Gene: ENSG00000104312 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000104312
Transcript Identifier
ENST00000220751
Gene Type
Coding gene
Location
8 : 89758061-89790416 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P070279
(2 genes in 2 species)
specific family

Descriptions

gene_descr
receptor-interacting serine-threonine kinase 2

Identifiers

Type Value
pidENSP00000220751
HGNC10020
UniprotO43353

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0001961
IEA
Genome Projectpositive regulation of cytokine-mediated signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002250
ISS
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0002827
IEA
Genome Projectpositive regulation of T-helper 1 type immune response
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006954
TAS
Genome Projectinflammatory response
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007249
ISS
IEA
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007254
TAS
Genome ProjectJNK cascade
GO:0010800
IDA
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0031398
IMP
NAS
Genome Projectpositive regulation of protein ubiquitination
GO:0031663
IEA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032722
IEA
Genome Projectpositive regulation of chemokine production
GO:0032727
NAS
Genome Projectpositive regulation of interferon-alpha production
GO:0032728
NAS
Genome Projectpositive regulation of interferon-beta production
GO:0032729
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032735
NAS
Genome Projectpositive regulation of interleukin-12 production
GO:0032743
IEA
Genome Projectpositive regulation of interleukin-2 production
GO:0032755
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032760
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032874
IEA
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0033091
IEA
Genome Projectpositive regulation of immature T cell proliferation
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034134
IDA
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS, IEA
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042098
IEA
Genome ProjectT cell proliferation
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043123
IDA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330
IEA
Genome Projectresponse to exogenous dsRNA
GO:0045087
IDA
ISS
TAS, IEA
Genome Projectinnate immune response
GO:0045627
IEA
Genome Projectpositive regulation of T-helper 1 cell differentiation
GO:0045944
NAS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IEA
Genome Projectpositive regulation of JNK cascade
GO:0046641
IEA
Genome Projectpositive regulation of alpha-beta T cell proliferation
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050830
IEA
Genome Projectdefense response to Gram-positive bacterium
GO:0050852
ISS
TAS, IEA
Genome ProjectT cell receptor signaling pathway
GO:0051092
IMP
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070427
IEA
Genome Projectnucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431
IDA
Genome Projectnucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070555
IEA
Genome Projectresponse to interleukin-1
GO:0070671
IEA
Genome Projectresponse to interleukin-12
GO:0070673
IEA
Genome Projectresponse to interleukin-18
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071223
IEA
Genome Projectcellular response to lipoteichoic acid
GO:0071224
IEA
Genome Projectcellular response to peptidoglycan
GO:0071225
IDA
Genome Projectcellular response to muramyl dipeptide

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004715
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0004871
TAS
Genome Projectsignal transducer activity
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0030274
IPI
Genome ProjectLIM domain binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0050700
IDA, IPI
Genome ProjectCARD domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IDA
Genome Projectcytoskeleton
GO:0031982
IDA
Genome Projectvesicle
GO:0043234
IDA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001315CARD domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011029Death-like domain
IPR017322Receptor-interacting serine/threonine-protein kinase 2

No MapMan annotations defined for this gene.