Gene: ENSG00000121858 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000121858
Transcript Identifier
ENST00000241261
Gene Type
Coding gene
Location
3 : 172506492-172523384 : negative

Family Information

Homologous gene family
HOM03P032491
(2 genes in 2 species)
specific family

Descriptions

gene_descr
tumor necrosis factor (ligand) superfamily, member 10

Identifiers

Type Value
pidENSP00000241261
HGNC11925
UniprotP50591
UniprotQ6IBA9

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955
IEA
Genome Projectimmune response
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0010939
TAS
Genome Projectregulation of necrotic cell death
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154
TAS
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070266
TAS
Genome Projectnecroptotic process
GO:0090200
IDA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0097191
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300
TAS
Genome Projectprogrammed necrotic cell death
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001238
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
TAS
Genome Projectreceptor binding
GO:0005125
IEA
Genome Projectcytokine activity
GO:0005164
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0032813
IEA
Genome Projecttumor necrosis factor receptor superfamily binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS
Genome Projectextracellular region
GO:0005615
IEA
Genome Projectextracellular space
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006052Tumour necrosis factor domain
IPR008983Tumour necrosis factor-like domain
IPR017355Tumour necrosis factor ligand 10/11
IPR021184Tumour necrosis factor, conserved site

No MapMan annotations defined for this gene.