Gene: ENSG00000107643 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000107643
Transcript Identifier
ENST00000374176
Gene Type
Coding gene
Location
10 : 48401661-48435029 : positive

Family Information

Homologous gene family
HOM03P000009
(1563 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P011492
(7 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase 8

Identifiers

Type Value
pidENSP00000363291
HGNC6881
UniprotP45983
UniprotA1L4K2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0001503
IEA
Genome Projectossification
GO:0001764
IEA
Genome Projectneuron migration
GO:0006468
IMP
IEA
Genome Projectprotein phosphorylation
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0016310
IEA
Genome Projectphosphorylation
GO:0042752
ISS
IEA
Genome Projectregulation of circadian rhythm
GO:0046686
IEA
Genome Projectresponse to cadmium ion
GO:0048813
IEA
Genome Projectdendrite morphogenesis
GO:0070301
IEA
Genome Projectcellular response to hydrogen peroxide
GO:0071732
IEA
Genome Projectcellular response to nitric oxide
GO:0097300
IEA
Genome Projectprogrammed necrotic cell death
GO:2000017
IEA
Genome Projectpositive regulation of determination of dorsal identity
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006950
TAS
Genome Projectresponse to stress
GO:0007254
IDA
TAS
Genome ProjectJNK cascade
GO:0007258
IDA
Genome ProjectJUN phosphorylation
GO:0009411
IDA
Genome Projectresponse to UV
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
IDA, IMP
Genome Projectpeptidyl-threonine phosphorylation
GO:0031063
IMP
Genome Projectregulation of histone deacetylation
GO:0031281
IMP
Genome Projectpositive regulation of cyclase activity
GO:0032091
IDA
Genome Projectnegative regulation of protein binding
GO:0032880
IDA
Genome Projectregulation of protein localization
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048511
IEA
Genome Projectrhythmic process
GO:0051090
TAS
Genome Projectregulation of sequence-specific DNA binding transcription factor activity
GO:0051247
IMP
Genome Projectpositive regulation of protein metabolic process
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0090045
IMP
Genome Projectpositive regulation of deacetylase activity
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004707
IEA
Genome ProjectMAP kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0004705
IDA
Genome ProjectJUN kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0035033
IMP
Genome Projecthistone deacetylase regulator activity
GO:0042826
IPI
Genome Projecthistone deacetylase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003527Mitogen-activated protein (MAP) kinase, conserved site
IPR008271Serine/threonine-protein kinase, active site
IPR008351Mitogen-activated protein (MAP) kinase, JNK
IPR011009Protein kinase-like domain

No MapMan annotations defined for this gene.