Gene: ENSG00000115415 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000115415
Transcript Identifier
ENST00000409465
Gene Type
Coding gene
Location
2 : 190970703-191010003 : negative

Family Information

Homologous gene family
HOM03P007485
(11 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P018601
(5 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
signal transducer and activator of transcription 1, 91kDa

Identifiers

Type Value
pidENSP00000386244
HGNC11362
UniprotP42224

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001937
IMP
Genome Projectnegative regulation of endothelial cell proliferation
GO:0002053
ISS
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0003340
ISS
Genome Projectnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006915
ISS
Genome Projectapoptotic process
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007259
IDA
Genome ProjectJAK-STAT cascade
GO:0008015
ISS
Genome Projectblood circulation
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0016032
IEA
Genome Projectviral process
GO:0016525
IMP
Genome Projectnegative regulation of angiogenesis
GO:0019221
TAS, IEA
Genome Projectcytokine-mediated signaling pathway
GO:0031663
IEA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0033209
IDA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034097
ISS
Genome Projectresponse to cytokine
GO:0034240
IEA
Genome Projectnegative regulation of macrophage fusion
GO:0035456
IMP
Genome Projectresponse to interferon-beta
GO:0035458
IMP
Genome Projectcellular response to interferon-beta
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0043124
IMP
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330
IEA
Genome Projectresponse to exogenous dsRNA
GO:0043434
ISS
Genome Projectresponse to peptide hormone
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046725
IMP
Genome Projectnegative regulation by virus of viral protein levels in host cell
GO:0048661
ISS
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0051591
ISS
Genome Projectresponse to cAMP
GO:0051607
IEA
Genome Projectdefense response to virus
GO:0060333
IDA
ISS
TAS
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060334
TAS
Genome Projectregulation of interferon-gamma-mediated signaling pathway
GO:0060337
ISS
TAS
Genome Projecttype I interferon signaling pathway
GO:0060338
TAS
Genome Projectregulation of type I interferon-mediated signaling pathway
GO:0060397
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway
GO:0061326
IMP
Genome Projectrenal tubule development
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0072136
ISS
Genome Projectmetanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162
ISS
Genome Projectmetanephric mesenchymal cell differentiation
GO:0072308
ISS
Genome Projectnegative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0006357
IDA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0043542
IMP
Genome Projectendothelial cell migration

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000978
IDA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979
IDA
Genome ProjectRNA polymerase II core promoter sequence-specific DNA binding
GO:0000983
IDA
Genome Projecttranscription factor activity, RNA polymerase II core promoter sequence-specific
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003690
IDA
Genome Projectdouble-stranded DNA binding
GO:0003700
IDA
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0005164
IPI
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005730
IDA
Genome Projectnucleolus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0030424
ISS
Genome Projectaxon
GO:0030425
ISS
Genome Projectdendrite
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000980SH2 domain
IPR001217Transcription factor STAT
IPR008967p53-like transcription factor, DNA-binding
IPR011992EF-hand domain pair
IPR012345STAT transcription factor, DNA-binding, subdomain
IPR013799STAT transcription factor, protein interaction
IPR013800STAT transcription factor, all-alpha domain
IPR013801STAT transcription factor, DNA-binding
IPR015988STAT transcription factor, coiled coil
IPR022752Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal

No MapMan annotations defined for this gene.