Gene: ENSG00000105810 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000105810
Transcript Identifier
ENST00000424848
Gene Type
Coding gene
Location
7 : 92615140-92833323 : negative

Family Information

Homologous gene family
HOM03P000009
(1563 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P038501
(3 genes in 3 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
cyclin-dependent kinase 6

Identifiers

Type Value
pidENSP00000397087
HGNC1777
UniprotQ00534

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000082
TAS
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0001954
IDA
Genome Projectpositive regulation of cell-matrix adhesion
GO:0002244
IEA
Genome Projecthematopoietic progenitor cell differentiation
GO:0003323
IDA
Genome Projecttype B pancreatic cell development
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0007049
IEA
Genome Projectcell cycle
GO:0007050
TAS
Genome Projectcell cycle arrest
GO:0007219
IEA
Genome ProjectNotch signaling pathway
GO:0008285
TAS
Genome Projectnegative regulation of cell proliferation
GO:0009615
IEP
Genome Projectresponse to virus
GO:0010468
IDA, IMP
Genome Projectregulation of gene expression
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0014002
ISS
Genome Projectastrocyte development
GO:0016310
IEA
Genome Projectphosphorylation
GO:0021542
ISS
Genome Projectdentate gyrus development
GO:0021670
ISS
Genome Projectlateral ventricle development
GO:0030097
IEA
Genome Projecthemopoiesis
GO:0030154
IEA
Genome Projectcell differentiation
GO:0033077
IEA
Genome ProjectT cell differentiation in thymus
GO:0042063
IMP
Genome Projectgliogenesis
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0043697
IMP
IEA
Genome Projectcell dedifferentiation
GO:0045596
TAS
Genome Projectnegative regulation of cell differentiation
GO:0045638
IDA
Genome Projectnegative regulation of myeloid cell differentiation
GO:0045646
IMP
Genome Projectregulation of erythrocyte differentiation
GO:0045668
IDA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045786
IDA
Genome Projectnegative regulation of cell cycle
GO:0048146
IMP
Genome Projectpositive regulation of fibroblast proliferation
GO:0048699
ISS
Genome Projectgeneration of neurons
GO:0050680
IMP
Genome Projectnegative regulation of epithelial cell proliferation
GO:0051301
IEA
Genome Projectcell division
GO:0060218
IEA
Genome Projecthematopoietic stem cell differentiation
GO:2000145
ISS
Genome Projectregulation of cell motility
GO:2000773
IDA
Genome Projectnegative regulation of cellular senescence

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004693
IDA
IEA
Genome Projectcyclin-dependent protein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0030332
IPI
IEA
Genome Projectcyclin binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000307
IDA
Genome Projectcyclin-dependent protein kinase holoenzyme complex
GO:0001726
IDA
IEA
Genome Projectruffle
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005813
IDA
Genome Projectcentrosome
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0042995
IEA
Genome Projectcell projection

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR028788Cyclin-dependent kinase 6

No MapMan annotations defined for this gene.