Gene: ENSG00000120899 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000120899
Transcript Identifier
ENST00000346049
Gene Type
Coding gene
Location
8 : 27397585-27458509 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P015372
(6 genes in 4 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
protein tyrosine kinase 2 beta

Identifiers

Type Value
pidENSP00000332816
HGNC9612
UniprotQ14289

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0000302
IEA
Genome Projectresponse to reactive oxygen species
GO:0001525
IBA
IEA
Genome Projectangiogenesis
GO:0001556
IEA
Genome Projectoocyte maturation
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001954
IMP
Genome Projectpositive regulation of cell-matrix adhesion
GO:0002040
ISS
IEA
Genome Projectsprouting angiogenesis
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0002315
ISS
IEA
Genome Projectmarginal zone B cell differentiation
GO:0002376
IEA
Genome Projectimmune system process
GO:0002688
IEA
Genome Projectregulation of leukocyte chemotaxis
GO:0006461
TAS
Genome Projectprotein complex assembly
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006950
TAS
Genome Projectresponse to stress
GO:0006968
ISS
IEA
Genome Projectcellular defense response
GO:0006970
IEA
Genome Projectresponse to osmotic stress
GO:0007010
IBA
Genome Projectcytoskeleton organization
GO:0007015
IEA
Genome Projectactin filament organization
GO:0007155
IBA
IEA
Genome Projectcell adhesion
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007166
IMP
Genome Projectcell surface receptor signaling pathway
GO:0007172
TAS, IEA
Genome Projectsignal complex assembly
GO:0007173
IBA
IEA
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007204
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007229
IMP
Genome Projectintegrin-mediated signaling pathway
GO:0008284
IMP
TAS, IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IMP
Genome Projectnegative regulation of cell proliferation
GO:0008360
IMP
Genome Projectregulation of cell shape
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009725
IEA
Genome Projectresponse to hormone
GO:0009749
IEA
Genome Projectresponse to glucose
GO:0010226
IEA
Genome Projectresponse to lithium ion
GO:0010243
IEA
Genome Projectresponse to organonitrogen compound
GO:0010595
IDA
Genome Projectpositive regulation of endothelial cell migration
GO:0010656
IEA
Genome Projectnegative regulation of muscle cell apoptotic process
GO:0010752
IEA
Genome Projectregulation of cGMP-mediated signaling
GO:0010758
ISS
IEA
Genome Projectregulation of macrophage chemotaxis
GO:0010976
IMP
Genome Projectpositive regulation of neuron projection development
GO:0014009
IEA
Genome Projectglial cell proliferation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IBA
Genome Projectcell migration
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030154
IBA
IEA
Genome Projectcell differentiation
GO:0030155
IMP
IEA
Genome Projectregulation of cell adhesion
GO:0030279
IEA
Genome Projectnegative regulation of ossification
GO:0030307
IEA
Genome Projectpositive regulation of cell growth
GO:0030334
IEA
Genome Projectregulation of cell migration
GO:0030335
IMP
IEA
Genome Projectpositive regulation of cell migration
GO:0030500
IEA
Genome Projectregulation of bone mineralization
GO:0030502
ISS
IEA
Genome Projectnegative regulation of bone mineralization
GO:0030826
IEA
Genome Projectregulation of cGMP biosynthetic process
GO:0030838
IMP
Genome Projectpositive regulation of actin filament polymerization
GO:0031175
IEA
Genome Projectneuron projection development
GO:0032960
ISS
IEA
Genome Projectregulation of inositol trisphosphate biosynthetic process
GO:0033209
IMP
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0035235
ISS
IEA
Genome Projectionotropic glutamate receptor signaling pathway
GO:0035902
IEA
Genome Projectresponse to immobilization stress
GO:0038083
IDA
ISS
IEA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042220
IEA
Genome Projectresponse to cocaine
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042976
IMP
IEA
Genome Projectactivation of Janus kinase activity
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043149
IEA
Genome Projectstress fiber assembly
GO:0043267
IDA
Genome Projectnegative regulation of potassium ion transport
GO:0043507
IEA
Genome Projectpositive regulation of JUN kinase activity
GO:0043524
ISS
