Gene: ENSG00000102755 (Homo sapiens)

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Gene Identifier
ENSG00000102755
Transcript Identifier
ENST00000282397
Gene Type
Coding gene
Location
13 : 28303167-28494843 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P018477
(5 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
fms-related tyrosine kinase 1

Identifiers

Type Value
pidENSP00000282397
HGNC3763
UniprotP17948
UniprotL7RSL3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0038084
IDA, IMP
TAS, IEA
Genome Projectvascular endothelial growth factor signaling pathway
GO:0048010
IDA, IMP
TAS, IEA
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0001525
IEA
Genome Projectangiogenesis
GO:0002548
IDA
Genome Projectmonocyte chemotaxis
GO:0006935
IEA
Genome Projectchemotaxis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008284
TAS
Genome Projectpositive regulation of cell proliferation
GO:0010863
IMP
Genome Projectpositive regulation of phospholipase C activity
GO:0014068
IMP
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477
IMP
Genome Projectcell migration
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030335
IDA
Genome Projectpositive regulation of cell migration
GO:0030949
IDA
Genome Projectpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924
IDA
Genome Projectcellular response to vascular endothelial growth factor stimulus
GO:0036323
IDA
Genome Projectvascular endothelial growth factor receptor-1 signaling pathway
GO:0043406
IDA
Genome Projectpositive regulation of MAP kinase activity
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0043552
IMP
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0048514
ISS
Genome Projectblood vessel morphogenesis
GO:0048598
ISS
Genome Projectembryonic morphogenesis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005021
IDA, IMP
TAS, IEA
Genome Projectvascular endothelial growth factor-activated receptor activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019838
IPI
Genome Projectgrowth factor binding
GO:0036326
IDA
Genome ProjectVEGF-A-activated receptor activity
GO:0036327
IDA
Genome ProjectVEGF-B-activated receptor activity
GO:0036332
IDA
Genome Projectplacental growth factor-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005887
IDA
TAS, IEA
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
TAS
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005768
IEA
Genome Projectendosome
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0043235
IDA
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001824Tyrosine-protein kinase, receptor class III, conserved site
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR009135Vascular endothelial growth factor receptor 1 (VEGFR1)
IPR011009Protein kinase-like domain
IPR013098Immunoglobulin I-set
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.