Gene: ENSG00000122884 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000122884
Transcript Identifier
ENST00000263556
Gene Type
Coding gene
Location
10 : 73008222-73074883 : negative

Family Information

Homologous gene family
HOM03P000081
(327 genes in 33 species)
specific family
Orthologous gene family
ORTHO03P006772
(12 genes in 8 species)
specific family

Descriptions

gene_descr
prolyl 4-hydroxylase, alpha polypeptide I

Identifiers

Type Value
pidENSP00000263556
HGNC8546
UniprotP13674
UniprotQ5VSQ6

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0018401
IEA
Genome Projectpeptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030199
IEA
Genome Projectcollagen fibril organization
GO:0055114
IEA
Genome Projectoxidation-reduction process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004656
TAS, IEA
Genome Projectprocollagen-proline 4-dioxygenase activity
GO:0005506
IEA
Genome Projectiron ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0016491
IEA
Genome Projectoxidoreductase activity
GO:0016702
IEA
Genome Projectoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705
IEA
Genome Projectoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706
IEA
Genome Projectoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418
IEA
Genome ProjectL-ascorbic acid binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0051213
IEA
Genome Projectdioxygenase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005783
IDA
TAS, IEA
Genome Projectendoplasmic reticulum
GO:0005788
IEA
Genome Projectendoplasmic reticulum lumen
GO:0016020
IDA
Genome Projectmembrane
GO:0016222
IEA
Genome Projectprocollagen-proline 4-dioxygenase complex
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0005581
IEA
Genome Projectcollagen trimer

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR005123Oxoglutarate/iron-dependent dioxygenase
IPR006620Prolyl 4-hydroxylase, alpha subunit
IPR011990Tetratricopeptide-like helical domain
IPR013026Tetratricopeptide repeat-containing domain
IPR013547Prolyl 4-hydroxylase alpha-subunit, N-terminal
IPR019734Tetratricopeptide repeat

No MapMan annotations defined for this gene.