Gene: ENSG00000106366 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000106366
Transcript Identifier
ENST00000223095
Gene Type
Coding gene
Location
7 : 101128394-101137442 : positive

Family Information

Homologous gene family
HOM03P000183
(176 genes in 15 species)
specific family

Descriptions

gene_descr
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Identifiers

Type Value
pidENSP00000223095
HGNC8583
UniprotP05121
UniprotA0A024QYT5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001300
IEP
Genome Projectchronological cell aging
GO:0001525
IEP
Genome Projectangiogenesis
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0006351
TAS
Genome Projecttranscription, DNA-templated
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0007179
TAS
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007596
TAS
Genome Projectblood coagulation
GO:0007623
TAS
Genome Projectcircadian rhythm
GO:0010466
IEA
Genome Projectnegative regulation of peptidase activity
GO:0010467
TAS
Genome Projectgene expression
GO:0010469
IDA
Genome Projectregulation of receptor activity
GO:0010757
IDA, IMP
Genome Projectnegative regulation of plasminogen activation
GO:0010951
IDA
Genome Projectnegative regulation of endopeptidase activity
GO:0014912
IDA
Genome Projectnegative regulation of smooth muscle cell migration
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030194
IMP
Genome Projectpositive regulation of blood coagulation
GO:0030195
IC
Genome Projectnegative regulation of blood coagulation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030336
IDA
Genome Projectnegative regulation of cell migration
GO:0032757
IMP
Genome Projectpositive regulation of interleukin-8 production
GO:0033629
IDA
Genome Projectnegative regulation of cell adhesion mediated by integrin
GO:0035491
IMP
Genome Projectpositive regulation of leukotriene production involved in inflammatory response
GO:0042730
TAS
Genome Projectfibrinolysis
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0045944
TAS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048260
IDA
Genome Projectpositive regulation of receptor-mediated endocytosis
GO:0050729
IGI
Genome Projectpositive regulation of inflammatory response
GO:0050829
IGI
Genome Projectdefense response to Gram-negative bacterium
GO:0051918
IDA
Genome Projectnegative regulation of fibrinolysis
GO:0061044
IGI
Genome Projectnegative regulation of vascular wound healing
GO:0061045
IC
Genome Projectnegative regulation of wound healing
GO:0071222
IMP
Genome Projectcellular response to lipopolysaccharide
GO:0090026
IMP
Genome Projectpositive regulation of monocyte chemotaxis
GO:1902042
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098
IDA
Genome Projectnegative regulation of smooth muscle cell-matrix adhesion
GO:2000352
IMP
Genome Projectnegative regulation of endothelial cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
Genome Projectprotease binding
GO:0004867
IDA
IEA
Genome Projectserine-type endopeptidase inhibitor activity
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0030414
IEA
Genome Projectpeptidase inhibitor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005576
IDA
TAS, IEA
Genome Projectextracellular region
GO:0005886
TAS
Genome Projectplasma membrane
GO:0031012
IDA
Genome Projectextracellular matrix
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000215Serpin family
IPR023795Serpin, conserved site
IPR023796Serpin domain

No MapMan annotations defined for this gene.