Gene: ENSG00000116288 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000116288
Transcript Identifier
ENST00000377488
Gene Type
Coding gene
Location
1 : 7962786-7985054 : positive

Family Information

Homologous gene family
HOM03P001356
(52 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P000828
(43 genes in 37 species)
specific family

Descriptions

gene_descr
parkinson protein 7

Identifiers

Type Value
pidENSP00000366708
HGNC16369
UniprotQ99497
UniprotV9HWC2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001933
IGI
Genome Projectnegative regulation of protein phosphorylation
GO:0001963
IEA
Genome Projectsynaptic transmission, dopaminergic
GO:0006469
IGI
Genome Projectnegative regulation of protein kinase activity
GO:0006508
IEA
Genome Projectproteolysis
GO:0006517
IDA
Genome Projectprotein deglycosylation
GO:0006914
IEA
Genome Projectautophagy
GO:0006954
IEA
Genome Projectinflammatory response
GO:0007005
ISS
IEA
Genome Projectmitochondrion organization
GO:0007265
TAS
Genome ProjectRas protein signal transduction
GO:0007338
IEA
Genome Projectsingle fertilization
GO:0008344
IEA
Genome Projectadult locomotory behavior
GO:0010273
IMP
Genome Projectdetoxification of copper ion
GO:0010628
TAS, IEA
Genome Projectpositive regulation of gene expression
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0018323
IEA
Genome Projectenzyme active site formation via L-cysteine sulfinic acid
GO:0019243
IDA
Genome Projectmethylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
GO:0019249
IDA
Genome Projectlactate biosynthetic process
GO:0031397
IDA
Genome Projectnegative regulation of protein ubiquitination
GO:0032091
IDA, IMP, IGI
Genome Projectnegative regulation of protein binding
GO:0032148
IC
Genome Projectactivation of protein kinase B activity
GO:0032435
IDA
Genome Projectnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0033138
IMP
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033234
IDA
Genome Projectnegative regulation of protein sumoylation
GO:0034599
IDA, IMP
Genome Projectcellular response to oxidative stress
GO:0034614
IEA
Genome Projectcellular response to reactive oxygen species
GO:0036471
IDA
Genome Projectcellular response to glyoxal
GO:0042177
IEA
Genome Projectnegative regulation of protein catabolic process
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042743
IDA
Genome Projecthydrogen peroxide metabolic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043523
IDA
Genome Projectregulation of neuron apoptotic process
GO:0043524
IDA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045944
IDA, IMP, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046295
IDA
Genome Projectglycolate biosynthetic process
GO:0046826
IGI
Genome Projectnegative regulation of protein export from nucleus
GO:0050727
ISS
IEA
Genome Projectregulation of inflammatory response
GO:0050787
IMP
Genome Projectdetoxification of mercury ion
GO:0050821
IDA, IMP
Genome Projectprotein stabilization
GO:0051091
IMP
TAS
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444
IDA
Genome Projectnegative regulation of ubiquitin-protein transferase activity
GO:0051583
IEA
Genome Projectdopamine uptake involved in synaptic transmission
GO:0051881
IMP
Genome Projectregulation of mitochondrial membrane potential
GO:0051897
IC
Genome Projectpositive regulation of protein kinase B signaling
GO:0051899
IEA
Genome Projectmembrane depolarization
GO:0060081
IEA
Genome Projectmembrane hyperpolarization
GO:0060548
IDA
Genome Projectnegative regulation of cell death
GO:0060765
IDA
Genome Projectregulation of androgen receptor signaling pathway
GO:0070301
IDA
Genome Projectcellular response to hydrogen peroxide
GO:0090073
IDA
Genome Projectpositive regulation of protein homodimerization activity
GO:1900182
IDA, IMP
Genome Projectpositive regulation of protein localization to nucleus
GO:1901215
IDA
Genome Projectnegative regulation of neuron death
GO:1901671
IDA
Genome Projectpositive regulation of superoxide dismutase activity
GO:1901984
IDA
Genome Projectnegative regulation of protein acetylation
GO:1902177
IEA
Genome Projectpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902236
IGI
Genome Projectnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902903
TAS
Genome Projectregulation of fibril organization
GO:1902958
IMP
Genome Projectpositive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903073
IC
Genome Projectnegative regulation of death-inducing signaling complex assembly
GO:1903094
IDA
Genome Projectnegative regulation of protein K48-linked deubiquitination
