Gene: ENSG00000121807 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000121807
Transcript Identifier
ENST00000400888
Gene Type
Coding gene
Location
3 : 46357528-46359860 : positive

Family Information

Homologous gene family
HOM03P000080
(330 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P070300
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
chemokine (C-C motif) receptor 2

Identifiers

Type Value
pidENSP00000383681
HGNC1603
UniprotP41597

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001974
ISS
IEA
Genome Projectblood vessel remodeling
GO:0002407
TAS
Genome Projectdendritic cell chemotaxis
GO:0002827
ISS
Genome Projectpositive regulation of T-helper 1 type immune response
GO:0002829
ISS
Genome Projectnegative regulation of type 2 immune response
GO:0006874
ISS
Genome Projectcellular calcium ion homeostasis
GO:0006935
TAS, IEA
Genome Projectchemotaxis
GO:0006954
TAS, IEA
Genome Projectinflammatory response
GO:0006955
TAS, IEA
Genome Projectimmune response
GO:0006968
TAS
Genome Projectcellular defense response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007194
TAS
Genome Projectnegative regulation of adenylate cyclase activity
GO:0007204
TAS
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007259
TAS
Genome ProjectJAK-STAT cascade
GO:0009611
TAS
Genome Projectresponse to wounding
GO:0010574
ISS
Genome Projectregulation of vascular endothelial growth factor production
GO:0010820
ISS
Genome Projectpositive regulation of T cell chemotaxis
GO:0016032
IEA
Genome Projectviral process
GO:0016525
ISS
Genome Projectnegative regulation of angiogenesis
GO:0019221
IDA
Genome Projectcytokine-mediated signaling pathway
GO:0019725
ISS
Genome Projectcellular homeostasis
GO:0032729
ISS
Genome Projectpositive regulation of interferon-gamma production
GO:0032743
ISS
Genome Projectpositive regulation of interleukin-2 production
GO:0035705
ISS
Genome ProjectT-helper 17 cell chemotaxis
GO:0042535
ISS
Genome Projectpositive regulation of tumor necrosis factor biosynthetic process
GO:0043310
ISS
Genome Projectnegative regulation of eosinophil degranulation
GO:0045087
TAS
Genome Projectinnate immune response
GO:0046641
ISS
Genome Projectpositive regulation of alpha-beta T cell proliferation
GO:0050729
ISS
Genome Projectpositive regulation of inflammatory response
GO:0050870
ISS
Genome Projectpositive regulation of T cell activation
GO:0070098
ISS
Genome Projectchemokine-mediated signaling pathway
GO:0090026
IDA
ISS
IEA
Genome Projectpositive regulation of monocyte chemotaxis
GO:0090265
ISS
Genome Projectpositive regulation of immune complex clearance by monocytes and macrophages
GO:2000439
ISS
Genome Projectpositive regulation of monocyte extravasation
GO:2000451
ISS
Genome Projectpositive regulation of CD8-positive, alpha-beta T cell extravasation
GO:2000464
IDA
Genome Projectpositive regulation of astrocyte chemotaxis
GO:2000473
ISS
Genome Projectpositive regulation of hematopoietic stem cell migration

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
IEA
Genome ProjectG-protein coupled receptor activity
GO:0004950
TAS, IEA
Genome Projectchemokine receptor activity
GO:0016493
IEA
Genome ProjectC-C chemokine receptor activity
GO:0031727
IDA
Genome ProjectCCR2 chemokine receptor binding
GO:0042803
ISS
Genome Projectprotein homodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
ISS
Genome Projectcytosol
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
TAS, IEA
Genome Projectintegral component of membrane
GO:0030425
ISS
Genome Projectdendrite
GO:0043025
ISS
Genome Projectneuronal cell body
GO:0043204
ISS
Genome Projectperikaryon
GO:0048471
ISS
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR000355Chemokine receptor family
IPR002237CC chemokine receptor 2
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.