Gene: ENSG00000114251 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000114251
Transcript Identifier
ENST00000264634
Gene Type
Coding gene
Location
3 : 55470092-55486985 : negative

Family Information

Homologous gene family
HOM03P001537
(49 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P024443
(4 genes in 3 species)
specific family

Descriptions

gene_descr
wingless-type MMTV integration site family, member 5A

Identifiers

Type Value
pidENSP00000264634
HGNC12784
UniprotP41221

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
IDA
Genome Projectactivation of MAPK activity
GO:0001667
IEA
Genome Projectameboidal-type cell migration
GO:0001736
IEA
Genome Projectestablishment of planar polarity
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0001819
IEA
Genome Projectpositive regulation of cytokine production
GO:0001837
IEP
Genome Projectepithelial to mesenchymal transition
GO:0001843
IEA
Genome Projectneural tube closure
GO:0001934
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
IMP
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001947
IEA
Genome Projectheart looping
GO:0002009
IEA
Genome Projectmorphogenesis of an epithelium
GO:0002053
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0002088
ISS
Genome Projectlens development in camera-type eye
GO:0002741
IMP
Genome Projectpositive regulation of cytokine secretion involved in immune response
GO:0003323
IEA
Genome Projecttype B pancreatic cell development
GO:0003344
IEA
Genome Projectpericardium morphogenesis
GO:0003401
IEA
Genome Projectaxis elongation
GO:0003408
ISS
Genome Projectoptic cup formation involved in camera-type eye development
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007223
IDA, IMP
Genome ProjectWnt signaling pathway, calcium modulating pathway
GO:0007254
IEA
Genome ProjectJNK cascade
GO:0007257
IDA, IMP
Genome Projectactivation of JUN kinase activity
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007368
IEA
Genome Projectdetermination of left/right symmetry
GO:0007411
ISS
IEA
Genome Projectaxon guidance
GO:0007442
IEA
Genome Projecthindgut morphogenesis
GO:0007494
IEA
Genome Projectmidgut development
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008584
IEP
IEA
Genome Projectmale gonad development
GO:0008595
IEA
Genome Projectanterior/posterior axis specification, embryo
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0010033
IEP
Genome Projectresponse to organic substance
GO:0010595
IMP
Genome Projectpositive regulation of endothelial cell migration
GO:0010800
IEA
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0010820
IMP
Genome Projectpositive regulation of T cell chemotaxis
GO:0010976
ISS
IEA
Genome Projectpositive regulation of neuron projection development
GO:0016055
IDA
IEA
Genome ProjectWnt signaling pathway
GO:0016477
IEA
Genome Projectcell migration
GO:0021891
ISS
IEA
Genome Projectolfactory bulb interneuron development
GO:0021915
IEA
Genome Projectneural tube development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030182
ISS, IBA
Genome Projectneuron differentiation
GO:0030216
IEP
Genome Projectkeratinocyte differentiation
GO:0030324
IEA
Genome Projectlung development
GO:0030326
IEA
Genome Projectembryonic limb morphogenesis
GO:0030514
IEA
Genome Projectnegative regulation of BMP signaling pathway
GO:0030825
IDA
Genome Projectpositive regulation of cGMP metabolic process
GO:0030901
IEA
Genome Projectmidbrain development
GO:0032148
IDA
Genome Projectactivation of protein kinase B activity
GO:0032729
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032755
IMP
Genome Projectpositive regulation of interleukin-6 production
GO:0032880
IEA
Genome Projectregulation of protein localization
GO:0033138
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034613
IDA
Genome Projectcellular protein localization
GO:0035108
IEA
Genome Projectlimb morphogenesis
GO:0035567
IEA
Genome Projectnon-canonical Wnt signaling pathway
GO:0036342
IEA
Genome Projectpost-anal tail morphogenesis
GO:0038031
IEA
Genome Projectnon-canonical Wnt signaling pathway via JNK cascade
GO:0040037
IEA
Genome Projectnegative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060
IDA
Genome Projectwound healing
GO:0042472
IEA
Genome Projectinner ear morphogenesis
GO:0042733
IEA
Genome Projectembryonic digit morphogenesis
GO:0043032
IMP
Genome Projectpositive regulation of macrophage activation
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043507
IEA
Genome Projectpositive regulation of JUN kinase activity
GO:0045080
IMP
Genome Projectpositive regulation of chemokine biosynthetic process
GO:0045165
IBA
Genome Projectcell fate commitment
GO:0045599
IMP
Genome Projectnegative regulation of fat cell differentiation
GO:0045732
IGI
Genome Projectpositive regulation of protein catabolic process
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0045778
IMP
Genome Projectpositive regulation of ossification
GO:0045807
IEA
Genome Projectpositive regulation of endocytosis
GO:0045836
IEA
Genome Projectpositive regulation of meiotic nuclear division
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IEA
Genome Projectpositive regulation of JNK cascade
GO:0046546
IEA
Genome Projectdevelopment of primary male sexual characteristics
GO:0048022
