Gene: ENSG00000109320 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000109320
Transcript Identifier
ENST00000226574
Gene Type
Coding gene
Location
4 : 102525519-102616594 : positive

Family Information

Homologous gene family
HOM03P008110
(10 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P071470
(2 genes in 2 species)
specific family

Descriptions

gene_descr
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Identifiers

Type Value
pidENSP00000226574
HGNC7794
UniprotP19838

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP, IGI
IC
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001818
IEA
Genome Projectnegative regulation of cytokine production
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006366
TAS
Genome Projecttranscription from RNA polymerase II promoter
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006954
TAS
Genome Projectinflammatory response
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007249
IBA
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0010744
IC
Genome Projectpositive regulation of macrophage derived foam cell differentiation
GO:0010884
IC
Genome Projectpositive regulation of lipid storage
GO:0010956
IDA
Genome Projectnegative regulation of calcidiol 1-monooxygenase activity
GO:0010957
IC
Genome Projectnegative regulation of vitamin D biosynthetic process
GO:0031293
TAS
Genome Projectmembrane protein intracellular domain proteolysis
GO:0032269
IC
Genome Projectnegative regulation of cellular protein metabolic process
GO:0032375
IC
Genome Projectnegative regulation of cholesterol transport
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035994
IEA
Genome Projectresponse to muscle stretch
GO:0038061
IBA
Genome ProjectNIK/NF-kappaB signaling
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0043066
TAS, IEA
Genome Projectnegative regulation of apoptotic process
GO:0045083
IEA
Genome Projectnegative regulation of interleukin-12 biosynthetic process
GO:0045087
IBA
TAS
Genome Projectinnate immune response
GO:0045892
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA, IMP
NAS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046688
IEA
Genome Projectresponse to copper ion
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050728
IEA
Genome Projectnegative regulation of inflammatory response
GO:0050852
TAS
Genome ProjectT cell receptor signaling pathway
GO:0051092
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0071222
IMP
Genome Projectcellular response to lipopolysaccharide
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071316
IMP
Genome Projectcellular response to nicotine
GO:0071347
IEP
Genome Projectcellular response to interleukin-1
GO:0071354
IMP
Genome Projectcellular response to interleukin-6
GO:0071375
IMP
Genome Projectcellular response to peptide hormone stimulus
GO:0090263
IMP
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1900127
IDA
Genome Projectpositive regulation of hyaluronan biosynthetic process
GO:2000630
IMP
Genome Projectpositive regulation of miRNA metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000975
IDA
Genome Projectregulatory region DNA binding
GO:0000976
IDA
IEA
Genome Projecttranscription regulatory region sequence-specific DNA binding
GO:0000977
IDA
Genome ProjectRNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980
IDA
Genome ProjectRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001227
IDA
Genome Projecttranscriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003682
IBA
IEA
Genome Projectchromatin binding
GO:0003690
IEA
Genome Projectdouble-stranded DNA binding
GO:0003700
IDA
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IDA
Genome Projecttranscription factor binding
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0042805
IPI
Genome Projectactinin binding
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
TAS, IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005829
IBA
TAS, IEA
Genome Projectcytosol
GO:0033256
TAS
Genome ProjectI-kappaB/NF-kappaB complex
GO:0043234
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000451NF-kappa-B/Dorsal
IPR000488Death domain
IPR002110Ankyrin repeat
IPR002909IPT domain
IPR008967p53-like transcription factor, DNA-binding
IPR011029Death-like domain
IPR011539Rel homology domain (RHD), DNA-binding domain
IPR013783Immunoglobulin-like fold
IPR014756Immunoglobulin E-set
IPR020683Ankyrin repeat-containing domain
IPR030492Rel homology domain, conserved site
IPR030503Nuclear factor NF-kappa-B, p105 subunit
IPR032397Rel homology dimerisation domain

No MapMan annotations defined for this gene.