Gene: ENSG00000125378 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125378
Transcript Identifier
ENST00000558984
Gene Type
Coding gene
Location
14 : 53950032-53952222 : negative

Family Information

Homologous gene family
HOM03P001000
(62 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P063641
(2 genes in 2 species)
specific family

Descriptions

gene_descr
bone morphogenetic protein 4

Identifiers

Type Value
pidENSP00000454134
HGNC1071
UniprotP12644
UniprotQ53XC5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000186
IDA
Genome Projectactivation of MAPKK activity
GO:0001501
IEA
Genome Projectskeletal system development
GO:0001503
IEA
Genome Projectossification
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001541
IEA
Genome Projectovarian follicle development
GO:0001568
IEA
Genome Projectblood vessel development
GO:0001649
IDA
Genome Projectosteoblast differentiation
GO:0001656
IEA
Genome Projectmetanephros development
GO:0001657
IDA
Genome Projectureteric bud development
GO:0001658
IDA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001707
IEA
Genome Projectmesoderm formation
GO:0001759
IEA
Genome Projectorgan induction
GO:0001822
IMP
Genome Projectkidney development
GO:0001823
IEP
Genome Projectmesonephros development
GO:0001843
IEA
Genome Projectneural tube closure
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
IDA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001944
IEA
Genome Projectvasculature development
GO:0001958
ISS
IEA
Genome Projectendochondral ossification
GO:0002043
IDA
Genome Projectblood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062
ISS
IEA
Genome Projectchondrocyte differentiation
GO:0002244
IDA
Genome Projecthematopoietic progenitor cell differentiation
GO:0002320
IMP
Genome Projectlymphoid progenitor cell differentiation
GO:0003014
IEA
Genome Projectrenal system process
GO:0003130
IMP
Genome ProjectBMP signaling pathway involved in heart induction
GO:0003139
IMP
Genome Projectsecondary heart field specification
GO:0003197
TAS
Genome Projectendocardial cushion development
GO:0003279
TAS
Genome Projectcardiac septum development
GO:0003323
IDA
Genome Projecttype B pancreatic cell development
GO:0003337
IDA
Genome Projectmesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182
IDA
Genome Projectcommon-partner SMAD protein phosphorylation
GO:0007224
IEP
Genome Projectsmoothened signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007281
IEA
Genome Projectgerm cell development
GO:0007420
IEA
Genome Projectbrain development
GO:0007500
IEA
Genome Projectmesodermal cell fate determination
GO:0007507
IEA
Genome Projectheart development
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IDA
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009791
IDA
Genome Projectpost-embryonic development
GO:0009888
IEA
Genome Projecttissue development
GO:0009948
IEA
Genome Projectanterior/posterior axis specification
GO:0010159
IEA
Genome Projectspecification of organ position
GO:0010453
IDA
Genome Projectregulation of cell fate commitment
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010524
IEA
Genome Projectpositive regulation of calcium ion transport into cytosol
GO:0010595
IDA
Genome Projectpositive regulation of endothelial cell migration
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010629
IEA
Genome Projectnegative regulation of gene expression
GO:0010862
IDA, IMP
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942
IDA
Genome Projectpositive regulation of cell death
GO:0010976
IEA
Genome Projectpositive regulation of neuron projection development
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0021537
IDA
Genome Projecttelencephalon development
GO:0021904
IEA
Genome Projectdorsal/ventral neural tube patterning
GO:0021978
IEA
Genome Projecttelencephalon regionalization
GO:0021983
IEA
Genome Projectpituitary gland development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030218
IEA
Genome Projecterythrocyte differentiation
GO:0030224
IDA
Genome Projectmonocyte differentiation
GO:0030225
IDA
Genome Projectmacrophage differentiation
GO:0030324
IEA
Genome Projectlung development
GO:0030326
IEA
Genome Projectembryonic limb morphogenesis
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0030501
IDA
IEA
Genome Projectpositive regulation of bone mineralization
GO:0030509
IDA, IMP
Genome ProjectBMP signaling pathway
GO:0030513
ISS
IEA
Genome Projectpositive regulation of BMP signaling pathway
GO:0030900
IEA
Genome Projectforebrain development
GO:0032092
IDA
Genome Projectpositive regulation of protein binding
GO:0032331
IEA
Genome Projectnegative regulation of chondrocyte differentiation
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032526
IEA
Genome Projectresponse to retinoic acid
