Gene: ENSG00000113302 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000113302
Transcript Identifier
ENST00000231228
Gene Type
Coding gene
Location
5 : 159316685-159326782 : negative

Family Information

Homologous gene family
HOM03P042531
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 12B

Identifiers

Type Value
pidENSP00000231228
HGNC5970
UniprotP29460

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001916
ISS
IEA
Genome Projectpositive regulation of T cell mediated cytotoxicity
GO:0002230
IDA
ISS
Genome Projectpositive regulation of defense response to virus by host
GO:0002323
IEA
Genome Projectnatural killer cell activation involved in immune response
GO:0002827
IDA
ISS
Genome Projectpositive regulation of T-helper 1 type immune response
GO:0002860
IDA
Genome Projectpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862
IEA
Genome Projectnegative regulation of inflammatory response to antigenic stimulus
GO:0007050
IDA
Genome Projectcell cycle arrest
GO:0007166
IEA
Genome Projectcell surface receptor signaling pathway
GO:0010224
IDA
Genome Projectresponse to UV-B
GO:0010535
IDA
Genome Projectpositive regulation of activation of JAK2 kinase activity
GO:0016477
IDA
Genome Projectcell migration
GO:0019221
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0019953
TAS
Genome Projectsexual reproduction
GO:0030101
IDA
Genome Projectnatural killer cell activation
GO:0032693
IMP
Genome Projectnegative regulation of interleukin-10 production
GO:0032700
IDA
Genome Projectnegative regulation of interleukin-17 production
GO:0032725
IDA
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729
IDA
Genome Projectpositive regulation of interferon-gamma production
GO:0032733
IDA
TAS
Genome Projectpositive regulation of interleukin-10 production
GO:0032735
IDA
Genome Projectpositive regulation of interleukin-12 production
GO:0032740
IDA
Genome Projectpositive regulation of interleukin-17 production
GO:0032760
IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032816
IDA
IC
Genome Projectpositive regulation of natural killer cell activation
GO:0032819
IDA
Genome Projectpositive regulation of natural killer cell proliferation
GO:0032946
IMP
Genome Projectpositive regulation of mononuclear cell proliferation
GO:0034105
IC
Genome Projectpositive regulation of tissue remodeling
GO:0034393
IDA
Genome Projectpositive regulation of smooth muscle cell apoptotic process
GO:0042035
TAS
Genome Projectregulation of cytokine biosynthetic process
GO:0042088
TAS
Genome ProjectT-helper 1 type immune response
GO:0042093
IDA
Genome ProjectT-helper cell differentiation
GO:0042095
TAS
Genome Projectinterferon-gamma biosynthetic process
GO:0042102
IDA
Genome Projectpositive regulation of T cell proliferation
GO:0042104
IDA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042346
TAS
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042510
IDA
Genome Projectregulation of tyrosine phosphorylation of Stat1 protein
GO:0042517
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832
IEA
Genome Projectdefense response to protozoan
GO:0043382
ISS
Genome Projectpositive regulation of memory T cell differentiation
GO:0044130
IEA
Genome Projectnegative regulation of growth of symbiont in host
GO:0045078
TAS
Genome Projectpositive regulation of interferon-gamma biosynthetic process
GO:0045672
IDA
Genome Projectpositive regulation of osteoclast differentiation
GO:0045785
IDA
Genome Projectpositive regulation of cell adhesion
GO:0048662
IDA
Genome Projectnegative regulation of smooth muscle cell proliferation
GO:0050671
IDA
Genome Projectpositive regulation of lymphocyte proliferation
GO:0050729
IC
Genome Projectpositive regulation of inflammatory response
GO:0050829
IDA
Genome Projectdefense response to Gram-negative bacterium
GO:0051135
IDA
IC
Genome Projectpositive regulation of NK T cell activation
GO:0051142
IDA
Genome Projectpositive regulation of NK T cell proliferation
GO:0051607
IEA
Genome Projectdefense response to virus
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071346
IEA
Genome Projectcellular response to interferon-gamma
GO:2000318
ISS
Genome Projectpositive regulation of T-helper 17 type immune response
GO:2000330
ISS
Genome Projectpositive regulation of T-helper 17 cell lineage commitment

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004896
IEA
Genome Projectcytokine receptor activity
GO:0005125
IDA
IEA
Genome Projectcytokine activity
GO:0005126
IEA
Genome Projectcytokine receptor binding
GO:0005143
TAS
Genome Projectinterleukin-12 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0042164
IPI
IEA
Genome Projectinterleukin-12 alpha subunit binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0046982
IPI
IEA
Genome Projectprotein heterodimerization activity
GO:0008083
IDA
Genome Projectgrowth factor activity
GO:0045519
IDA
Genome Projectinterleukin-23 receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
TAS, IEA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0016020
IEA
Genome Projectmembrane
GO:0043514
IDA
IEA
Genome Projectinterleukin-12 complex
GO:0070743
IDA
Genome Projectinterleukin-23 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003530Long hematopoietin receptor, soluble alpha chain, conserved site
IPR003598Immunoglobulin subtype 2
IPR003961Fibronectin type III
IPR007110Immunoglobulin-like domain
IPR013783Immunoglobulin-like fold
IPR015528Interleukin-12 beta
IPR019482Interleukin-12 beta, central domain

No MapMan annotations defined for this gene.