Gene: ENSG00000115233 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000115233
Transcript Identifier
ENST00000409682
Gene Type
Coding gene
Location
2 : 161318826-161411400 : positive

Family Information

Homologous gene family
HOM03P000513
(95 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000695
(45 genes in 39 species)
specific family

Descriptions

gene_descr
proteasome (prosome, macropain) 26S subunit, non- ATPase, 14

Identifiers

Type Value
pidENSP00000386541
HGNC16889
UniprotO00487

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000082
TAS
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000209
TAS
Genome Projectprotein polyubiquitination
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0000724
IMP
Genome Projectdouble-strand break repair via homologous recombination
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002474
TAS
Genome Projectantigen processing and presentation of peptide antigen via MHC class I
GO:0002479
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006281
IEA
Genome ProjectDNA repair
GO:0006303
IMP
Genome Projectdouble-strand break repair via nonhomologous end joining
GO:0006508
IEA
Genome Projectproteolysis
GO:0006511
TAS
Genome Projectubiquitin-dependent protein catabolic process
GO:0006521
TAS
Genome Projectregulation of cellular amino acid metabolic process
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006977
TAS
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467
TAS
Genome Projectgene expression
GO:0010950
IMP
Genome Projectpositive regulation of endopeptidase activity
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0016032
TAS
Genome Projectviral process
GO:0031145
TAS
Genome Projectanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641
TAS
Genome Projectcellular nitrogen compound metabolic process
GO:0042590
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0051436
TAS
Genome Projectnegative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437
TAS
Genome Projectpositive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0051439
TAS
Genome Projectregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061136
IMP
Genome Projectregulation of proteasomal protein catabolic process
GO:0070536
IMP
TAS
Genome Projectprotein K63-linked deubiquitination
GO:0090090
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090263
TAS
Genome Projectpositive regulation of canonical Wnt signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008237
TAS, IEA
Genome Projectmetallopeptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0061133
IMP
Genome Projectendopeptidase activator activity
GO:0070628
IDA
Genome Projectproteasome binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000502
IDA
TAS, IEA
Genome Projectproteasome complex
GO:0005634
IDA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0008541
IMP
Genome Projectproteasome regulatory particle, lid subcomplex
GO:0022624
ISS
IEA
Genome Projectproteasome accessory complex
GO:0031597
IEA
Genome Projectcytosolic proteasome complex
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000555JAB1/MPN/MOV34 metalloenzyme domain
IPR024969Rpn11/EIF3F, C-terminal

No MapMan annotations defined for this gene.