GO:0032967
IDA
Genome Projectpositive regulation of collagen biosynthetic process
GO:0033085
IMP
Genome Projectnegative regulation of T cell differentiation in thymus
GO:0033088
IMP
Genome Projectnegative regulation of immature T cell proliferation in thymus
GO:0033574
IEA
Genome Projectresponse to testosterone
GO:0034504
IDA
Genome Projectprotein localization to nucleus
GO:0034599
IEA
Genome Projectcellular response to oxidative stress
GO:0035116
IEA
Genome Projectembryonic hindlimb morphogenesis
GO:0035990
ISS
IEA
Genome Projecttendon cell differentiation
GO:0035993
ISS
IEA
Genome Projectdeltoid tuberosity development
GO:0040007
IEA
Genome Projectgrowth
GO:0042060
IEA
Genome Projectwound healing
GO:0042306
IDA
Genome Projectregulation of protein import into nucleus
GO:0042326
IDA
Genome Projectnegative regulation of phosphorylation
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0042476
IGI
IEA
Genome Projectodontogenesis
GO:0042487
IEA
Genome Projectregulation of odontogenesis of dentin-containing tooth
GO:0042733
IEA
Genome Projectembryonic digit morphogenesis
GO:0043010
IEA
Genome Projectcamera-type eye development
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043401
IMP
Genome Projectsteroid hormone mediated signaling pathway
GO:0043407
IDA
Genome Projectnegative regulation of MAP kinase activity
GO:0043587
IEA
Genome Projecttongue morphogenesis
GO:0045165
IEA
Genome Projectcell fate commitment
GO:0045595
IEA
Genome Projectregulation of cell differentiation
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0045603
IEA
Genome Projectpositive regulation of endothelial cell differentiation
GO:0045606
IDA
Genome Projectpositive regulation of epidermal cell differentiation
GO:0045662
IDA
Genome Projectnegative regulation of myoblast differentiation
GO:0045666
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0045669
IDA
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045778
IDA
IEA
Genome Projectpositive regulation of ossification
GO:0045786
IDA
Genome Projectnegative regulation of cell cycle
GO:0045839
IDA
Genome Projectnegative regulation of mitotic nuclear division
GO:0045843
IDA
Genome Projectnegative regulation of striated muscle tissue development
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048286
IDA
Genome Projectlung alveolus development
GO:0048333
IEA
Genome Projectmesodermal cell differentiation
GO:0048392
IDA
Genome Projectintermediate mesodermal cell differentiation
GO:0048593
IEA
Genome Projectcamera-type eye morphogenesis
GO:0048598
IEA
Genome Projectembryonic morphogenesis
GO:0048646
IEA
Genome Projectanatomical structure formation involved in morphogenesis
GO:0048660
IEA
Genome Projectregulation of smooth muscle cell proliferation
GO:0048661
IDA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0048663
IEA
Genome Projectneuron fate commitment
GO:0048701
IEA
Genome Projectembryonic cranial skeleton morphogenesis
GO:0048704
IEA
Genome Projectembryonic skeletal system morphogenesis
GO:0048706
IEA
Genome Projectembryonic skeletal system development
GO:0048715
IEA
Genome Projectnegative regulation of oligodendrocyte differentiation
GO:0048745
ISS
IEA
Genome Projectsmooth muscle tissue development
GO:0048754
IDA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0050679
IDA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050680
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050918
IDA
Genome Projectpositive chemotaxis
GO:0051145
IEA
Genome Projectsmooth muscle cell differentiation
GO:0051150
IEA
Genome Projectregulation of smooth muscle cell differentiation
GO:0051216
IEA
Genome Projectcartilage development
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0055020
IMP
Genome Projectpositive regulation of cardiac muscle fiber development
GO:0060033
IEA
Genome Projectanatomical structure regression
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0060113
IEA
Genome Projectinner ear receptor cell differentiation
GO:0060197
IEA
Genome Projectcloacal septation
GO:0060235
IEA
Genome Projectlens induction in camera-type eye
GO:0060272
IEA
Genome Projectembryonic skeletal joint morphogenesis
GO:0060348
IEA
Genome Projectbone development
GO:0060363
IEA
Genome Projectcranial suture morphogenesis
GO:0060391
IDA
Genome Projectpositive regulation of SMAD protein import into nucleus
GO:0060393
IDA
Genome Projectregulation of pathway-restricted SMAD protein phosphorylation
GO:0060395
IDA
Genome ProjectSMAD protein signal transduction
GO:0060425
IDA
Genome Projectlung morphogenesis
GO:0060429
IEA
Genome Projectepithelium development
GO:0060433
IDA
Genome Projectbronchus development
GO:0060438
IDA
Genome Projecttrachea development
GO:0060440
IEA
Genome Projecttrachea formation
GO:0060441
IDA
IEA
