Gene: ENSG00000105974 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000105974
Transcript Identifier
ENST00000341049
Gene Type
Coding gene
Location
7 : 116525063-116559287 : positive

Family Information

Homologous gene family
HOM03P011276
(7 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P042841
(3 genes in 3 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
caveolin 1, caveolae protein, 22kDa

Identifiers

Type Value
pidENSP00000339191
HGNC1527
UniprotQ03135
UniprotQ2TNI1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0000188
ISS
IEA
Genome Projectinactivation of MAPK activity
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001570
ISS
IEA
Genome Projectvasculogenesis
GO:0001666
ISS
IEA
Genome Projectresponse to hypoxia
GO:0001937
ISS
IEA
Genome Projectnegative regulation of endothelial cell proliferation
GO:0001938
IEA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001960
IEA
Genome Projectnegative regulation of cytokine-mediated signaling pathway
GO:0002026
IEA
Genome Projectregulation of the force of heart contraction
GO:0002931
IEA
Genome Projectresponse to ischemia
GO:0003057
IEA
Genome Projectregulation of the force of heart contraction by chemical signal
GO:0006641
ISS
IEA
Genome Projecttriglyceride metabolic process
GO:0006816
ISS
IEA
Genome Projectcalcium ion transport
GO:0006874
ISS
IEA
Genome Projectcellular calcium ion homeostasis
GO:0006940
ISS
IEA
Genome Projectregulation of smooth muscle contraction
GO:0007519
ISS
IEA
Genome Projectskeletal muscle tissue development
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0007595
IEA
Genome Projectlactation
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008104
ISS
IEA
Genome Projectprotein localization
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009267
IEP
Genome Projectcellular response to starvation
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009617
IDA
Genome Projectresponse to bacterium
GO:0009967
IEA
Genome Projectpositive regulation of signal transduction
GO:0009968
IEA
Genome Projectnegative regulation of signal transduction
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010524
ISS
IEA
Genome Projectpositive regulation of calcium ion transport into cytosol
GO:0010608
IEA
Genome Projectposttranscriptional regulation of gene expression
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010656
IEA
Genome Projectnegative regulation of muscle cell apoptotic process
GO:0010952
IEA
Genome Projectpositive regulation of peptidase activity
GO:0016032
IEA
Genome Projectviral process
GO:0016050
ISS
Genome Projectvesicle organization
GO:0019065
IGI
Genome Projectreceptor-mediated endocytosis of virus by host cell
GO:0019217
ISS
IEA
Genome Projectregulation of fatty acid metabolic process
GO:0019915
ISS
IEA
Genome Projectlipid storage
GO:0030193
IMP
Genome Projectregulation of blood coagulation
GO:0030301
TAS
Genome Projectcholesterol transport
GO:0030514
IDA
Genome Projectnegative regulation of BMP signaling pathway
GO:0030857
ISS
IEA
Genome Projectnegative regulation of epithelial cell differentiation
GO:0030879
ISS
IEA
Genome Projectmammary gland development
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0031116
IEA
Genome Projectpositive regulation of microtubule polymerization
GO:0031295
IDA
Genome ProjectT cell costimulation
GO:0031397
IMP
Genome Projectnegative regulation of protein ubiquitination
GO:0031398
IMP
Genome Projectpositive regulation of protein ubiquitination
GO:0032091
IDA
Genome Projectnegative regulation of protein binding
GO:0032092
IMP
Genome Projectpositive regulation of protein binding
GO:0032507
ISS
Genome Projectmaintenance of protein location in cell
GO:0032570
IDA
Genome Projectresponse to progesterone
GO:0033137
IDA
Genome Projectnegative regulation of peptidyl-serine phosphorylation
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033344
IEA
Genome Projectcholesterol efflux
GO:0033484
ISS
IEA
Genome Projectnitric oxide homeostasis
GO:0034141
IMP
Genome Projectpositive regulation of toll-like receptor 3 signaling pathway
GO:0042060
IEA
Genome Projectwound healing
GO:0042310
IEA
Genome Projectvasoconstriction
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042524
IEA
Genome Projectnegative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042632
ISS
TAS, IEA
Genome Projectcholesterol homeostasis
GO:0043407
IEA
Genome Projectnegative regulation of MAP kinase activity
GO:0043409
ISS
IEA
Genome Projectnegative regulation of MAPK cascade
GO:0043627
IDA
IEA
Genome Projectresponse to estrogen
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0044860
ISS
Genome Projectprotein localization to plasma membrane raft
GO:0045019
ISS
IEA
Genome Projectnegative regulation of nitric oxide biosynthetic process
GO:0045665
IEA
Genome Projectnegative regulation of neuron differentiation
GO:0045807
IEA
Genome Projectpositive regulation of endocytosis
GO:0045907
ISS
IEA
Genome Projectpositive regulation of vasoconstriction
GO:0046209
TAS
Genome Projectnitric oxide metabolic process
GO:0046426
ISS
IEA
Genome Projectnegative regulation of JAK-STAT cascade
GO:0046785
IEA
Genome Projectmicrotubule polymerization
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048550
IMP
Genome Projectnegative regulation of pinocytosis
GO:0048554
ISS
IEA
Genome Projectpositive regulation of metalloenzyme activity
GO:0048662
IEA
Genome Projectnegative regulation of smooth muscle cell proliferation
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0050999
TAS
Genome Projectregulation of nitric-oxide synthase activity
GO:0051001
IEA
Genome Projectnegative regulation of nitric-oxide synthase activity
GO:0051259
IEA
Genome Projectprotein oligomerization
GO:0051260
ISS
IEA
