Gene: ENSG00000124181 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000124181
Transcript Identifier
ENST00000244007
Gene Type
Coding gene
Location
20 : 41137642-41174509 : positive

Family Information

Homologous gene family
HOM03P000424
(107 genes in 28 species)
specific family
Orthologous gene family
ORTHO03P014366
(6 genes in 4 species)
specific family

Descriptions

gene_descr
phospholipase C, gamma 1

Identifiers

Type Value
pidENSP00000244007
HGNC9065
UniprotP19174

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
TAS
Genome Projectactivation of MAPKK activity
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0007165
TAS, NAS, IEA
Genome Projectsignal transduction
GO:0007173
IMP
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007202
TAS
Genome Projectactivation of phospholipase C activity
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0009395
IEA
Genome Projectphospholipid catabolic process
GO:0010634
IMP
Genome Projectpositive regulation of epithelial cell migration
GO:0016032
IEA
Genome Projectviral process
GO:0016042
IEA
Genome Projectlipid catabolic process
GO:0016477
IMP
Genome Projectcell migration
GO:0019221
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0019722
IMP
Genome Projectcalcium-mediated signaling
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0043536
IDA
Genome Projectpositive regulation of blood vessel endothelial cell migration
GO:0043647
TAS
Genome Projectinositol phosphate metabolic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045766
IDA
Genome Projectpositive regulation of angiogenesis
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050852
TAS, IEA
Genome ProjectT cell receptor signaling pathway
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0051281
IMP
Genome Projectpositive regulation of release of sequestered calcium ion into cytosol
GO:0071364
IDA, IMP
Genome Projectcellular response to epidermal growth factor stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004435
IDA
TAS, IEA
Genome Projectphosphatidylinositol phospholipase C activity
GO:0004629
TAS
Genome Projectphospholipase C activity
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0005057
NAS
Genome Projectreceptor signaling protein activity
GO:0005168
IPI
Genome Projectneurotrophin TRKA receptor binding
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008081
IEA
Genome Projectphosphoric diester hydrolase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0030971
IEA
Genome Projectreceptor tyrosine kinase binding
GO:0035254
IEA
Genome Projectglutamate receptor binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001726
IDA
IEA
Genome Projectruffle
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005911
IEA
Genome Projectcell-cell junction
GO:0008180
IDA
Genome ProjectCOP9 signalosome
GO:0030027
IDA
IEA
Genome Projectlamellipodium
GO:0042995
IDA
IEA
Genome Projectcell projection

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000008C2 domain
IPR000909Phosphatidylinositol-specific phospholipase C, X domain
IPR000980SH2 domain
IPR001192Phosphoinositide phospholipase C family
IPR001452SH3 domain
IPR001711Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849Pleckstrin homology domain
IPR002048EF-hand domain
IPR011992EF-hand domain pair
IPR011993PH domain-like
IPR016279Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR017946PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR018247EF-Hand 1, calcium-binding site
IPR0283801-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

No MapMan annotations defined for this gene.