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043534
IEA
Genome Projectblood vessel endothelial cell migration
GO:0043552
ISS
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045087
IBA
Genome Projectinnate immune response
GO:0045428
IEA
Genome Projectregulation of nitric oxide biosynthetic process
GO:0045453
ISS
IEA
Genome Projectbone resorption
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045638
IMP
Genome Projectnegative regulation of myeloid cell differentiation
GO:0045727
IEA
Genome Projectpositive regulation of translation
GO:0045765
IEA
Genome Projectregulation of angiogenesis
GO:0045766
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045860
IMP
Genome Projectpositive regulation of protein kinase activity
GO:0046330
IMP
Genome Projectpositive regulation of JNK cascade
GO:0046777
TAS
Genome Projectprotein autophosphorylation
GO:0048010
IMP
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048041
IEA
Genome Projectfocal adhesion assembly
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050848
IEA
Genome Projectregulation of calcium-mediated signaling
GO:0051000
IEA
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051279
ISS
IEA
Genome Projectregulation of release of sequestered calcium ion into cytosol
GO:0051591
IEA
Genome Projectresponse to cAMP
GO:0051592
IEA
Genome Projectresponse to calcium ion
GO:0051968
ISS
IEA
Genome Projectpositive regulation of synaptic transmission, glutamatergic
GO:0060291
ISS
IEA
Genome Projectlong-term synaptic potentiation
GO:0070098
ISS
IEA
Genome Projectchemokine-mediated signaling pathway
GO:0070374
IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071300
IMP
Genome Projectcellular response to retinoic acid
GO:0071498
IEA
Genome Projectcellular response to fluid shear stress
GO:0090630
IEA
Genome Projectactivation of GTPase activity
GO:2000058
IDA
Genome Projectregulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000060
IEA
Genome Projectpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000114
ISS
IEA
Genome Projectregulation of establishment of cell polarity
GO:2000249
ISS
IEA
Genome Projectregulation of actin cytoskeleton reorganization
GO:2000310
ISS
IEA
Genome Projectregulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000379
IEA
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2000463
ISS
IEA
Genome Projectpositive regulation of excitatory postsynaptic potential
GO:2000538
ISS
IEA
Genome Projectpositive regulation of B cell chemotaxis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004683
ISS
IEA
Genome Projectcalmodulin-dependent protein kinase activity
GO:0004713
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IDA
TAS, IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0004871
NAS, IEA
Genome Projectsignal transducer activity
GO:0004972
ISS
IEA
Genome ProjectNMDA glutamate receptor activity
GO:0005102
IBA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0043423
IEA
Genome Project3-phosphoinositide-dependent protein kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
TAS, IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005925
IDA
IEA
Genome Projectfocal adhesion
GO:0005938
IEA
Genome Projectcell cortex
GO:0014069
ISS
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0017146
ISS
IEA
Genome ProjectNMDA selective glutamate receptor complex
GO:0030027
IDA
IEA
Genome Projectlamellipodium
GO:0030054
IEA
Genome Projectcell junction
GO:0030424
IEA
Genome Projectaxon
GO:0030425
ISS
IEA
Genome Projectdendrite
GO:0030426
ISS
IEA
Genome Projectgrowth cone
GO:0031234
IBA
IEA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0043025
ISS
IEA
Genome Projectneuronal cell body
GO:0044297
ISS
IEA
Genome Projectcell body
GO:0045121
IEA
Genome Projectmembrane raft
GO:0048471
IDA
IEA
Genome Projectperinuclear region of cytoplasm
GO:0097440
ISS
IEA
Genome Projectapical dendrite

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000299FERM domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR005189Focal adhesion kinase, targeting (FAT) domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR014352FERM/acyl-CoA-binding protein, 3-helical bundle
IPR017441Protein kinase, ATP binding site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR020635Tyrosine-protein kinase, catalytic domain
IPR029071Ubiquitin-related domain
IPR030610Protein-tyrosine kinase 2-beta

No MapMan annotations defined for this gene.