Gene: ENSG00000108984 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000108984
Transcript Identifier
ENST00000590474
Gene Type
Coding gene
Location
17 : 69414985-69541753 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P029168
(4 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase kinase 6

Identifiers

Type Value
pidENSP00000468348
HGNC6846
UniprotP52564
UniprotA8K3Y2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0000187
IBA
TAS, IEA
Genome Projectactivation of MAPK activity
GO:0001934
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0002931
IEA
Genome Projectresponse to ischemia
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
IEA
Genome Projectapoptotic process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0022602
IEA
Genome Projectovulation cycle process
GO:0032308
IEA
Genome Projectpositive regulation of prostaglandin secretion
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0051770
IEA
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0060048
IEA
Genome Projectcardiac muscle contraction
GO:0072709
IEA
Genome Projectcellular response to sorbitol
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006975
TAS
Genome ProjectDNA damage induced protein phosphorylation
GO:0007050
TAS
Genome Projectcell cycle arrest
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007346
IBA
Genome Projectregulation of mitotic cell cycle
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0023014
IBA
Genome Projectsignal transduction by protein phosphorylation
GO:0031098
IBA
Genome Projectstress-activated protein kinase signaling cascade
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042692
TAS
Genome Projectmuscle cell differentiation
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0051149
TAS
Genome Projectpositive regulation of muscle cell differentiation
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004708
TAS, IEA
Genome ProjectMAP kinase kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0004674
IBA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IPI
Genome Projectprotein kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IBA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.