Gene: ENSG00000124493 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000124493
Transcript Identifier
ENST00000538487
Gene Type
Coding gene
Location
6 : 34022821-34133496 : negative

Family Information

Homologous gene family
HOM03P000228
(156 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P004612
(18 genes in 4 species)
specific family

Descriptions

gene_descr
glutamate receptor, metabotropic 4

Identifiers

Type Value
pidENSP00000440556
HGNC4596
UniprotQ14833
UniprotA1L4F9

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007268
TAS, IEA
Genome Projectsynaptic transmission
GO:0007612
IEA
Genome Projectlearning
GO:0000187
IDA
Genome Projectactivation of MAPK activity
GO:0007196
IMP
Genome Projectadenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007269
TAS
Genome Projectneurotransmitter secretion
GO:0043410
IEP
Genome Projectpositive regulation of MAPK cascade
GO:0043523
TAS
Genome Projectregulation of neuron apoptotic process
GO:0051966
IBA
Genome Projectregulation of synaptic transmission, glutamatergic

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
IMP
IEA
Genome ProjectG-protein coupled receptor activity
GO:0001642
IBA
Genome Projectgroup III metabotropic glutamate receptor activity
GO:0008066
IMP
Genome Projectglutamate receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0005622
IDA
Genome Projectintracellular
GO:0005887
IDA
TAS
Genome Projectintegral component of plasma membrane
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0042734
IBA
Genome Projectpresynaptic membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000162GPCR, family 3, metabotropic glutamate receptor
IPR000337GPCR, family 3
IPR001786GPCR, family 3, metabotropic glutamate receptor 4
IPR001828Receptor, ligand binding region
IPR011500GPCR, family 3, nine cysteines domain
IPR017978GPCR family 3, C-terminal
IPR017979GPCR, family 3, conserved site
IPR028082Periplasmic binding protein-like I

No MapMan annotations defined for this gene.