Genome Projectprotein homooligomerization
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051480
IDA
Genome Projectcytosolic calcium ion homeostasis
GO:0051592
ISS
IEA
Genome Projectresponse to calcium ion
GO:0051899
ISS
IEA
Genome Projectmembrane depolarization
GO:0052547
ISS
IEA
Genome Projectregulation of peptidase activity
GO:0055074
ISS
IEA
Genome Projectcalcium ion homeostasis
GO:0060056
ISS
IEA
Genome Projectmammary gland involution
GO:0060355
IMP
Genome Projectpositive regulation of cell adhesion molecule production
GO:0060546
IEA
Genome Projectnegative regulation of necroptotic process
GO:0061099
IMP
Genome Projectnegative regulation of protein tyrosine kinase activity
GO:0070373
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070836
IMP, IGI
ISS
IEA
Genome Projectcaveola assembly
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071360
IMP
Genome Projectcellular response to exogenous dsRNA
GO:0071375
ISS
IEA
Genome Projectcellular response to peptide hormone stimulus
GO:0071455
IMP
Genome Projectcellular response to hyperoxia
GO:0071560
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0072584
IDA
Genome Projectcaveolin-mediated endocytosis
GO:0086091
ISS
IEA
Genome Projectregulation of heart rate by cardiac conduction
GO:0086098
ISS
IEA
Genome Projectangiotensin-activated signaling pathway involved in heart process
GO:0090090
ISS
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090263
IMP
TAS
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:0090398
IEA
Genome Projectcellular senescence
GO:0097190
IMP
Genome Projectapoptotic signaling pathway
GO:0098903
IMP
Genome Projectregulation of membrane repolarization during action potential
GO:0098909
IC
Genome Projectregulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0098911
ISS
IEA
Genome Projectregulation of ventricular cardiac muscle cell action potential
GO:1900027
IDA
Genome Projectregulation of ruffle assembly
GO:1900085
IMP
Genome Projectnegative regulation of peptidyl-tyrosine autophosphorylation
GO:1901380
IMP
Genome Projectnegative regulation of potassium ion transmembrane transport
GO:1901844
ISS
IEA
Genome Projectregulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901979
IMP
Genome Projectregulation of inward rectifier potassium channel activity
GO:1903071
IC
Genome Projectpositive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903361
ISS
Genome Projectprotein localization to basolateral plasma membrane
GO:1903598
ISS
IEA
Genome Projectpositive regulation of gap junction assembly
GO:2000286
IMP
Genome Projectreceptor internalization involved in canonical Wnt signaling pathway
GO:2000535
IDA
Genome Projectregulation of entry of bacterium into host cell
GO:2000811
IMP
Genome Projectnegative regulation of anoikis
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001244
IMP
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway
GO:2001258
IEA
Genome Projectnegative regulation of cation channel activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000149
IEA
Genome ProjectSNARE binding
GO:0001179
IEA
Genome ProjectRNA polymerase I transcription factor binding
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005113
NAS
Genome Projectpatched binding
GO:0005198
IDA
Genome Projectstructural molecule activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0015485
TAS
Genome Projectcholesterol binding
GO:0016504
ISS
IEA
Genome Projectpeptidase activator activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019900
IEA
Genome Projectkinase binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019905
IEA
Genome Projectsyntaxin binding
GO:0030674
IEA
Genome Projectprotein binding, bridging
GO:0032947
TAS, IEA
Genome Projectprotein complex scaffold
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0044325
IPI
Genome Projection channel binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0048365
IPI
Genome ProjectRac GTPase binding
GO:0050998
IPI
IEA
Genome Projectnitric-oxide synthase binding
GO:0051117
IPI
Genome ProjectATPase binding
GO:0070320
IDA
Genome Projectinward rectifier potassium channel inhibitor activity
GO:0097371
IEA
Genome ProjectMDM2/MDM4 family protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
IDA
TAS, IEA
Genome ProjectGolgi membrane
GO:0002080
IEA
Genome Projectacrosomal membrane
GO:0005622
IDA
Genome Projectintracellular
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005768
IDA
Genome Projectendosome
GO:0005778
IEA
Genome Projectperoxisomal membrane
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005789
TAS
Genome Projectendoplasmic reticulum membrane
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005811
TAS, IEA
Genome Projectlipid particle
GO:0005829
IEA
Genome Projectcytosol
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IEA
Genome Projectintegral component of plasma membrane
GO:0005901
IDA
NAS, IEA
Genome Projectcaveola
GO:0005925
IDA
IEA
Genome Projectfocal adhesion
GO:0005929
IEA
Genome Projectcilium
GO:0005938
IEA
Genome Projectcell cortex
GO:0009925
IEA
Genome Projectbasal plasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
IDA
Genome Projectbasolateral plasma membrane
GO:0016324
IDA
Genome Projectapical plasma membrane
GO:0030666
TAS
Genome Projectendocytic vesicle membrane
GO:0031410
IDA
IEA
Genome Projectcytoplasmic vesicle
GO:0031901
TAS
Genome Projectearly endosome membrane
GO:0043234
IDA
IEA
Genome Projectprotein complex
GO:0045121
IDA
IEA
Genome Projectmembrane raft
GO:0048471
IDA
ISS
Genome Projectperinuclear region of cytoplasm
GO:0034098
IPI
Genome ProjectVCP-NPL4-UFD1 AAA ATPase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001612Caveolin
IPR015504Caveolin-1
IPR018361Caveolin, conserved site

No MapMan annotations defined for this gene.