Genome Projectepithelial tube branching involved in lung morphogenesis
GO:0060442
IEA
Genome Projectbranching involved in prostate gland morphogenesis
GO:0060449
IEA
Genome Projectbud elongation involved in lung branching
GO:0060462
IEA
Genome Projectlung lobe development
GO:0060502
IDA
Genome Projectepithelial cell proliferation involved in lung morphogenesis
GO:0060503
IDA
Genome Projectbud dilation involved in lung branching
GO:0060512
IEA
Genome Projectprostate gland morphogenesis
GO:0060548
IDA
Genome Projectnegative regulation of cell death
GO:0060592
IEA
Genome Projectmammary gland formation
GO:0060684
IEA
Genome Projectepithelial-mesenchymal cell signaling
GO:0060686
IEA
Genome Projectnegative regulation of prostatic bud formation
GO:0060687
IEA
Genome Projectregulation of branching involved in prostate gland morphogenesis
GO:0060688
IEA
Genome Projectregulation of morphogenesis of a branching structure
GO:0061035
IEA
Genome Projectregulation of cartilage development
GO:0061036
IDA
Genome Projectpositive regulation of cartilage development
GO:0061047
ISS
IEA
Genome Projectpositive regulation of branching involved in lung morphogenesis
GO:0061149
ISS
IEA
Genome ProjectBMP signaling pathway involved in ureter morphogenesis
GO:0061151
ISS
IEA
Genome ProjectBMP signaling pathway involved in renal system segmentation
GO:0061155
IDA
Genome Projectpulmonary artery endothelial tube morphogenesis
GO:0070244
IMP
Genome Projectnegative regulation of thymocyte apoptotic process
GO:0070368
IEA
Genome Projectpositive regulation of hepatocyte differentiation
GO:0070372
IEA
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071731
IEA
Genome Projectresponse to nitric oxide
GO:0071773
IMP
IEA
Genome Projectcellular response to BMP stimulus
GO:0071893
IDA
Genome ProjectBMP signaling pathway involved in nephric duct formation
GO:0072001
IEP
IEA
Genome Projectrenal system development
GO:0072015
IEA
Genome Projectglomerular visceral epithelial cell development
GO:0072097
IDA
Genome Projectnegative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101
IDA
Genome Projectspecification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104
ISS
IEA
Genome Projectglomerular capillary formation
GO:0072125
IDA
Genome Projectnegative regulation of glomerular mesangial cell proliferation
GO:0072138
IEA
Genome Projectmesenchymal cell proliferation involved in ureteric bud development
GO:0072161
IEA
Genome Projectmesenchymal cell differentiation involved in kidney development
GO:0072192
ISS
IEA
Genome Projectureter epithelial cell differentiation
GO:0072193
ISS
IEA
Genome Projectureter smooth muscle cell differentiation
GO:0072198
IEA
Genome Projectmesenchymal cell proliferation involved in ureter development
GO:0072200
IDA
Genome Projectnegative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205
ISS
IEA
Genome Projectmetanephric collecting duct development
GO:0090184
IDA
Genome Projectpositive regulation of kidney development
GO:0090191
IDA
Genome Projectnegative regulation of branching involved in ureteric bud morphogenesis
GO:0090194
IDA
Genome Projectnegative regulation of glomerulus development
GO:0097067
IEA
Genome Projectcellular response to thyroid hormone stimulus
GO:1901341
IEA
Genome Projectpositive regulation of store-operated calcium channel activity
GO:1902462
IEA
Genome Projectpositive regulation of mesenchymal stem cell proliferation
GO:2000005
IDA
Genome Projectnegative regulation of metanephric S-shaped body morphogenesis
GO:2000007
IDA
Genome Projectnegative regulation of metanephric comma-shaped body morphogenesis
GO:2000105
IDA
Genome Projectpositive regulation of DNA-dependent DNA replication
GO:2000137
IMP
Genome Projectnegative regulation of cell proliferation involved in heart morphogenesis
GO:2000353
IEA
Genome Projectpositive regulation of endothelial cell apoptotic process
GO:2001012
IEA
Genome Projectmesenchymal cell differentiation involved in renal system development

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
IDA
IEA
Genome Projectcytokine activity
GO:0005160
IBA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0008201
IEA
Genome Projectheparin binding
GO:0039706
IPI
Genome Projectco-receptor binding
GO:0042056
IDA
Genome Projectchemoattractant activity
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0070700
IDA
Genome ProjectBMP receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
ISS
TAS, IEA
Genome Projectextracellular region
GO:0005578
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IDA
ISS, IBA
IEA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0031988
IEA
Genome Projectmembrane-bounded vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR015615Transforming growth factor-beta-related
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.