Gene: ENSG00000118503 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000118503
Transcript Identifier
ENST00000237289
Gene Type
Coding gene
Location
6 : 137871228-137881319 : positive

Family Information

Homologous gene family
HOM03P007673
(11 genes in 7 species)
specific family

Descriptions

gene_descr
tumor necrosis factor, alpha-induced protein 3

Identifiers

Type Value
pidENSP00000237289
HGNC11896
UniprotP21580

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001922
ISS
IEA
Genome ProjectB-1 B cell homeostasis
GO:0002237
IDA
Genome Projectresponse to molecule of bacterial origin
GO:0002634
ISS
IEA
Genome Projectregulation of germinal center formation
GO:0002677
IEA
Genome Projectnegative regulation of chronic inflammatory response
GO:0006508
IEA
Genome Projectproteolysis
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006954
IEA
Genome Projectinflammatory response
GO:0008152
IEA
Genome Projectmetabolic process
GO:0016579
TAS, IEA
Genome Projectprotein deubiquitination
GO:0031397
IDA
Genome Projectnegative regulation of protein ubiquitination
GO:0032088
IDA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032480
TAS
Genome Projectnegative regulation of type I interferon production
GO:0032495
IEA
Genome Projectresponse to muramyl dipeptide
GO:0032691
IEA
Genome Projectnegative regulation of interleukin-1 beta production
GO:0032703
IMP
Genome Projectnegative regulation of interleukin-2 production
GO:0032715
ISS
IEA
Genome Projectnegative regulation of interleukin-6 production
GO:0032720
ISS
IEA
Genome Projectnegative regulation of tumor necrosis factor production
GO:0034136
NAS
Genome Projectnegative regulation of toll-like receptor 2 signaling pathway
GO:0034140
IDA
Genome Projectnegative regulation of toll-like receptor 3 signaling pathway
GO:0034144
NAS
Genome Projectnegative regulation of toll-like receptor 4 signaling pathway
GO:0034148
IEA
Genome Projectnegative regulation of toll-like receptor 5 signaling pathway
GO:0035871
IDA
Genome Projectprotein K11-linked deubiquitination
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043124
IDA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045732
IDA
Genome Projectpositive regulation of protein catabolic process
GO:0045736
IEA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045779
NAS
Genome Projectnegative regulation of bone resorption
GO:0045824
ISS
IEA
Genome Projectnegative regulation of innate immune response
GO:0048662
IDA
Genome Projectnegative regulation of smooth muscle cell proliferation
GO:0050691
NAS
Genome Projectregulation of defense response to virus by host
GO:0050727
IBA
Genome Projectregulation of inflammatory response
GO:0050728
ISS
IEA
Genome Projectnegative regulation of inflammatory response
GO:0050869
ISS
IEA
Genome Projectnegative regulation of B cell activation
GO:0051259
NAS
Genome Projectprotein oligomerization
GO:0060548
IEA
Genome Projectnegative regulation of cell death
GO:0061043
NAS
Genome Projectregulation of vascular wound healing
GO:0070301
ISS
IEA
Genome Projectcellular response to hydrogen peroxide
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070429
IEA
Genome Projectnegative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433
IEA
Genome Projectnegative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070536
IDA
Genome Projectprotein K63-linked deubiquitination
GO:0070936
IDA
Genome Projectprotein K48-linked ubiquitination
GO:0071108
IDA
Genome Projectprotein K48-linked deubiquitination
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071947
IBA
Genome Projectprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072573
IMP
Genome Projecttolerance induction to lipopolysaccharide
GO:0072666
IEA
Genome Projectestablishment of protein localization to vacuole
GO:0090291
NAS
Genome Projectnegative regulation of osteoclast proliferation
GO:1902042
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903364
IEA
Genome Projectpositive regulation of cellular protein catabolic process
GO:2000347
IEA
Genome Projectpositive regulation of hepatocyte proliferation
GO:2000349
IMP
Genome Projectnegative regulation of CD40 signaling pathway
GO:2000352
IDA
Genome Projectnegative regulation of endothelial cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
Genome Projectprotease binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003824
IEA
Genome Projectcatalytic activity
GO:0004842
IDA
Genome Projectubiquitin-protein transferase activity
GO:0004843
IDA
TAS
Genome Projectubiquitin-specific protease activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008234
IEA
Genome Projectcysteine-type peptidase activity
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016874
IEA
Genome Projectligase activity
GO:0019900
IEA
Genome Projectkinase binding
GO:0043130
IPI
Genome Projectubiquitin binding
GO:0043621
IDA
Genome Projectprotein self-association
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0070530
IBA
Genome ProjectK63-linked polyubiquitin binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005764
IEA
Genome Projectlysosome
GO:0005813
IDA
Genome Projectcentrosome
GO:0005829
TAS
Genome Projectcytosol
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002653Zinc finger, A20-type
IPR003323OTU domain

No MapMan annotations defined for this gene.