Gene: ENSG00000106144 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000106144
Transcript Identifier
ENST00000310447
Gene Type
Coding gene
Location
7 : 143288456-143305071 : positive

Family Information

Homologous gene family
HOM03P003300
(30 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P075821
(2 genes in 2 species)
specific family

Descriptions

gene_descr
caspase 2, apoptosis-related cysteine peptidase

Identifiers

Type Value
pidENSP00000312664
HGNC1503
UniprotP42575

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001554
IEA
Genome Projectluteolysis
GO:0003407
IEA
Genome Projectneural retina development
GO:0006508
IEA
Genome Projectproteolysis
GO:0006915
IBA
NAS, IEA
Genome Projectapoptotic process
GO:0006919
IBA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977
IMP
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420
IEA
Genome Projectbrain development
GO:0007568
IEA
Genome Projectaging
GO:0008630
TAS
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0016485
IDA
Genome Projectprotein processing
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043281
TAS
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0097190
TAS, IEA
Genome Projectapoptotic signaling pathway
GO:0097192
IBA
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097194
TAS
Genome Projectexecution phase of apoptosis
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004197
IDA
IEA
Genome Projectcysteine-type endopeptidase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008234
IEA
Genome Projectcysteine-type peptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0019899
ISS
Genome Projectenzyme binding
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0097153
IEA
Genome Projectcysteine-type endopeptidase activity involved in apoptotic process
GO:0097199
IBA
Genome Projectcysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
TAS, IEA
Genome Projectnucleus
GO:0005737
IBA
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005829
TAS
Genome Projectcytosol
GO:0016020
IEA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001309Peptidase C14, ICE, catalytic subunit p20
IPR001315CARD domain
IPR002138Peptidase C14, caspase non-catalytic subunit p10
IPR011029Death-like domain
IPR011600Peptidase C14, caspase domain
IPR015917Peptidase C14A, caspase precursor p45, core
IPR016129Peptidase C14, ICE, catalytic subunit p20, active site
IPR017350Peptidase C14A, Casp1-type
IPR029030Caspase-like domain

No MapMan annotations defined for this gene.