Gene: ENSG00000108946 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000108946
Transcript Identifier
ENST00000586397
Gene Type
Coding gene
Location
17 : 68515400-68530449 : positive

Family Information

Homologous gene family
HOM03P000470
(100 genes in 25 species)
specific family
Orthologous gene family
ORTHO03P000404
(51 genes in 22 species)
specific family

Descriptions

gene_descr
protein kinase, cAMP-dependent, regulatory, type I, alpha

Identifiers

Type Value
pidENSP00000466459
HGNC9388
UniprotP10644
UniprotB2R5T5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001707
IEA
Genome Projectmesoderm formation
GO:0001932
IEA
Genome Projectregulation of protein phosphorylation
GO:0006469
IEA
Genome Projectnegative regulation of protein kinase activity
GO:0007143
IEA
Genome Projectfemale meiotic division
GO:0007507
IEA
Genome Projectheart development
GO:0016310
IEA
Genome Projectphosphorylation
GO:0045214
IEA
Genome Projectsarcomere organization
GO:0045835
IEA
Genome Projectnegative regulation of meiotic nuclear division
GO:0045859
IEA
Genome Projectregulation of protein kinase activity
GO:0060038
IEA
Genome Projectcardiac muscle cell proliferation
GO:0003091
TAS
Genome Projectrenal water homeostasis
GO:0006112
TAS
Genome Projectenergy reserve metabolic process
GO:0006357
TAS
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006833
TAS
Genome Projectwater transport
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007202
TAS
Genome Projectactivation of phospholipase C activity
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0034199
TAS
Genome Projectactivation of protein kinase A activity
GO:0035556
TAS
Genome Projectintracellular signal transduction
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0046007
IMP
Genome Projectnegative regulation of activated T cell proliferation
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050796
TAS
Genome Projectregulation of insulin secretion
GO:0055085
TAS
Genome Projecttransmembrane transport
GO:0071377
TAS
Genome Projectcellular response to glucagon stimulus
GO:2000480
IDA
Genome Projectnegative regulation of cAMP-dependent protein kinase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008603
IDA
TAS, IEA
Genome ProjectcAMP-dependent protein kinase regulator activity
GO:0016301
IEA
Genome Projectkinase activity
GO:0030552
IEA
Genome ProjectcAMP binding
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004862
IDA
Genome ProjectcAMP-dependent protein kinase inhibitor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0031625
IDA
Genome Projectubiquitin protein ligase binding
GO:0034236
IPI
Genome Projectprotein kinase A catalytic subunit binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005952
IEA
Genome ProjectcAMP-dependent protein kinase complex
GO:0031594
IEA
Genome Projectneuromuscular junction
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0031588
IDA
Genome Projectnucleotide-activated protein kinase complex
GO:0043234
IDA
Genome Projectprotein complex
GO:0044853
IDA
Genome Projectplasma membrane raft
GO:0097546
TAS
Genome Projectciliary base
GO:0001772
IDA
Genome Projectimmunological synapse

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000595Cyclic nucleotide-binding domain
IPR003117cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
IPR012198cAMP-dependent protein kinase regulatory subunit
IPR014710RmlC-like jelly roll fold
IPR018488Cyclic nucleotide-binding, conserved site
IPR018490Cyclic nucleotide-binding-like

No MapMan annotations defined for this gene.