Gene: ENSG00000106991 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000106991
Transcript Identifier
ENST00000373203
Gene Type
Coding gene
Location
9 : 127815682-127854355 : negative

Family Information

Homologous gene family
HOM03P047712
(2 genes in 2 species)
specific family

Descriptions

gene_descr
endoglin

Identifiers

Type Value
pidENSP00000362299
HGNC3349
UniprotP17813
UniprotA0A024R878

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001300
IEP
IEA
Genome Projectchronological cell aging
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001569
ISS
IEA
Genome Projectpatterning of blood vessels
GO:0001947
ISS
IEA
Genome Projectheart looping
GO:0003273
IEA
Genome Projectcell migration involved in endocardial cushion formation
GO:0007507
IEA
Genome Projectheart development
GO:0048745
ISS
IEA
Genome Projectsmooth muscle tissue development
GO:0048844
ISS
IEA
Genome Projectartery morphogenesis
GO:0048845
ISS
IEA
Genome Projectvenous blood vessel morphogenesis
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001570
IMP
Genome Projectvasculogenesis
GO:0001666
IDA
Genome Projectresponse to hypoxia
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001937
IMP
Genome Projectnegative regulation of endothelial cell proliferation
GO:0003084
IMP
Genome Projectpositive regulation of systemic arterial blood pressure
GO:0006355
IMP
Genome Projectregulation of transcription, DNA-templated
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007179
IDA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0010862
IDA, IMP
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016477
IMP
Genome Projectcell migration
GO:0017015
IDA
Genome Projectregulation of transforming growth factor beta receptor signaling pathway
GO:0022009
IMP
Genome Projectcentral nervous system vasculogenesis
GO:0022617
IMP
Genome Projectextracellular matrix disassembly
GO:0030155
TAS
Genome Projectregulation of cell adhesion
GO:0030336
IDA
Genome Projectnegative regulation of cell migration
GO:0030509
TAS
Genome ProjectBMP signaling pathway
GO:0030512
TAS
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0030513
IDA
Genome Projectpositive regulation of BMP signaling pathway
GO:0031953
IDA
Genome Projectnegative regulation of protein autophosphorylation
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0042060
IMP
Genome Projectwound healing
GO:0042127
TAS
Genome Projectregulation of cell proliferation
GO:0042325
TAS
Genome Projectregulation of phosphorylation
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048870
IMP
Genome Projectcell motility
GO:0051001
IMP
Genome Projectnegative regulation of nitric-oxide synthase activity
GO:0060326
IMP
Genome Projectcell chemotaxis
GO:0060394
IMP
Genome Projectnegative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070483
IDA
Genome Projectdetection of hypoxia

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004888
NAS
Genome Projecttransmembrane signaling receptor activity
GO:0005024
IDA
Genome Projecttransforming growth factor beta-activated receptor activity
GO:0005072
IDA
Genome Projecttransforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005114
IPI
ISS
Genome Projecttype II transforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005534
IDA
Genome Projectgalactose binding
GO:0005539
IDA
ISS
Genome Projectglycosaminoglycan binding
GO:0034713
IPI
ISS
Genome Projecttype I transforming growth factor beta receptor binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0048185
TAS
Genome Projectactivin binding
GO:0050431
IPI
Genome Projecttransforming growth factor beta binding
GO:0036122
IPI
Genome ProjectBMP binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0072563
IEA
Genome Projectendothelial microparticle
GO:0005615
IDA
Genome Projectextracellular space
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043235
IPI
Genome Projectreceptor complex
GO:0070022
IC
Genome Projecttransforming growth factor beta receptor homodimeric complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001507Zona pellucida domain

No MapMan annotations defined for this gene.