Gene: ENSG00000123104 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000123104
Transcript Identifier
ENST00000381340
Gene Type
Coding gene
Location
12 : 26339397-26832781 : negative

Family Information

Homologous gene family
HOM03P001263
(54 genes in 8 species)
specific family
Orthologous gene family
ORTHO03P008296
(10 genes in 6 species)
specific family

Descriptions

gene_descr
inositol 1,4,5-trisphosphate receptor, type 2

Identifiers

Type Value
pidENSP00000370744
HGNC6181
UniprotQ14571

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IDA
Genome Projectresponse to hypoxia
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0006112
TAS
Genome Projectenergy reserve metabolic process
GO:0006810
TAS, IEA
Genome Projecttransport
GO:0006811
IEA
Genome Projection transport
GO:0006816
IEA
Genome Projectcalcium ion transport
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007202
TAS
Genome Projectactivation of phospholipase C activity
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0030168
TAS
Genome Projectplatelet activation
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048016
TAS, IEA
Genome Projectinositol phosphate-mediated signaling
GO:0050796
TAS
Genome Projectregulation of insulin secretion
GO:0055085
IEA
Genome Projecttransmembrane transport
GO:0070588
IEA
Genome Projectcalcium ion transmembrane transport
GO:0071320
IEA
Genome Projectcellular response to cAMP
GO:0071361
IEA
Genome Projectcellular response to ethanol

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005216
IEA
Genome Projection channel activity
GO:0005220
TAS, IEA
Genome Projectinositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262
IEA
Genome Projectcalcium channel activity
GO:0015085
TAS
Genome Projectcalcium ion transmembrane transporter activity
GO:0015278
IEA
Genome Projectcalcium-release channel activity
GO:0035091
IEA
Genome Projectphosphatidylinositol binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005789
TAS, IEA
Genome Projectendoplasmic reticulum membrane
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005938
IEA
Genome Projectcell cortex
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016529
IEA
Genome Projectsarcoplasmic reticulum
GO:0031095
TAS
Genome Projectplatelet dense tubular network membrane
GO:0033017
IMP
Genome Projectsarcoplasmic reticulum membrane
GO:0043235
IDA
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000493Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699RIH (RyR and IP3R Homology) domain
IPR005821Ion transport domain
IPR013662RyR/IP3R Homology associated domain
IPR014821Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR015925Ryanodine receptor-related
IPR016024Armadillo-type fold
IPR016093MIR motif

No MapMan annotations defined for this gene.