Gene: ENSG00000116285 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000116285
Transcript Identifier
ENST00000377482
Gene Type
Coding gene
Location
1 : 8013210-8015619 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family

Descriptions

gene_descr
ERBB receptor feedback inhibitor 1

Identifiers

Type Value
pidENSP00000366702
HGNC18185
UniprotQ9UJM3
UniprotI6S2Y9

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032691
IEA
Genome Projectnegative regulation of interleukin-1 beta production
GO:0032869
IEA
Genome Projectcellular response to insulin stimulus
GO:0032966
IEA
Genome Projectnegative regulation of collagen biosynthetic process
GO:0036120
IEA
Genome Projectcellular response to platelet-derived growth factor stimulus
GO:0042059
IEA
Genome Projectnegative regulation of epidermal growth factor receptor signaling pathway
GO:0042536
IEA
Genome Projectnegative regulation of tumor necrosis factor biosynthetic process
GO:0043589
ISS
IEA
Genome Projectskin morphogenesis
GO:0045616
ISS, IBA
IEA
Genome Projectregulation of keratinocyte differentiation
GO:0048286
ISS
IEA
Genome Projectlung alveolus development
GO:0060426
ISS
IEA
Genome Projectlung vasculature development
GO:0060428
ISS
IEA
Genome Projectlung epithelium development
GO:0061469
IEA
Genome Projectregulation of type B pancreatic cell proliferation
GO:0070373
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0071364
IEA
Genome Projectcellular response to epidermal growth factor stimulus
GO:0071474
IEA
Genome Projectcellular hyperosmotic response
GO:0071549
IEA
Genome Projectcellular response to dexamethasone stimulus
GO:1903243
IEA
Genome Projectnegative regulation of cardiac muscle hypertrophy in response to stress
GO:0006950
TAS
Genome Projectresponse to stress
GO:0007175
IDA
ISS
Genome Projectnegative regulation of epidermal growth factor-activated receptor activity
GO:0031953
IDA
Genome Projectnegative regulation of protein autophosphorylation
GO:0043547
TAS
Genome Projectpositive regulation of GTPase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0017124
IEA
Genome ProjectSH3 domain binding
GO:0019900
IEA
Genome Projectkinase binding
GO:0031267
IEA
Genome Projectsmall GTPase binding
GO:0005096
TAS
Genome ProjectGTPase activator activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019901
IPI
Genome Projectprotein kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
ISS
TAS, IEA
Genome Projectcytoplasm
GO:0005829
IEA
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0031234
ISS, IBA
IEA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0005634
IEA
Genome Projectnucleus
GO:0016020
IEA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR015116Cdc42 binding domain-like
IPR021619Mig-6 domain

No MapMan annotations defined for this gene.