Gene: ENSG00000121966 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000121966
Transcript Identifier
ENST00000409817
Gene Type
Coding gene
Location
2 : 136114869-136115939 : negative

Family Information

Homologous gene family
HOM03P000080
(330 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P073877
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
chemokine (C-X-C motif) receptor 4

Identifiers

Type Value
pidENSP00000386884
HGNC2561
UniprotP61073

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0001666
IEP
Genome Projectresponse to hypoxia
GO:0002407
TAS
Genome Projectdendritic cell chemotaxis
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006935
IEA
Genome Projectchemotaxis
GO:0006954
TAS
Genome Projectinflammatory response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IDA
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007204
TAS
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0009615
TAS
Genome Projectresponse to virus
GO:0016032
TAS, IEA
Genome Projectviral process
GO:0019722
IMP
Genome Projectcalcium-mediated signaling
GO:0030260
TAS
Genome Projectentry into host cell
GO:0042119
IEA
Genome Projectneutrophil activation
GO:0043217
ISS
Genome Projectmyelin maintenance
GO:0046718
IEA
Genome Projectviral entry into host cell
GO:0048714
ISS
Genome Projectpositive regulation of oligodendrocyte differentiation
GO:0050920
IMP
Genome Projectregulation of chemotaxis
GO:0070098
NAS, IEA
Genome Projectchemokine-mediated signaling pathway
GO:0071345
IDA
Genome Projectcellular response to cytokine stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001618
IEA
Genome Projectvirus receptor activity
GO:0003779
IDA
Genome Projectactin binding
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
TAS, IEA
Genome ProjectG-protein coupled receptor activity
GO:0004950
IEA
Genome Projectchemokine receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0015026
TAS
Genome Projectcoreceptor activity
GO:0016494
NAS, IEA
Genome ProjectC-X-C chemokine receptor activity
GO:0019955
IEA
Genome Projectcytokine binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0032027
IDA
Genome Projectmyosin light chain binding
GO:0043130
IDA
Genome Projectubiquitin binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
TAS
Genome Projectcytoplasm
GO:0005764
IDA
IEA
Genome Projectlysosome
GO:0005768
IEA
Genome Projectendosome
GO:0005769
IDA
IEA
Genome Projectearly endosome
GO:0005770
IDA
IEA
Genome Projectlate endosome
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016023
IDA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0030054
IEA
Genome Projectcell junction
GO:0031252
IDA
Genome Projectcell leading edge
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR000355Chemokine receptor family
IPR001277CXC chemokine receptor 4
IPR017452GPCR, rhodopsin-like, 7TM
IPR022726CXC chemokine receptor 4 N-terminal domain

No MapMan annotations defined for this gene.