Gene: ENSG00000102468 (Homo sapiens)

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Gene Identifier
ENSG00000102468
Transcript Identifier
ENST00000542664
Gene Type
Coding gene
Location
13 : 46834837-46895906 : negative

Family Information

Homologous gene family
HOM03P000241
(150 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P072076
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled

Identifiers

Type Value
pidENSP00000437737
HGNC5293
UniprotP28223

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001659
IEA
Genome Projecttemperature homeostasis
GO:0006874
IDA
Genome Projectcellular calcium ion homeostasis
GO:0006939
IEA
Genome Projectsmooth muscle contraction
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007202
IDA
Genome Projectactivation of phospholipase C activity
GO:0007204
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007208
IEA
Genome Projectphospholipase C-activating serotonin receptor signaling pathway
GO:0007210
IMP
TAS
Genome Projectserotonin receptor signaling pathway
GO:0007268
TAS
Genome Projectsynaptic transmission
GO:0007568
IEA
Genome Projectaging
GO:0007610
IEA
Genome Projectbehavior
GO:0007613
IEA
Genome Projectmemory
GO:0008219
IEA
Genome Projectcell death
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010513
IDA
Genome Projectpositive regulation of phosphatidylinositol biosynthetic process
GO:0014059
IEA
Genome Projectregulation of dopamine secretion
GO:0014065
IDA
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0014824
IEA
Genome Projectartery smooth muscle contraction
GO:0014832
IEA
Genome Projecturinary bladder smooth muscle contraction
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0030431
IEA
Genome Projectsleep
GO:0033674
IEA
Genome Projectpositive regulation of kinase activity
GO:0042493
IDA
IEA
Genome Projectresponse to drug
GO:0043267
IEA
Genome Projectnegative regulation of potassium ion transport
GO:0043406
IEA
Genome Projectpositive regulation of MAP kinase activity
GO:0044380
IEA
Genome Projectprotein localization to cytoskeleton
GO:0045600
IEA
Genome Projectpositive regulation of fat cell differentiation
GO:0045821
IEA
Genome Projectpositive regulation of glycolytic process
GO:0045907
IEA
Genome Projectpositive regulation of vasoconstriction
GO:0046883
IEA
Genome Projectregulation of hormone secretion
GO:0048148
IEA
Genome Projectbehavioral response to cocaine
GO:0050731
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050795
IEA
Genome Projectregulation of behavior
GO:0050965
IEA
Genome Projectdetection of temperature stimulus involved in sensory perception of pain
GO:0050966
IEA
Genome Projectdetection of mechanical stimulus involved in sensory perception of pain
GO:0051209
IDA, IMP
Genome Projectrelease of sequestered calcium ion into cytosol
GO:0051967
IEA
Genome Projectnegative regulation of synaptic transmission, glutamatergic
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001965
IEA
Genome ProjectG-protein alpha-subunit binding
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
IEA
Genome ProjectG-protein coupled receptor activity
GO:0004993
IDA
TAS, IEA
Genome Projectserotonin receptor activity
GO:0008144
IDA
Genome Projectdrug binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0051378
IDA
IEA
Genome Projectserotonin binding
GO:0071886
IDA
Genome Project1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
IEA
Genome Projectcytosol
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
TAS, IEA
Genome Projectintegral component of plasma membrane
GO:0005901
IEA
Genome Projectcaveola
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016023
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0030424
IEA
Genome Projectaxon
GO:0030425
IEA
Genome Projectdendrite
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0042995
IEA
Genome Projectcell projection
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0043198
IEA
Genome Projectdendritic shaft
GO:0070852
IEA
Genome Projectcell body fiber

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR0004555-Hydroxytryptamine 2A receptor
IPR0022315-hydroxytryptamine receptor family
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.