Gene: ENSG00000116106 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000116106
Transcript Identifier
ENST00000409938
Gene Type
Coding gene
Location
2 : 221426028-221572248 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P003318
(24 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
EPH receptor A4

Identifiers

Type Value
pidENSP00000386829
HGNC3388
UniprotP54764
UniprotA0A024R452

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411
TAS, IEA
Genome Projectaxon guidance
GO:0007628
IEA
Genome Projectadult walking behavior
GO:0008045
ISS
IEA
Genome Projectmotor neuron axon guidance
GO:0008347
IEA
Genome Projectglial cell migration
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0021957
ISS
IEA
Genome Projectcorticospinal tract morphogenesis
GO:0043087
ISS
IEA
Genome Projectregulation of GTPase activity
GO:0043507
IEA
Genome Projectpositive regulation of JUN kinase activity
GO:0048013
TAS, IEA
Genome Projectephrin receptor signaling pathway
GO:0048681
ISS
IEA
Genome Projectnegative regulation of axon regeneration
GO:0048710
ISS
IEA
Genome Projectregulation of astrocyte differentiation
GO:0050770
ISS
IEA
Genome Projectregulation of axonogenesis
GO:0050775
IEA
Genome Projectpositive regulation of dendrite morphogenesis
GO:0061001
ISS
IEA
Genome Projectregulation of dendritic spine morphogenesis
GO:0072178
IEA
Genome Projectnephric duct morphogenesis
GO:0097155
ISS
IEA
Genome Projectfasciculation of sensory neuron axon
GO:0097156
ISS
IEA
Genome Projectfasciculation of motor neuron axon
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007399
IEA
Genome Projectnervous system development
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:2001108
IDA
Genome Projectpositive regulation of Rho guanyl-nucleotide exchange factor activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005003
IEA
Genome Projectephrin receptor activity
GO:0005004
ISS
IEA
Genome ProjectGPI-linked ephrin receptor activity
GO:0005005
ISS
IEA
Genome Projecttransmembrane-ephrin receptor activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0042802
IEA
Genome Projectidentical protein binding
GO:0046875
IEA
Genome Projectephrin receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0042731
IPI
Genome ProjectPH domain binding
GO:0097161
IDA
Genome ProjectDH domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISS
IEA
Genome Projectcytoplasm
GO:0005741
IEA
Genome Projectmitochondrial outer membrane
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005887
ISS
IEA
Genome Projectintegral component of plasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030175
IEA
Genome Projectfilopodium
GO:0030424
ISS
IEA
Genome Projectaxon
GO:0030425
ISS
IEA
Genome Projectdendrite
GO:0031594
IEA
Genome Projectneuromuscular junction
GO:0031901
ISS
IEA
Genome Projectearly endosome membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0043197
IEA
Genome Projectdendritic spine
GO:0043204
IEA
Genome Projectperikaryon
GO:0043679
IEA
Genome Projectaxon terminus
GO:0044295
IEA
Genome Projectaxonal growth cone
GO:0044297
IEA
Genome Projectcell body
GO:0005768
IEA
Genome Projectendosome
GO:0005769
IEA
Genome Projectearly endosome
GO:0030054
IEA
Genome Projectcell junction
GO:0045202
IEA
Genome Projectsynapse
GO:0045211
IEA
Genome Projectpostsynaptic membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001090Ephrin receptor ligand binding domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001426Tyrosine-protein kinase, receptor class V, conserved site
IPR001660Sterile alpha motif domain
IPR003961Fibronectin type III
IPR008266Tyrosine-protein kinase, active site
IPR008979Galactose-binding domain-like
IPR011009Protein kinase-like domain
IPR013761Sterile alpha motif/pointed domain
IPR013783Immunoglobulin-like fold
IPR016257Ephrin receptor type-A /type-B
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR027936Ephrin receptor, transmembrane domain

No MapMan annotations defined for this gene.