell adhesion
GO:0035066
NAS
Genome Projectpositive regulation of histone acetylation
GO:0035176
IEA
Genome Projectsocial behavior
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0035505
IDA
Genome Projectpositive regulation of myosin light chain kinase activity
GO:0035634
IEA
Genome Projectresponse to stilbenoid
GO:0035690
IDA
Genome Projectcellular response to drug
GO:0036270
IEA
Genome Projectresponse to diuretic
GO:0036273
IEA
Genome Projectresponse to statin
GO:0042060
IEA
Genome Projectwound healing
GO:0042102
IDA
Genome Projectpositive regulation of T cell proliferation
GO:0042346
IDA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043122
IDA
Genome Projectregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278
IEA
Genome Projectresponse to morphine
GO:0043407
ISS
IEA
Genome Projectnegative regulation of MAP kinase activity
GO:0043434
IEA
Genome Projectresponse to peptide hormone
GO:0043491
IMP
Genome Projectprotein kinase B signaling
GO:0043507
IEA
Genome Projectpositive regulation of JUN kinase activity
GO:0045080
IEA
Genome Projectpositive regulation of chemokine biosynthetic process
GO:0045086
IMP
Genome Projectpositive regulation of interleukin-2 biosynthetic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045410
IEA
Genome Projectpositive regulation of interleukin-6 biosynthetic process
GO:0045429
IDA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045665
IEA
Genome Projectnegative regulation of neuron differentiation
GO:0045687
IEA
Genome Projectpositive regulation of glial cell differentiation
GO:0045766
ISS
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045833
ISS
IEA
Genome Projectnegative regulation of lipid metabolic process
GO:0045840
IMP
Genome Projectpositive regulation of mitotic nuclear division
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IEA
Genome Projectpositive regulation of JNK cascade
GO:0046627
ISS
IEA
Genome Projectnegative regulation of insulin receptor signaling pathway
GO:0046827
NAS
Genome Projectpositive regulation of protein export from nucleus
GO:0048711
IEA
Genome Projectpositive regulation of astrocyte differentiation
GO:0050766
IMP
Genome Projectpositive regulation of phagocytosis
GO:0050768
IEA
Genome Projectnegative regulation of neurogenesis
GO:0050796
IDA
Genome Projectregulation of insulin secretion
GO:0050900
IEA
Genome Projectleukocyte migration
GO:0050995
IDA
Genome Projectnegative regulation of lipid catabolic process
GO:0050996
ISS
IEA
Genome Projectpositive regulation of lipid catabolic process
GO:0051044
IDA
Genome Projectpositive regulation of membrane protein ectodomain proteolysis
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051781
IEA
Genome Projectpositive regulation of cell division
GO:0060355
NAS
Genome Projectpositive regulation of cell adhesion molecule production
GO:0060559
IDA
Genome Projectpositive regulation of calcidiol 1-monooxygenase activity
GO:0070164
ISS
IEA
Genome Projectnegative regulation of adiponectin secretion
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070487
IDA
Genome Projectmonocyte aggregation
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071236
IEA
Genome Projectcellular response to antibiotic
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071310
IDA
Genome Projectcellular response to organic substance
GO:0071333
IEA
Genome Projectcellular response to glucose stimulus
GO:0071396
IEA
Genome Projectcellular response to lipid
GO:0071398
IEA
Genome Projectcellular response to fatty acid
GO:0071407
IDA
Genome Projectcellular response to organic cyclic compound
GO:0071414
IEA
Genome Projectcellular response to methotrexate
GO:0071548
IEA
Genome Projectresponse to dexamethasone
GO:0071639
IDA
Genome Projectpositive regulation of monocyte chemotactic protein-1 production
GO:0090023
IEA
Genome Projectpositive regulation of neutrophil chemotaxis
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:2000173
IEA
Genome Projectnegative regulation of branching morphogenesis of a nerve
GO:2000178
IEA
Genome Projectnegative regulation of neural precursor cell proliferation
GO:2001240
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005125
IDA, IMP
IEA
Genome Projectcytokine activity
GO:0005149
IBA
NAS, IEA
Genome Projectinterleukin-1 receptor binding
GO:0019904
IPI
Genome Projectprotein domain specific binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
TAS, NAS, IEA
Genome Projectextracellular region
GO:0005615
IDA, IMP
IEA
Genome Projectextracellular space
GO:0005829
TAS
Genome Projectcytosol
GO:0030141
IEA
Genome Projectsecretory granule
GO:0031982
IEA
Genome Projectvesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000975Interleukin-1 family
IPR003294Interleukin-1 alpha/beta
IPR003296Interleukin-1 beta
IPR003502Interleukin-1 propeptide
IPR008996Cytokine, IL-1-like
IPR020877Interleukin-1 conserved site
IPR028142IL-1 family/FGF family

No MapMan annotations defined for this gene.