Gene: ENSG00000120156 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000120156
Transcript Identifier
ENST00000380036
Gene Type
Coding gene
Location
9 : 27109591-27229232 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P066255
(2 genes in 2 species)
specific family

Descriptions

gene_descr
TEK tyrosine kinase, endothelial

Identifiers

Type Value
pidENSP00000369375
HGNC11724
UniprotQ02763

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001525
ISS
IEA
Genome Projectangiogenesis
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001934
IDA, IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0001935
ISS
Genome Projectendothelial cell proliferation
GO:0001938
TAS
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001958
IEA
Genome Projectendochondral ossification
GO:0002040
IMP
Genome Projectsprouting angiogenesis
GO:0002741
IEA
Genome Projectpositive regulation of cytokine secretion involved in immune response
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007160
IEA
Genome Projectcell-matrix adhesion
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007169
IDA
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007507
ISS
Genome Projectheart development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010595
IDA, IMP
Genome Projectpositive regulation of endothelial cell migration
GO:0014068
IMP
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016337
IEA
Genome Projectsingle organismal cell-cell adhesion
GO:0016525
IMP
Genome Projectnegative regulation of angiogenesis
GO:0018108
IDA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030097
IEA
Genome Projecthemopoiesis
GO:0030334
IEA
Genome Projectregulation of cell migration
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0032878
IMP
Genome Projectregulation of establishment or maintenance of cell polarity
GO:0033138
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034446
IMP
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0042307
IEA
Genome Projectpositive regulation of protein import into nucleus
GO:0043066
TAS, IEA
Genome Projectnegative regulation of apoptotic process
GO:0043114
TAS
Genome Projectregulation of vascular permeability
GO:0043434
IEA
Genome Projectresponse to peptide hormone
GO:0043552
IMP
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045765
IEA
Genome Projectregulation of angiogenesis
GO:0045766
IDA, IMP
Genome Projectpositive regulation of angiogenesis
GO:0045785
IEA
Genome Projectpositive regulation of cell adhesion
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0048014
IDA
Genome ProjectTie signaling pathway
GO:0050728
TAS
Genome Projectnegative regulation of inflammatory response
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0051259
IDA
Genome Projectprotein oligomerization
GO:0051591
IEA
Genome Projectresponse to cAMP
GO:0051894
IMP
Genome Projectpositive regulation of focal adhesion assembly
GO:0051897
IDA, IMP
Genome Projectpositive regulation of protein kinase B signaling
GO:0060216
TAS
Genome Projectdefinitive hemopoiesis
GO:0060347
ISS
Genome Projectheart trabecula formation
GO:0070374
IDA, IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:1901222
IEA
Genome Projectregulation of NIK/NF-kappaB signaling
GO:1902533
IMP
Genome Projectpositive regulation of intracellular signal transduction
GO:2000251
IMP
Genome Projectpositive regulation of actin cytoskeleton reorganization
GO:2000351
TAS
Genome Projectregulation of endothelial cell apoptotic process
GO:2000352
ISS
Genome Projectnegative regulation of endothelial cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
TAS, IEA
Genome Projectprotein kinase activity
GO:0004713
IDA
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004872
TAS, IEA
Genome Projectreceptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019838
IEA
Genome Projectgrowth factor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
TAS, IEA
Genome Projectintegral component of plasma membrane
GO:0005902
IDA
Genome Projectmicrovillus
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0005925
IEA
Genome Projectfocal adhesion
GO:0009925
IDA
Genome Projectbasal plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
IDA
Genome Projectbasolateral plasma membrane
GO:0016324
IDA
Genome Projectapical plasma membrane
GO:0030054
IEA
Genome Projectcell junction
GO:0045121
IDA
Genome Projectmembrane raft
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0001725
IDA
Genome Projectstress fiber
GO:0005884
IDA
Genome Projectactin filament

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000742EGF-like domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR003961Fibronectin type III
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013032EGF-like, conserved site
IPR013783Immunoglobulin-like fold
IPR017441Protein kinase, ATP binding site
IPR018941Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.