Gene: ENSG00000103653 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000103653
Transcript Identifier
ENST00000567571
Gene Type
Coding gene
Location
15 : 74798298-74802513 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P027606
(4 genes in 4 species)
specific family

Descriptions

gene_descr
c-src tyrosine kinase

Identifiers

Type Value
pidENSP00000454906
HGNC2444
UniprotP41240
UniprotB2R6Q4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0007420
IEA
Genome Projectbrain development
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0010989
IEA
Genome Projectnegative regulation of low-density lipoprotein particle clearance
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0032715
IEA
Genome Projectnegative regulation of interleukin-6 production
GO:0033673
IEA
Genome Projectnegative regulation of kinase activity
GO:0034332
IBA
IEA
Genome Projectadherens junction organization
GO:0043406
IEA
Genome Projectpositive regulation of MAP kinase activity
GO:0045779
IEA
Genome Projectnegative regulation of bone resorption
GO:0046777
IEA
Genome Projectprotein autophosphorylation
GO:0048709
IEA
Genome Projectoligodendrocyte differentiation
GO:0050765
IEA
Genome Projectnegative regulation of phagocytosis
GO:0060368
IBA
IEA
Genome Projectregulation of Fc receptor mediated stimulatory signaling pathway
GO:0070373
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0071375
IEA
Genome Projectcellular response to peptide hormone stimulus
GO:0001817
IBA
Genome Projectregulation of cytokine production
GO:0002009
IBA
Genome Projectmorphogenesis of an epithelium
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007596
TAS
Genome Projectblood coagulation
GO:0016477
IBA
Genome Projectcell migration
GO:0030154
IBA
Genome Projectcell differentiation
GO:0030168
TAS
Genome Projectplatelet activation
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0042997
IDA
Genome Projectnegative regulation of Golgi to plasma membrane protein transport
GO:0045087
IBA
Genome Projectinnate immune response
GO:0050852
TAS
Genome ProjectT cell receptor signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019903
IEA
Genome Projectprotein phosphatase binding
GO:0070064
IEA
Genome Projectproline-rich region binding
GO:0005102
IBA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008022
TAS
Genome Projectprotein C-terminus binding
GO:0034236
IPI
Genome Projectprotein kinase A catalytic subunit binding
GO:0042802
IPI
Genome Projectidentical protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
TAS, IEA
Genome Projectcytoplasm
GO:0005911
IEA
Genome Projectcell-cell junction
GO:0045121
IEA
Genome Projectmembrane raft
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IPI
TAS, IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.