Gene: ENSG00000103490 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000103490
Transcript Identifier
ENST00000247470
Gene Type
Coding gene
Location
16 : 31201585-31202690 : negative

Family Information

Homologous gene family
HOM03P041300
(2 genes in 2 species)
specific family

Descriptions

gene_descr
PYD and CARD domain containing

Identifiers

Type Value
pidENSP00000247470
HGNC16608
UniprotQ9ULZ3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001773
IMP
Genome Projectmyeloid dendritic cell activation
GO:0002218
IDA
Genome Projectactivation of innate immune response
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002230
IEA
Genome Projectpositive regulation of defense response to virus by host
GO:0002277
ISS
IEA
Genome Projectmyeloid dendritic cell activation involved in immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002588
ISS
IEA
Genome Projectpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002821
IMP
Genome Projectpositive regulation of adaptive immune response
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006919
NAS, IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954
IEA
Genome Projectinflammatory response
GO:0007165
NAS
Genome Projectsignal transduction
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0010506
IEA
Genome Projectregulation of autophagy
GO:0010803
IMP
Genome Projectregulation of tumor necrosis factor-mediated signaling pathway
GO:0030838
ISS
IEA
Genome Projectpositive regulation of actin filament polymerization
GO:0031647
ISS
IEA
Genome Projectregulation of protein stability
GO:0032088
IMP
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032611
IEA
Genome Projectinterleukin-1 beta production
GO:0032688
IMP
Genome Projectnegative regulation of interferon-beta production
GO:0032729
ISS
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032755
ISS
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032760
IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0033209
IDA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042104
ISS
IEA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042771
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043087
IEA
Genome Projectregulation of GTPase activity
GO:0043124
IDA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281
IEA
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044351
ISS
IEA
Genome Projectmacropinocytosis
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0046330
IMP
Genome Projectpositive regulation of JNK cascade
GO:0050718
IDA
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050727
IEA
Genome Projectregulation of inflammatory response
GO:0050766
ISS
IEA
Genome Projectpositive regulation of phagocytosis
GO:0050829
IMP
Genome Projectdefense response to Gram-negative bacterium
GO:0050870
IMP
Genome Projectpositive regulation of T cell activation
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051607
IDA
Genome Projectdefense response to virus
GO:0070374
IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071347
IDA
Genome Projectcellular response to interleukin-1
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor
GO:0071901
IDA
Genome Projectnegative regulation of protein serine/threonine kinase activity
GO:0072332
IMP
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0090197
IMP
Genome Projectpositive regulation of chemokine secretion
GO:0090200
IDA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0097202
IEA
Genome Projectactivation of cysteine-type endopeptidase activity
GO:2000406
ISS
IEA
Genome Projectpositive regulation of T cell migration
GO:2000484
IMP
Genome Projectpositive regulation of interleukin-8 secretion
GO:2000778
IMP
Genome Projectpositive regulation of interleukin-6 secretion
GO:2001056
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity
GO:2001181
IMP
Genome Projectpositive regulation of interleukin-10 secretion
GO:2001238
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001242
IDA
Genome Projectregulation of intrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
Genome Projectprotease binding
GO:0005138
IPI
Genome Projectinterleukin-6 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005523
IPI
Genome Projecttropomyosin binding
GO:0008656
NAS
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0017024
IPI
Genome Projectmyosin I binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0032090
IPI
Genome ProjectPyrin domain binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0046983
IEA
Genome Projectprotein dimerization activity
GO:0070700
IPI
Genome ProjectBMP receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005634
IDA
ISS
IEA
Genome Projectnucleus
GO:0005730
IDA
Genome Projectnucleolus
GO:0005737
IDA
NAS, IEA
Genome Projectcytoplasm
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0008385
IDA
TAS
Genome ProjectIkappaB kinase complex
GO:0072558
IDA
Genome ProjectNLRP1 inflammasome complex
GO:0072559
IDA
Genome ProjectNLRP3 inflammasome complex
GO:0097169
IDA
Genome ProjectAIM2 inflammasome complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001315CARD domain
IPR004020DAPIN domain
IPR011029Death-like domain

No MapMan annotations defined for this gene.