Gene: ENSG00000125347 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125347
Transcript Identifier
ENST00000405885
Gene Type
Coding gene
Location
5 : 132483951-132489478 : negative

Family Information

Homologous gene family
HOM03P027526
(3 genes in 2 species)
specific family

Descriptions

gene_descr
interferon regulatory factor 1

Identifiers

Type Value
pidENSP00000384406
HGNC6116
UniprotP10914
UniprotQ6FHN8

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002376
IEA
Genome Projectimmune system process
GO:0002819
TAS
Genome Projectregulation of adaptive immune response
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
TAS
Genome Projecttranscription from RNA polymerase II promoter
GO:0006915
IDA
Genome Projectapoptotic process
GO:0007050
IDA
Genome Projectcell cycle arrest
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008285
TAS
Genome Projectnegative regulation of cell proliferation
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0019221
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0032481
ISS
IEA
Genome Projectpositive regulation of type I interferon production
GO:0032728
IMP
Genome Projectpositive regulation of interferon-beta production
GO:0034124
ISS
IEA
Genome Projectregulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458
IDA
Genome Projectcellular response to interferon-beta
GO:0043374
IEA
Genome ProjectCD8-positive, alpha-beta T cell differentiation
GO:0045084
IEA
Genome Projectpositive regulation of interleukin-12 biosynthetic process
GO:0045087
IEA
Genome Projectinnate immune response
GO:0045088
TAS
Genome Projectregulation of innate immune response
GO:0045590
ISS
IEA
Genome Projectnegative regulation of regulatory T cell differentiation
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA, IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0051607
IDA
IEA
Genome Projectdefense response to virus
GO:0051726
TAS
Genome Projectregulation of cell cycle
GO:0060333
ISS
TAS, IEA
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060337
TAS
Genome Projecttype I interferon signaling pathway
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:2000564
ISS
IEA
Genome Projectregulation of CD8-positive, alpha-beta T cell proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000975
IEA
Genome Projectregulatory region DNA binding
GO:0000978
IDA, IMP
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077
IMP
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677
TAS, IEA
Genome ProjectDNA binding
GO:0003700
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0043565
IEA
Genome Projectsequence-specific DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0005634
TAS, IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
ISS
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001346Interferon regulatory factor DNA-binding domain
IPR011991Winged helix-turn-helix DNA-binding domain
IPR017431Interferon regulatory factor-1/2
IPR019817Interferon regulatory factor, conserved site
IPR031215Interferon regulatory factor 1

No MapMan annotations defined for this gene.