Gene: ENSG00000104884 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000104884
Transcript Identifier
ENST00000391945
Gene Type
Coding gene
Location
19 : 45351629-45370540 : negative

Family Information

Homologous gene family
HOM03P000192
(174 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000850
(43 genes in 39 species)
specific family

Descriptions

gene_descr
excision repair cross-complementation group 2

Identifiers

Type Value
pidENSP00000375809
HGNC3434
UniprotP18074

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000718
TAS
Genome Projectnucleotide-excision repair, DNA damage removal
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0006139
IEA
Genome Projectnucleobase-containing compound metabolic process
GO:0006281
TAS, IEA
Genome ProjectDNA repair
GO:0006283
IDA
TAS
Genome Projecttranscription-coupled nucleotide-excision repair
GO:0006289
IGI
TAS, NAS, IEA
Genome Projectnucleotide-excision repair
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006360
TAS
Genome Projecttranscription from RNA polymerase I promoter
GO:0006361
TAS
Genome Projecttranscription initiation from RNA polymerase I promoter
GO:0006362
TAS
Genome Projecttranscription elongation from RNA polymerase I promoter
GO:0006363
TAS
Genome Projecttermination of RNA polymerase I transcription
GO:0006366
IDA
TAS
Genome Projecttranscription from RNA polymerase II promoter
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006368
TAS
Genome Projecttranscription elongation from RNA polymerase II promoter
GO:0006370
TAS
Genome Project7-methylguanosine mRNA capping
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0006915
IMP
Genome Projectapoptotic process
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006979
IMP
Genome Projectresponse to oxidative stress
GO:0007059
IMP
IEA
Genome Projectchromosome segregation
GO:0007568
IEA
Genome Projectaging
GO:0008283
IEA
Genome Projectcell proliferation
GO:0009411
IEA
Genome Projectresponse to UV
GO:0009650
IGI
Genome ProjectUV protection
GO:0009791
IEA
Genome Projectpost-embryonic development
GO:0010467
TAS
Genome Projectgene expression
GO:0016032
TAS, IEA
Genome Projectviral process
GO:0021510
IEA
Genome Projectspinal cord development
GO:0022405
IEA
Genome Projecthair cycle process
GO:0030198
IEA
Genome Projectextracellular matrix organization
GO:0030282
IEA
Genome Projectbone mineralization
GO:0032289
IEA
Genome Projectcentral nervous system myelin formation
GO:0032508
IDA
IEA
Genome ProjectDNA duplex unwinding
GO:0033683
IMP
Genome Projectnucleotide-excision repair, DNA incision
GO:0035264
IEA
Genome Projectmulticellular organism growth
GO:0035315
IMP
Genome Projecthair cell differentiation
GO:0040016
IEA
Genome Projectembryonic cleavage
GO:0040029
TAS
Genome Projectregulation of gene expression, epigenetic
GO:0043249
IEA
Genome Projecterythrocyte maturation
GO:0043388
IEA
Genome Projectpositive regulation of DNA binding
GO:0043588
IEA
Genome Projectskin development
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045814
TAS
Genome Projectnegative regulation of gene expression, epigenetic
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048820
IEA
Genome Projecthair follicle maturation
GO:0050434
TAS
Genome Projectpositive regulation of viral transcription
GO:0060218
IEA
Genome Projecthematopoietic stem cell differentiation
GO:1901990
IMP
Genome Projectregulation of mitotic cell cycle phase transition

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003676
IEA
Genome Projectnucleic acid binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0004003
IEA
Genome ProjectATP-dependent DNA helicase activity
GO:0004386
IEA
Genome Projecthelicase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008022
IPI
Genome Projectprotein C-terminus binding
GO:0008026
IEA
Genome ProjectATP-dependent helicase activity
GO:0008094
IDA
TAS
Genome ProjectDNA-dependent ATPase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016818
IEA
Genome Projecthydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0043139
IDA
Genome Project5'-3' DNA helicase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0047485
IPI
Genome Projectprotein N-terminus binding
GO:0051536
IEA
Genome Projectiron-sulfur cluster binding
GO:0051539
IEA
Genome Project4 iron, 4 sulfur cluster binding
GO:0004672
IDA
Genome Projectprotein kinase activity
GO:0008353
IDA
Genome ProjectRNA polymerase II carboxy-terminal domain kinase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000439
IEA
Genome Projectcore TFIIH complex
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005675
IDA
TAS
Genome Projectholo TFIIH complex
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005819
IDA
IEA
Genome Projectspindle
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0071817
IDA
Genome ProjectMMXD complex
GO:0019907
IDA
Genome Projectcyclin-dependent protein kinase activating kinase holoenzyme complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001945Xeroderma pigmentosum group D protein
IPR002464DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
IPR006554Helicase-like, DEXD box c2 type
IPR006555ATP-dependent helicase, C-terminal
IPR010614DEAD2
IPR010643Helical and beta-bridge domain
IPR013020DNA helicase (DNA repair), Rad3 type
IPR014013Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.