GO:1903122
IMP
Genome Projectnegative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903168
IDA
Genome Projectpositive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178
IDA
Genome Projectpositive regulation of tyrosine 3-monooxygenase activity
GO:1903181
IDA
IC
Genome Projectpositive regulation of dopamine biosynthetic process
GO:1903190
IDA
Genome Projectglyoxal catabolic process
GO:1903197
IMP
Genome Projectpositive regulation of L-dopa biosynthetic process
GO:1903200
IDA
Genome Projectpositive regulation of L-dopa decarboxylase activity
GO:1903202
IDA
Genome Projectnegative regulation of oxidative stress-induced cell death
GO:1903204
IEA
Genome Projectnegative regulation of oxidative stress-induced neuron death
GO:1903206
IMP
Genome Projectnegative regulation of hydrogen peroxide-induced cell death
GO:1903208
IDA
Genome Projectnegative regulation of hydrogen peroxide-induced neuron death
GO:1903377
IDA
Genome Projectnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903384
IGI
Genome Projectnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903428
IEA
Genome Projectpositive regulation of reactive oxygen species biosynthetic process
GO:1903599
NAS
Genome Projectpositive regulation of mitophagy
GO:2000157
IDA
Genome Projectnegative regulation of ubiquitin-specific protease activity
GO:2000277
IEA
Genome Projectpositive regulation of oxidative phosphorylation uncoupler activity
GO:2000679
IMP
Genome Projectpositive regulation of transcription regulatory region DNA binding
GO:2000825
IMP
Genome Projectpositive regulation of androgen receptor activity
GO:2001237
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2001268
IMP
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045560
IMP
Genome Projectregulation of TRAIL receptor biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003713
IGI
TAS
Genome Projecttranscription coactivator activity
GO:0003723
IEA
Genome ProjectRNA binding
GO:0003729
IDA
Genome ProjectmRNA binding
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005507
IDA
Genome Projectcopper ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008233
IDA
IEA
Genome Projectpeptidase activity
GO:0016532
IDA
Genome Projectsuperoxide dismutase copper chaperone activity
GO:0016684
IDA
Genome Projectoxidoreductase activity, acting on peroxide as acceptor
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0019172
IDA
Genome Projectglyoxalase III activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019900
IPI
Genome Projectkinase binding
GO:0019955
IPI
Genome Projectcytokine binding
GO:0036470
IDA
Genome Projecttyrosine 3-monooxygenase activator activity
GO:0036478
IDA
Genome ProjectL-dopa decarboxylase activator activity
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0044388
IPI
Genome Projectsmall protein activating enzyme binding
GO:0044390
IPI
Genome Projectubiquitin-like protein conjugating enzyme binding
GO:0045340
IDA
Genome Projectmercury ion binding
GO:0050681
IPI
Genome Projectandrogen receptor binding
GO:0051920
IEA
Genome Projectperoxiredoxin activity
GO:0070491
IPI
Genome Projectrepressing transcription factor binding
GO:0097110
IPI
Genome Projectscaffold protein binding
GO:1903135
IDA
Genome Projectcupric ion binding
GO:1903136
IDA
Genome Projectcuprous ion binding
GO:1990381
IPI
Genome Projectubiquitin-specific protease binding
GO:1990422
IDA
Genome Projectglyoxalase (glycolic acid-forming) activity
GO:0001047
IC
Genome Projectcore promoter binding
GO:0003690
IDA
Genome Projectdouble-stranded DNA binding
GO:0003697
IDA
Genome Projectsingle-stranded DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000785
IDA
Genome Projectchromatin
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA, IMP
IEA
Genome Projectmitochondrion
GO:0005758
IEA
Genome Projectmitochondrial intermembrane space
GO:0005759
IEA
Genome Projectmitochondrial matrix
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005829
IDA, IMP
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016605
IDA
Genome ProjectPML body
GO:0030424
ISS
Genome Projectaxon
GO:0043005
IEA
Genome Projectneuron projection
GO:0044297
IEA
Genome Projectcell body
GO:0045121
IEA
Genome Projectmembrane raft
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0005747
IDA
Genome Projectmitochondrial respiratory chain complex I

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002818DJ-1/PfpI
IPR006287DJ-1
IPR029062Class I glutamine amidotransferase-like

No MapMan annotations defined for this gene.