Gene: ENSG00000118137 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000118137
Transcript Identifier
ENST00000236850
Gene Type
Coding gene
Location
11 : 116835808-116837387 : negative

Family Information

Homologous gene family
HOM03P027973
(3 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
apolipoprotein A-I

Identifiers

Type Value
pidENSP00000236850
HGNC600
UniprotP02647
UniprotA0A024R3E3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001932
IEA
Genome Projectregulation of protein phosphorylation
GO:0001935
IEA
Genome Projectendothelial cell proliferation
GO:0006644
IEA
Genome Projectphospholipid metabolic process
GO:0006695
IBA
IEA
Genome Projectcholesterol biosynthetic process
GO:0006810
IEA
Genome Projecttransport
GO:0006869
IEA
Genome Projectlipid transport
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0008211
IEA
Genome Projectglucocorticoid metabolic process
GO:0014012
IEA
Genome Projectperipheral nervous system axon regeneration
GO:0015914
IEA
Genome Projectphospholipid transport
GO:0019915
IEA
Genome Projectlipid storage
GO:0030300
IBA
IEA
Genome Projectregulation of intestinal cholesterol absorption
GO:0030301
IDA
IEA
Genome Projectcholesterol transport
GO:0030325
IEA
Genome Projectadrenal gland development
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0042157
IBA
TAS, IEA
Genome Projectlipoprotein metabolic process
GO:0042158
IEA
Genome Projectlipoprotein biosynthetic process
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043534
IEA
Genome Projectblood vessel endothelial cell migration
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0051346
IEA
Genome Projectnegative regulation of hydrolase activity
GO:0051347
IEA
Genome Projectpositive regulation of transferase activity
GO:0060192
IEA
Genome Projectnegative regulation of lipase activity
GO:0001523
TAS
Genome Projectretinoid metabolic process
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0002740
IDA
Genome Projectnegative regulation of cytokine secretion involved in immune response
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006656
IDA
Genome Projectphosphatidylcholine biosynthetic process
GO:0006898
TAS
Genome Projectreceptor-mediated endocytosis
GO:0007186
IDA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007229
IDA
Genome Projectintegrin-mediated signaling pathway
GO:0007596
TAS
Genome Projectblood coagulation
GO:0007603
TAS
Genome Projectphototransduction, visible light
GO:0008202
IEA
Genome Projectsteroid metabolic process
GO:0008203
IMP
IEA
Genome Projectcholesterol metabolic process
GO:0010804
IDA
Genome Projectnegative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010873
IDA
Genome Projectpositive regulation of cholesterol esterification
GO:0010898
IBA
Genome Projectpositive regulation of triglyceride catabolic process
GO:0010903
IDA
Genome Projectnegative regulation of very-low-density lipoprotein particle remodeling
GO:0018158
IDA
Genome Projectprotein oxidation
GO:0018206
IDA
Genome Projectpeptidyl-methionine modification
GO:0019433
IBA
Genome Projecttriglyceride catabolic process
GO:0030168
TAS
Genome Projectplatelet activation
GO:0031102
IBA
Genome Projectneuron projection regeneration
GO:0032489
IDA
Genome Projectregulation of Cdc42 protein signal transduction
GO:0033344
IDA, IMP
Genome Projectcholesterol efflux
GO:0033700
IDA
Genome Projectphospholipid efflux
GO:0034115
IDA
Genome Projectnegative regulation of heterotypic cell-cell adhesion
GO:0034372
IBA
Genome Projectvery-low-density lipoprotein particle remodeling
GO:0034375
IDA
IC
Genome Projecthigh-density lipoprotein particle remodeling
GO:0034380
IDA
Genome Projecthigh-density lipoprotein particle assembly
GO:0034384
IC
Genome Projecthigh-density lipoprotein particle clearance
GO:0035025
IDA
Genome Projectpositive regulation of Rho protein signal transduction
GO:0042632
IDA, IMP
Genome Projectcholesterol homeostasis
GO:0043691
IMP
Genome Projectreverse cholesterol transport
GO:0044255
TAS
Genome Projectcellular lipid metabolic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045723
IBA
Genome Projectpositive regulation of fatty acid biosynthetic process
GO:0050713
IDA
Genome Projectnegative regulation of interleukin-1 beta secretion
GO:0050728
IDA
Genome Projectnegative regulation of inflammatory response
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0050919
IDA
Genome Projectnegative chemotaxis
GO:0051006
IBA
Genome Projectpositive regulation of lipoprotein lipase activity
GO:0051180
IMP
Genome Projectvitamin transport
GO:0051345
IDA
Genome Projectpositive regulation of hydrolase activity
GO:0051496
IDA
Genome Projectpositive regulation of stress fiber assembly
GO:0055085
TAS
Genome Projecttransmembrane transport
GO:0055091
IDA
Genome Projectphospholipid homeostasis
GO:0060354
IDA
Genome Projectnegative regulation of cell adhesion molecule production
GO:0060761
IDA
Genome Projectnegative regulation of response to cytokine stimulus
GO:0070328
IDA
Genome Projecttriglyceride homeostasis
GO:0070508
IMP
Genome Projectcholesterol import
GO:1900026
IDA
Genome Projectpositive regulation of substrate adhesion-dependent cell spreading
GO:0007179
IDA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0070371
IDA
Genome ProjectERK1 and ERK2 cascade

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005319
IEA
Genome Projectlipid transporter activity
GO:0005548
IEA
Genome Projectphospholipid transporter activity
GO:0008035
IEA
Genome Projecthigh-density lipoprotein particle binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0017127
IDA, IMP
IEA
Genome Projectcholesterol transporter activity
GO:0055102
IEA
Genome Projectlipase inhibitor activity
GO:0071813
IEA
Genome Projectlipoprotein particle binding
GO:0001540
IDA
Genome Projectbeta-amyloid binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005543
IDA
Genome Projectphospholipid binding
GO:0015485
IDA
Genome Projectcholesterol binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0031210
IBA
Genome Projectphosphatidylcholine binding
GO:0034190
IPI
Genome Projectapolipoprotein receptor binding
GO:0034191
IPI
Genome Projectapolipoprotein A-I receptor binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0045499
IDA
Genome Projectchemorepellent activity
GO:0060228
IDA
Genome Projectphosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653
IPI
Genome Projecthigh-density lipoprotein particle receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
ISS
IEA
Genome Projectextracellular space
GO:0005634
IEA
Genome Projectnucleus
GO:0009986
IEA
Genome Projectcell surface
GO:0034365
IEA
Genome Projectdiscoidal high-density lipoprotein particle
GO:0005769
TAS
Genome Projectearly endosome
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
TAS
Genome Projectplasma membrane
GO:0030139
IDA
Genome Projectendocytic vesicle
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0034361
IDA
Genome Projectvery-low-density lipoprotein particle
GO:0034364
IDA
IEA
Genome Projecthigh-density lipoprotein particle
GO:0034366
IDA
Genome Projectspherical high-density lipoprotein particle
GO:0034774
TAS
Genome Projectsecretory granule lumen
GO:0042627
IBA
Genome Projectchylomicron
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0071682
TAS
Genome Projectendocytic vesicle lumen
GO:0072562
IDA
Genome Projectblood microparticle
GO:1903561
IDA
Genome Projectextracellular vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000074Apolipoprotein A/E

No MapMan annotations defined for this gene.