IEA
Genome Projectnegative regulation of melanin biosynthetic process
GO:0048146
IDA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048546
IEA
Genome Projectdigestive tract morphogenesis
GO:0048706
IMP
Genome Projectembryonic skeletal system development
GO:0048806
IMP
Genome Projectgenitalia development
GO:0048812
IEA
Genome Projectneuron projection morphogenesis
GO:0048843
IEA
Genome Projectnegative regulation of axon extension involved in axon guidance
GO:0048850
IEA
Genome Projecthypophysis morphogenesis
GO:0050679
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050680
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050718
IMP
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050729
IMP
Genome Projectpositive regulation of inflammatory response
GO:0050919
IEA
Genome Projectnegative chemotaxis
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051216
IEA
Genome Projectcartilage development
GO:0051964
IEA
Genome Projectnegative regulation of synapse assembly
GO:0060021
IMP
Genome Projectpalate development
GO:0060026
IEA
Genome Projectconvergent extension
GO:0060029
IEA
Genome Projectconvergent extension involved in organogenesis
GO:0060065
IEA
Genome Projectuterus development
GO:0060067
IEA
Genome Projectcervix development
GO:0060068
IEA
Genome Projectvagina development
GO:0060070
IEA
Genome Projectcanonical Wnt signaling pathway
GO:0060157
IEA
Genome Projecturinary bladder development
GO:0060324
IMP
Genome Projectface development
GO:0060340
IDA
Genome Projectpositive regulation of type I interferon-mediated signaling pathway
GO:0060599
IEA
Genome Projectlateral sprouting involved in mammary gland duct morphogenesis
GO:0060606
IEA
Genome Projecttube closure
GO:0060638
IEA
Genome Projectmesenchymal-epithelial cell signaling
GO:0060686
IEA
Genome Projectnegative regulation of prostatic bud formation
GO:0060744
IEA
Genome Projectmammary gland branching involved in thelarche
GO:0060750
IEA
Genome Projectepithelial cell proliferation involved in mammary gland duct elongation
GO:0060760
IDA
Genome Projectpositive regulation of response to cytokine stimulus
GO:0060762
IEA
Genome Projectregulation of branching involved in mammary gland duct morphogenesis
GO:0060907
IMP
Genome Projectpositive regulation of macrophage cytokine production
GO:0061036
IEA
Genome Projectpositive regulation of cartilage development
GO:0061347
IEA
Genome Projectplanar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348
IEA
Genome Projectplanar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349
IEA
Genome Projectplanar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350
IEA
Genome Projectplanar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354
IEA
Genome Projectplanar cell polarity pathway involved in pericardium morphogenesis
GO:0070245
IEA
Genome Projectpositive regulation of thymocyte apoptotic process
GO:0071219
IEA
Genome Projectcellular response to molecule of bacterial origin
GO:0071222
IEP
Genome Projectcellular response to lipopolysaccharide
GO:0071277
IEP
Genome Projectcellular response to calcium ion
GO:0071300
ISS
Genome Projectcellular response to retinoic acid
GO:0071346
IEP
Genome Projectcellular response to interferon-gamma
GO:0071425
IDA
Genome Projecthematopoietic stem cell proliferation
GO:0071542
IEA
Genome Projectdopaminergic neuron differentiation
GO:0071560
IEP
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0072201
IDA
Genome Projectnegative regulation of mesenchymal cell proliferation
GO:0090009
IEA
Genome Projectprimitive streak formation
GO:0090037
IMP
Genome Projectpositive regulation of protein kinase C signaling
GO:0090090
IDA, IGI
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090103
IEA
Genome Projectcochlea morphogenesis
GO:0090179
IEA
Genome Projectplanar cell polarity pathway involved in neural tube closure
GO:0097325
IEA
Genome Projectmelanocyte proliferation
GO:1900020
IMP
Genome Projectpositive regulation of protein kinase C activity
GO:2000049
IEA
Genome Projectpositive regulation of cell-cell adhesion mediated by cadherin
GO:2000052
IEA
Genome Projectpositive regulation of non-canonical Wnt signaling pathway
GO:2000484
IEA
Genome Projectpositive regulation of interleukin-8 secretion

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003700
IMP
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005109
IPI
Genome Projectfrizzled binding
GO:0005110
IEA
Genome Projectfrizzled-2 binding
GO:0005115
IPI
Genome Projectreceptor tyrosine kinase-like orphan receptor binding
GO:0005125
IEA
Genome Projectcytokine activity
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding
GO:0048018
IC
Genome Projectreceptor agonist activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005578
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IDA
Genome Projectextracellular space
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005796
TAS
Genome ProjectGolgi lumen
GO:0005886
TAS
Genome Projectplasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0030669
TAS
Genome Projectclathrin-coated endocytic vesicle membrane
GO:0070062
TAS
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR005817Wnt
IPR018161Wnt protein, conserved site
IPR026538Wnt-5a protein

No MapMan annotations defined for this gene.