Gene: ENSG00000104332 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000104332
Transcript Identifier
ENST00000220772
Gene Type
Coding gene
Location
8 : 41265167-41309159 : negative

Family Information

Homologous gene family
HOM03P002165
(40 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P066970
(2 genes in 2 species)
specific family

Descriptions

gene_descr
secreted frizzled-related protein 1

Identifiers

Type Value
pidENSP00000220772
HGNC10776
UniprotQ8N474

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001649
IEP
Genome Projectosteoblast differentiation
GO:0001657
IEA
Genome Projectureteric bud development
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0001843
IEA
Genome Projectneural tube closure
GO:0001954
ISS
Genome Projectpositive regulation of cell-matrix adhesion
GO:0002244
IDA
Genome Projecthematopoietic progenitor cell differentiation
GO:0006508
IMP
Genome Projectproteolysis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0008584
IEA
Genome Projectmale gonad development
GO:0008585
IEA
Genome Projectfemale gonad development
GO:0009267
IEP
Genome Projectcellular response to starvation
GO:0009950
IDA
Genome Projectdorsal/ventral axis specification
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0010564
IMP
Genome Projectregulation of cell cycle process
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010719
IDA
Genome Projectnegative regulation of epithelial to mesenchymal transition
GO:0014034
IEA
Genome Projectneural crest cell fate commitment
GO:0014070
IDA
Genome Projectresponse to organic cyclic compound
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0021915
IEA
Genome Projectneural tube development
GO:0022601
IEP
Genome Projectmenstrual cycle phase
GO:0030097
IEA
Genome Projecthemopoiesis
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030177
IDA
Genome Projectpositive regulation of Wnt signaling pathway
GO:0030178
IDA, IMP
Genome Projectnegative regulation of Wnt signaling pathway
GO:0030278
IEA
Genome Projectregulation of ossification
GO:0030279
IDA, IMP
Genome Projectnegative regulation of ossification
GO:0030307
IDA
Genome Projectpositive regulation of cell growth
GO:0030308
IDA
Genome Projectnegative regulation of cell growth
GO:0030336
IDA
Genome Projectnegative regulation of cell migration
GO:0030514
IEA
Genome Projectnegative regulation of BMP signaling pathway
GO:0033689
IMP
Genome Projectnegative regulation of osteoblast proliferation
GO:0035019
IEA
Genome Projectsomatic stem cell population maintenance
GO:0035567
IBA
Genome Projectnon-canonical Wnt signaling pathway
GO:0042493
IDA
Genome Projectresponse to drug
GO:0043065
IDA, IMP
Genome Projectpositive regulation of apoptotic process
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043508
IEA
Genome Projectnegative regulation of JUN kinase activity
GO:0043547
ISS
Genome Projectpositive regulation of GTPase activity
GO:0044344
IDA
Genome Projectcellular response to fibroblast growth factor stimulus
GO:0044345
IEA
Genome Projectstromal-epithelial cell signaling involved in prostate gland development
GO:0045578
IMP
Genome Projectnegative regulation of B cell differentiation
GO:0045600
IDA
Genome Projectpositive regulation of fat cell differentiation
GO:0045668
IEA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045671
IEA
Genome Projectnegative regulation of osteoclast differentiation
GO:0045765
ISS
Genome Projectregulation of angiogenesis
GO:0045880
IMP
Genome Projectpositive regulation of smoothened signaling pathway
GO:0045892
IDA, IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA, IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0046546
IEA
Genome Projectdevelopment of primary male sexual characteristics
GO:0046676
IDA
Genome Projectnegative regulation of insulin secretion
GO:0046851
IMP
Genome Projectnegative regulation of bone remodeling
GO:0048147
IDA
Genome Projectnegative regulation of fibroblast proliferation
GO:0048546
IEA
Genome Projectdigestive tract morphogenesis
GO:0050679
IMP
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050680
IDA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050732
IDA
Genome Projectnegative regulation of peptidyl-tyrosine phosphorylation
GO:0051496
ISS
Genome Projectpositive regulation of stress fiber assembly
GO:0051894
ISS
Genome Projectpositive regulation of focal adhesion assembly
GO:0060070
IDA
Genome Projectcanonical Wnt signaling pathway
GO:0060071
IEA
Genome ProjectWnt signaling pathway, planar cell polarity pathway
GO:0060218
IDA
Genome Projecthematopoietic stem cell differentiation
GO:0060346
IEA
Genome Projectbone trabecula formation
GO:0060527
IEA
Genome Projectprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687
IEA
Genome Projectregulation of branching involved in prostate gland morphogenesis
GO:0060766
IDA
Genome Projectnegative regulation of androgen receptor signaling pathway
GO:0071305
IEP
Genome Projectcellular response to vitamin D
GO:0071347
IEP
Genome Projectcellular response to interleukin-1
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor
GO:0071363
IDA
Genome Projectcellular response to growth factor stimulus
GO:0071380
IEP
IEA
Genome Projectcellular response to prostaglandin E stimulus
GO:0071391
IDA
Genome Projectcellular response to estrogen stimulus
GO:0071392
IEP
Genome Projectcellular response to estradiol stimulus
GO:0071456
IEP
Genome Projectcellular response to hypoxia
GO:0071481
IEA
Genome Projectcellular response to X-ray
GO:0071504
IDA
Genome Projectcellular response to heparin
GO:0071560
IEP
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0071773
IEP
Genome Projectcellular response to BMP stimulus
GO:0090090
IDA, IMP
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090175
IEA
Genome Projectregulation of establishment of planar polarity
GO:0090179
IEA
Genome Projectplanar cell polarity pathway involved in neural tube closure
GO:0090244
IEA
Genome ProjectWnt signaling pathway involved in somitogenesis
GO:0090246
IEA
Genome Projectconvergent extension involved in somitogenesis
GO:0090263
IDA
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1902043
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041
IEA
Genome Projectnegative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052
IDA
Genome Projectpositive regulation of non-canonical Wnt signaling pathway
GO:2000054
IDA
Genome Projectnegative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000080
IDA
Genome Projectnegative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270
IDA
Genome Projectnegative regulation of fibroblast apoptotic process
GO:2000271
IDA
Genome Projectpositive regulation of fibroblast apoptotic process
GO:2001238
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004197
IMP
Genome Projectcysteine-type endopeptidase activity
GO:0005109
IPI
Genome Projectfrizzled binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008144
IDA
Genome Projectdrug binding
GO:0008201
IDA
Genome Projectheparin binding
GO:0017147
IPI
Genome ProjectWnt-protein binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0004930
IBA
Genome ProjectG-protein coupled receptor activity
GO:0042813
IBA
Genome ProjectWnt-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005578
IDA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IDA
Genome Projectextracellular space
GO:0005622
IDA
Genome Projectintracellular
GO:0005829
IDA
Genome Projectcytosol
GO:0005886
ISS
Genome Projectplasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0031012
IDA
Genome Projectextracellular matrix
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0016021
IBA
Genome Projectintegral component of membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001134Netrin domain
IPR008993Tissue inhibitor of metalloproteinases-like, OB-fold
IPR015526Frizzled/secreted frizzled-related protein
IPR018933Netrin module, non-TIMP type
IPR020067Frizzled domain
IPR026559Secreted frizzled-related protein 1

No MapMan annotations defined for this gene.