Gene: ENSG00000113575 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000113575
Transcript Identifier
ENST00000481195
Gene Type
Coding gene
Location
5 : 134197772-134225861 : negative

Family Information

Homologous gene family
HOM03P000043
(553 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000246
(59 genes in 38 species)
specific family

Descriptions

gene_descr
protein phosphatase 2, catalytic subunit, alpha isozyme

Identifiers

Type Value
pidENSP00000418447
HGNC9299
UniprotP67775
UniprotB3KUN1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006470
TAS, IEA
Genome Projectprotein dephosphorylation
GO:0007498
IEA
Genome Projectmesoderm development
GO:0008152
IEA
Genome Projectmetabolic process
GO:0000184
TAS
Genome Projectnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188
NAS
Genome Projectinactivation of MAPK activity
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0006275
NAS
Genome Projectregulation of DNA replication
GO:0006355
NAS
Genome Projectregulation of transcription, DNA-templated
GO:0006672
NAS
Genome Projectceramide metabolic process
GO:0006915
TAS
Genome Projectapoptotic process
GO:0007084
TAS
Genome Projectmitotic nuclear envelope reassembly
GO:0008380
NAS
Genome ProjectRNA splicing
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010033
NAS
Genome Projectresponse to organic substance
GO:0010467
TAS
Genome Projectgene expression
GO:0010719
IMP
Genome Projectnegative regulation of epithelial to mesenchymal transition
GO:0019932
NAS
Genome Projectsecond-messenger-mediated signaling
GO:0030111
NAS
Genome Projectregulation of Wnt signaling pathway
GO:0030155
NAS
Genome Projectregulation of cell adhesion
GO:0030308
NAS
Genome Projectnegative regulation of cell growth
GO:0040008
NAS
Genome Projectregulation of growth
GO:0042518
NAS
Genome Projectnegative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595
NAS
Genome Projectregulation of cell differentiation
GO:0051321
IEA
Genome Projectmeiotic cell cycle
GO:0071902
IMP
Genome Projectpositive regulation of protein serine/threonine kinase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004721
IEA
Genome Projectphosphoprotein phosphatase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008022
IEA
Genome Projectprotein C-terminus binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0050811
IEA
Genome ProjectGABA receptor binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000775
IEA
Genome Projectchromosome, centromeric region
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0000159
IDA
TAS
Genome Projectprotein phosphatase type 2A complex
GO:0000922
IEA
Genome Projectspindle pole
GO:0005634
NAS, IEA
Genome Projectnucleus
GO:0005694
IEA
Genome Projectchromosome
GO:0005739
NAS
Genome Projectmitochondrion
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0015630
NAS
Genome Projectmicrotubule cytoskeleton
GO:0016020
NAS
Genome Projectmembrane
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR004843Calcineurin-like phosphoesterase domain, apaH type
IPR006186Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052Metallo-dependent phosphatase-like

No MapMan annotations defined for this gene.